start (aa) | end (aa) | feature | details | |
1 | 83 | REGION | Interaction with HRMT1L2. | lost |
66 | 110 | REGION | Interaction with WWOX. | lost |
99 | 99 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
100 | 370 | REGION | Interaction with HIPK1 (By similarity). | might get lost (downstream of altered splice site) |
102 | 292 | DNA_BIND | | might get lost (downstream of altered splice site) |
105 | 108 | TURN | | might get lost (downstream of altered splice site) |
110 | 112 | STRAND | | might get lost (downstream of altered splice site) |
113 | 236 | REGION | Required for interaction with FBXO42. | might get lost (downstream of altered splice site) |
116 | 292 | REGION | Interaction with AXIN1 (By similarity). | might get lost (downstream of altered splice site) |
118 | 120 | STRAND | | might get lost (downstream of altered splice site) |
120 | 120 | SITE | Interaction with DNA. | might get lost (downstream of altered splice site) |
121 | 123 | TURN | | might get lost (downstream of altered splice site) |
124 | 127 | STRAND | | might get lost (downstream of altered splice site) |
128 | 131 | TURN | | might get lost (downstream of altered splice site) |
132 | 135 | STRAND | | might get lost (downstream of altered splice site) |
141 | 146 | STRAND | | might get lost (downstream of altered splice site) |
156 | 165 | STRAND | | might get lost (downstream of altered splice site) |
166 | 168 | HELIX | | might get lost (downstream of altered splice site) |
176 | 176 | METAL | Zinc. | might get lost (downstream of altered splice site) |
177 | 180 | HELIX | | might get lost (downstream of altered splice site) |
179 | 179 | METAL | Zinc. | might get lost (downstream of altered splice site) |
181 | 183 | STRAND | | might get lost (downstream of altered splice site) |
183 | 183 | MUTAGEN | S->A: Abolishes strongly phosphorylation. | might get lost (downstream of altered splice site) |
183 | 183 | MOD_RES | Phosphoserine; by AURKB. | might get lost (downstream of altered splice site) |
183 | 183 | MUTAGEN | S->E: Inhibits slightly its transcriptional activity. | might get lost (downstream of altered splice site) |
187 | 189 | STRAND | | might get lost (downstream of altered splice site) |
194 | 199 | STRAND | | might get lost (downstream of altered splice site) |
204 | 207 | STRAND | | might get lost (downstream of altered splice site) |
209 | 211 | TURN | | might get lost (downstream of altered splice site) |
214 | 219 | STRAND | | might get lost (downstream of altered splice site) |
225 | 227 | TURN | | might get lost (downstream of altered splice site) |
228 | 236 | STRAND | | might get lost (downstream of altered splice site) |
238 | 238 | METAL | Zinc. | might get lost (downstream of altered splice site) |
240 | 242 | HELIX | | might get lost (downstream of altered splice site) |
241 | 248 | REGION | Interacts with the 53BP2 SH3 domain. | might get lost (downstream of altered splice site) |
242 | 242 | METAL | Zinc. | might get lost (downstream of altered splice site) |
243 | 248 | TURN | | might get lost (downstream of altered splice site) |
251 | 258 | STRAND | | might get lost (downstream of altered splice site) |
256 | 294 | REGION | Interaction with E4F1. | might get lost (downstream of altered splice site) |
260 | 262 | STRAND | | might get lost (downstream of altered splice site) |
264 | 274 | STRAND | | might get lost (downstream of altered splice site) |
269 | 269 | MOD_RES | Phosphoserine; by AURKB. | might get lost (downstream of altered splice site) |
269 | 269 | MUTAGEN | S->A: Abolishes strongly phosphorylation. | might get lost (downstream of altered splice site) |
269 | 269 | MUTAGEN | S->E: Inhibits strongly its transcriptional activity. | might get lost (downstream of altered splice site) |
273 | 280 | REGION | Interaction with DNA. | might get lost (downstream of altered splice site) |
278 | 287 | HELIX | | might get lost (downstream of altered splice site) |
284 | 284 | MOD_RES | Phosphothreonine; by AURKB. | might get lost (downstream of altered splice site) |
284 | 284 | MUTAGEN | T->E: Inhibits strongly its transcriptional activity. | might get lost (downstream of altered splice site) |
288 | 290 | HELIX | | might get lost (downstream of altered splice site) |
291 | 291 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). | might get lost (downstream of altered splice site) |
291 | 292 | MUTAGEN | KK->RR: Abolishes polyubiquitination by MKRN1. | might get lost (downstream of altered splice site) |
292 | 292 | MOD_RES | N6-acetyllysine. | might get lost (downstream of altered splice site) |
292 | 292 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). | might get lost (downstream of altered splice site) |
