start (aa) | end (aa) | feature | details | |
25 | 645 | TOPO_DOM | Extracellular (Potential). | lost |
390 | 600 | REPEAT | Approximate. | lost |
515 | 519 | STRAND | | might get lost (downstream of altered splice site) |
520 | 522 | HELIX | | lost |
523 | 523 | DISULFID | | might get lost (downstream of altered splice site) |
523 | 526 | STRAND | | might get lost (downstream of altered splice site) |
526 | 526 | DISULFID | | might get lost (downstream of altered splice site) |
528 | 528 | CARBOHYD | N-linked (GlcNAc...). | might get lost (downstream of altered splice site) |
535 | 535 | DISULFID | | might get lost (downstream of altered splice site) |
535 | 537 | STRAND | | might get lost (downstream of altered splice site) |
539 | 539 | DISULFID | | might get lost (downstream of altered splice site) |
540 | 540 | CONFLICT | N -> K (in Ref. 1; CAA25240). | might get lost (downstream of altered splice site) |
541 | 546 | STRAND | | might get lost (downstream of altered splice site) |
548 | 551 | STRAND | | might get lost (downstream of altered splice site) |
554 | 557 | STRAND | | might get lost (downstream of altered splice site) |
555 | 555 | DISULFID | | might get lost (downstream of altered splice site) |
558 | 558 | DISULFID | | might get lost (downstream of altered splice site) |
562 | 562 | DISULFID | | might get lost (downstream of altered splice site) |
566 | 568 | STRAND | | might get lost (downstream of altered splice site) |
568 | 568 | CARBOHYD | N-linked (GlcNAc...); partial. | might get lost (downstream of altered splice site) |
570 | 575 | STRAND | | might get lost (downstream of altered splice site) |
571 | 571 | DISULFID | | might get lost (downstream of altered splice site) |
578 | 587 | STRAND | | might get lost (downstream of altered splice site) |
579 | 579 | DISULFID | | might get lost (downstream of altered splice site) |
582 | 582 | DISULFID | | might get lost (downstream of altered splice site) |
587 | 590 | MUTAGEN | DGPH->AGPA: Decreases intramolecular interactions and facilitates EGF binding. | might get lost (downstream of altered splice site) |
590 | 594 | STRAND | | might get lost (downstream of altered splice site) |
591 | 591 | DISULFID | | might get lost (downstream of altered splice site) |
595 | 595 | DISULFID | | might get lost (downstream of altered splice site) |
597 | 599 | STRAND | | might get lost (downstream of altered splice site) |
602 | 604 | HELIX | | might get lost (downstream of altered splice site) |
603 | 603 | CARBOHYD | N-linked (GlcNAc...); partial. | might get lost (downstream of altered splice site) |
607 | 611 | STRAND | | might get lost (downstream of altered splice site) |
609 | 609 | MUTAGEN | K->A: Decreases intramolecular interactions and facilitates EGF binding. | might get lost (downstream of altered splice site) |
615 | 619 | STRAND | | might get lost (downstream of altered splice site) |
617 | 617 | DISULFID | | might get lost (downstream of altered splice site) |
620 | 620 | DISULFID | | might get lost (downstream of altered splice site) |
624 | 624 | DISULFID | | might get lost (downstream of altered splice site) |
628 | 628 | DISULFID | | might get lost (downstream of altered splice site) |
629 | 632 | STRAND | | might get lost (downstream of altered splice site) |
633 | 635 | HELIX | | might get lost (downstream of altered splice site) |
636 | 636 | DISULFID | | might get lost (downstream of altered splice site) |
643 | 646 | STRAND | | might get lost (downstream of altered splice site) |
646 | 668 | TRANSMEM | Helical; (Potential). | might get lost (downstream of altered splice site) |
648 | 669 | HELIX | | might get lost (downstream of altered splice site) |
669 | 1210 | TOPO_DOM | Cytoplasmic (Potential). | might get lost (downstream of altered splice site) |
671 | 673 | STRAND | | might get lost (downstream of altered splice site) |
678 | 678 | MOD_RES | Phosphothreonine; by PKC and PKD/PRKD1. | might get lost (downstream of altered splice site) |
679 | 684 | HELIX | | might get lost (downstream of altered splice site) |
685 | 687 | HELIX | | might get lost (downstream of altered splice site) |
688 | 688 | MUTAGEN | L->A: Strongly reduced phosphorylation. | might get lost (downstream of altered splice site) |
688 | 692 | STRAND | | might get lost (downstream of altered splice site) |
688 | 704 | REGION | Important for dimerization, phosphorylation and activation. | might get lost (downstream of altered splice site) |
689 | 689 | MUTAGEN | V->A: Reduced autophosphorylation. | might get lost (downstream of altered splice site) |
689 | 689 | MUTAGEN | V->M: Constitutively activated kinase. | might get lost (downstream of altered splice site) |