300 | 393 | REGION | Interaction with CARM1. | might get lost (downstream of altered splice site) |
305 | 305 | MOD_RES | N6-acetyllysine. | might get lost (downstream of altered splice site) |
305 | 321 | MOTIF | Bipartite nuclear localization signal. | might get lost (downstream of altered splice site) |
313 | 313 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
314 | 314 | MOD_RES | Phosphoserine. | might get lost (downstream of altered splice site) |
315 | 315 | MOD_RES | Phosphoserine; by AURKA, CDK1 and CDK2. | might get lost (downstream of altered splice site) |
319 | 319 | MUTAGEN | K->A: Loss of nuclear localization; when associated with A-320 and A-321. | might get lost (downstream of altered splice site) |
319 | 360 | REGION | Interaction with HIPK2. | might get lost (downstream of altered splice site) |
320 | 320 | MUTAGEN | K->A: Loss of nuclear localization; when associated with A-319 and A-321. | might get lost (downstream of altered splice site) |
321 | 321 | MUTAGEN | K->A: Loss of nuclear localization; when associated with A-319 and A-320. | might get lost (downstream of altered splice site) |
321 | 324 | HELIX | | might get lost (downstream of altered splice site) |
325 | 356 | REGION | Oligomerization. | might get lost (downstream of altered splice site) |
327 | 334 | STRAND | | might get lost (downstream of altered splice site) |
335 | 354 | HELIX | | might get lost (downstream of altered splice site) |
339 | 350 | MOTIF | Nuclear export signal. | might get lost (downstream of altered splice site) |
359 | 359 | MUTAGEN | P->D: Abolishes binding to USP7. | might get lost (downstream of altered splice site) |
359 | 363 | REGION | Interaction with USP7. | might get lost (downstream of altered splice site) |
361 | 361 | MUTAGEN | G->E: Abolishes binding to USP7. | might get lost (downstream of altered splice site) |
362 | 362 | MUTAGEN | S->A: Abolishes binding to USP7. | might get lost (downstream of altered splice site) |
368 | 387 | REGION | Basic (repression of DNA-binding). | might get lost (downstream of altered splice site) |
370 | 370 | MOD_RES | N6-methyllysine; by SMYD2; alternate. | might get lost (downstream of altered splice site) |
370 | 370 | MUTAGEN | K->R: Induces a decrease in methylation by SMYD2. | might get lost (downstream of altered splice site) |
370 | 370 | MOD_RES | N6,N6-dimethyllysine; alternate. | might get lost (downstream of altered splice site) |
370 | 372 | MOTIF | [KR]-[STA]-K motif. | might get lost (downstream of altered splice site) |
372 | 372 | MOD_RES | N6-methyllysine; by SETD7. | might get lost (downstream of altered splice site) |
372 | 372 | MUTAGEN | K->R: Induces a decrease in protein stabilization. | might get lost (downstream of altered splice site) |
373 | 373 | MOD_RES | N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate. | might get lost (downstream of altered splice site) |
373 | 373 | MUTAGEN | K->R: Abolishes dimethylation by EHMT1 and EHMT2. | might get lost (downstream of altered splice site) |
373 | 373 | MOD_RES | N6-acetyllysine; alternate. | might get lost (downstream of altered splice site) |
375 | 380 | HELIX | | might get lost (downstream of altered splice site) |
381 | 381 | MOD_RES | N6-acetyllysine. | might get lost (downstream of altered splice site) |
382 | 382 | MUTAGEN | K->R: Abolishes monomethylation by SETD8. | might get lost (downstream of altered splice site) |
382 | 382 | MUTAGEN | K->A: Abolishes acetylation by CREBBP. | might get lost (downstream of altered splice site) |
382 | 382 | MOD_RES | N6-acetyllysine; alternate. | might get lost (downstream of altered splice site) |
382 | 382 | MOD_RES | N6-methyllysine; by SETD8; alternate. | might get lost (downstream of altered splice site) |
382 | 385 | TURN | | might get lost (downstream of altered splice site) |
383 | 383 | MUTAGEN | L->A: Abolishes S-315 phosphorylation by CDK2/cyclin A. | might get lost (downstream of altered splice site) |
385 | 385 | MUTAGEN | F->A: Reduced SUMO1 conjugation. | might get lost (downstream of altered splice site) |
386 | 386 | CROSSLNK | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO). | might get lost (downstream of altered splice site) |
386 | 386 | MUTAGEN | K->A: Abolishes SUMO1 conjugation, in vitro and in vivo. | might get lost (downstream of altered splice site) |
387 | 387 | MUTAGEN | T->A: No effect SUMO1 conjugation. | might get lost (downstream of altered splice site) |
388 | 388 | MUTAGEN | E->A: Abolishes SUMO1 conjugation. | might get lost (downstream of altered splice site) |
392 | 392 | MOD_RES | Phosphoserine; by CK2, CDK2 and NUAK1. | might get lost (downstream of altered splice site) |