690 | 690 | MUTAGEN | E->A: Reduced phosphorylation. | might get lost (downstream of altered splice site) |
692 | 692 | MUTAGEN | L->A,P: Strongly reduced phosphorylation. | might get lost (downstream of altered splice site) |
693 | 693 | MOD_RES | Phosphothreonine; by PKD/PRKD1. | might get lost (downstream of altered splice site) |
693 | 693 | MUTAGEN | T->D: Strongly reduced phosphorylation. | might get lost (downstream of altered splice site) |
693 | 693 | MUTAGEN | T->A: Increased phosphorylation. | might get lost (downstream of altered splice site) |
694 | 694 | MUTAGEN | P->A: Strongly reduced phosphorylation. | might get lost (downstream of altered splice site) |
694 | 697 | STRAND | | might get lost (downstream of altered splice site) |
695 | 695 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
699 | 699 | MUTAGEN | P->A: Reduced phosphorylation. | might get lost (downstream of altered splice site) |
700 | 700 | MUTAGEN | N->A: Abolishes phosphorylation. | might get lost (downstream of altered splice site) |
703 | 706 | STRAND | | might get lost (downstream of altered splice site) |
704 | 704 | MUTAGEN | L->A: Abolishes phosphorylation. | might get lost (downstream of altered splice site) |
705 | 705 | MUTAGEN | R->A: Abolishes phosphorylation. | might get lost (downstream of altered splice site) |
706 | 706 | MUTAGEN | I->A: Abolishes phosphorylation. | might get lost (downstream of altered splice site) |
709 | 711 | HELIX | | might get lost (downstream of altered splice site) |
712 | 721 | STRAND | | might get lost (downstream of altered splice site) |
712 | 979 | DOMAIN | Protein kinase. | might get lost (downstream of altered splice site) |
716 | 716 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). | might get lost (downstream of altered splice site) |
718 | 726 | NP_BIND | ATP. | might get lost (downstream of altered splice site) |
724 | 731 | STRAND | | might get lost (downstream of altered splice site) |
725 | 725 | MOD_RES | Phosphothreonine. | might get lost (downstream of altered splice site) |
734 | 736 | TURN | | might get lost (downstream of altered splice site) |
737 | 737 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). | might get lost (downstream of altered splice site) |
740 | 746 | STRAND | | might get lost (downstream of altered splice site) |
745 | 745 | MUTAGEN | K->A,M: Abolishes kinase activity. | might get lost (downstream of altered splice site) |
745 | 745 | BINDING | ATP. | might get lost (downstream of altered splice site) |
748 | 750 | STRAND | | might get lost (downstream of altered splice site) |
754 | 754 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). | might get lost (downstream of altered splice site) |
756 | 768 | HELIX | | might get lost (downstream of altered splice site) |
777 | 791 | STRAND | | might get lost (downstream of altered splice site) |
790 | 791 | NP_BIND | ATP. | might get lost (downstream of altered splice site) |
798 | 804 | HELIX | | might get lost (downstream of altered splice site) |
805 | 808 | TURN | | might get lost (downstream of altered splice site) |
811 | 830 | HELIX | | might get lost (downstream of altered splice site) |
837 | 837 | ACT_SITE | Proton acceptor (By similarity). | might get lost (downstream of altered splice site) |
840 | 842 | HELIX | | might get lost (downstream of altered splice site) |
843 | 847 | STRAND | | might get lost (downstream of altered splice site) |
850 | 853 | STRAND | | might get lost (downstream of altered splice site) |
855 | 855 | BINDING | ATP. | might get lost (downstream of altered splice site) |
858 | 862 | HELIX | | might get lost (downstream of altered splice site) |
863 | 865 | TURN | | might get lost (downstream of altered splice site) |
867 | 867 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). | might get lost (downstream of altered splice site) |
868 | 870 | STRAND | | might get lost (downstream of altered splice site) |
869 | 869 | MOD_RES | Phosphotyrosine. | might get lost (downstream of altered splice site) |
878 | 880 | HELIX | | might get lost (downstream of altered splice site) |
883 | 888 | HELIX | | might get lost (downstream of altered splice site) |
893 | 908 | HELIX | | might get lost (downstream of altered splice site) |
909 | 911 | TURN | | might get lost (downstream of altered splice site) |
914 | 917 | TURN | | might get lost (downstream of altered splice site) |
920 | 922 | HELIX | | might get lost (downstream of altered splice site) |
923 | 928 | HELIX | | might get lost (downstream of altered splice site) |
929 | 929 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). | might get lost (downstream of altered splice site) |
937 | 939 | STRAND | | might get lost (downstream of altered splice site) |
941 | 950 | HELIX | | might get lost (downstream of altered splice site) |
955 | 957 | HELIX | | might get lost (downstream of altered splice site) |
961 | 972 | HELIX | | might get lost (downstream of altered splice site) |
970 | 970 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). | might get lost (downstream of altered splice site) |
974 | 974 | MUTAGEN | D->A: Strongly reduced phosphorylation. | might get lost (downstream of altered splice site) |
975 | 978 | HELIX | | might get lost (downstream of altered splice site) |
977 | 977 | MUTAGEN | R->A: Reduced phosphorylation. | might get lost (downstream of altered splice site) |
978 | 978 | MOD_RES | Phosphotyrosine. | might get lost (downstream of altered splice site) |
984 | 986 | HELIX | | might get lost (downstream of altered splice site) |
991 | 991 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
992 | 994 | TURN | | might get lost (downstream of altered splice site) |
993 | 993 | MOD_RES | Phosphothreonine. | might get lost (downstream of altered splice site) |
995 | 995 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
996 | 1002 | HELIX | | might get lost (downstream of altered splice site) |
998 | 998 | MOD_RES | Phosphotyrosine; by autocatalysis. | might get lost (downstream of altered splice site) |
1004 | 1006 | TURN | | might get lost (downstream of altered splice site) |
1005 | 1006 | MUTAGEN | ED->RK: Constitutively activated kinase. | might get lost (downstream of altered splice site) |
1007 | 1009 | HELIX | | might get lost (downstream of altered splice site) |
1013 | 1016 | HELIX | | might get lost (downstream of altered splice site) |
1016 | 1016 | MOD_RES | Phosphotyrosine; by autocatalysis. | might get lost (downstream of altered splice site) |
1016 | 1016 | MUTAGEN | Y->F: 50% decrease in interaction with PIK3C2B. 65% decrease in interaction with PIK3C2B; when associated with F-1197. Abolishes interaction with PIK3C2B; when associated with F-1197 and F-1092. | might get lost (downstream of altered splice site) |
1016 | 1016 | SITE | Important for interaction with PIK3C2B. | might get lost (downstream of altered splice site) |
1025 | 1025 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1025 | 1071 | COMPBIAS | Ser-rich. | might get lost (downstream of altered splice site) |
1026 | 1026 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1037 | 1037 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1039 | 1039 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1041 | 1041 | MOD_RES | Phosphothreonine. | might get lost (downstream of altered splice site) |
1042 | 1042 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1045 | 1045 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1064 | 1064 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1068 | 1070 | STRAND | | might get lost (downstream of altered splice site) |
1069 | 1069 | MOD_RES | Phosphotyrosine. | might get lost (downstream of altered splice site) |
1070 | 1070 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1071 | 1071 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1081 | 1081 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1092 | 1092 | MOD_RES | Phosphotyrosine; by autocatalysis. | might get lost (downstream of altered splice site) |
1092 | 1092 | MUTAGEN | Y->F: No change in interaction with PIK3C2B. Abolishes interaction with PIK3C2B; when associated with F-1197 and F-1016. | might get lost (downstream of altered splice site) |
1110 | 1110 | MUTAGEN | Y->F: No change in interaction with PIK3C2B. | might get lost (downstream of altered splice site) |
1110 | 1110 | MOD_RES | Phosphotyrosine; by autocatalysis. | might get lost (downstream of altered splice site) |
1138 | 1138 | MOD_RES | Phosphotyrosine. | might get lost (downstream of altered splice site) |
1166 | 1166 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
1172 | 1172 | MOD_RES | Phosphotyrosine; by autocatalysis. | might get lost (downstream of altered splice site) |
1172 | 1172 | MUTAGEN | Y->F: No change in interaction with PIK3C2B. | might get lost (downstream of altered splice site) |
1197 | 1197 | MUTAGEN | Y->F: No change in interaction with PIK3C2B. 65% decrease in interaction with PIK3C2B; when associated with F-1016. Abolishes interaction with PIK3C2B; when associated with F-1092 and F-1016. | might get lost (downstream of altered splice site) |
1197 | 1197 | MOD_RES | Phosphotyrosine; by autocatalysis. | might get lost (downstream of altered splice site) |
1199 | 1199 | MOD_RES | Omega-N-methylated arginine. | might get lost (downstream of altered splice site) |