start (aa) | end (aa) | feature | details | |
1 | 1 | INIT_MET | Removed. | might get lost (downstream of altered splice site) |
2 | 33 | REGION | Necessary for interaction with YBX1, binding to RNA, NPM1-dependent association with rRNA, endoribonuclease activity on abasic RNA and localization in the nucleoli. | might get lost (downstream of altered splice site) |
6 | 6 | MUTAGEN | K->R: Lack of acetylation, does not stimulate the YBX1-mediated MDR1 promoter activity and alter nuclear subcellular localization; when associated with R-7. Does not inhibit interaction with HDAC1, HDAC2 and HDAC3. Absence of increase in nCaRE binding activity. | might get lost (downstream of altered splice site) |
6 | 6 | MOD_RES | N6-acetyllysine; by EP300. | might get lost (downstream of altered splice site) |
7 | 7 | MOD_RES | N6-acetyllysine; by EP300. | might get lost (downstream of altered splice site) |
7 | 7 | MUTAGEN | K->R: Lack of acetylation and does not stimulate the YBX1-mediated MDR1 promoter activity and alter nuclear subcellular localization; when associated with R-6. | might get lost (downstream of altered splice site) |
8 | 13 | REGION | Nuclear localization signal (NLS). | might get lost (downstream of altered splice site) |
12 | 12 | MUTAGEN | E->A: Reduces nuclear localization; when associated with A-13. | might get lost (downstream of altered splice site) |
13 | 13 | MUTAGEN | D->A: Reduces nuclear localization; when associated with A-12. | might get lost (downstream of altered splice site) |
23 | 33 | REGION | Necessary for interaction with NPM1 and for efficient rRNA binding. | might get lost (downstream of altered splice site) |
24 | 24 | MUTAGEN | K->A: Enhances the interaction with TOMM20. Inhibits rRNA binding, interaction with NPM1, nuclear localization and modulates its endodeoxyribonuclease activity; when associated with A-25; A-27; A-31 and A- 32. Inhibits ubiquitination; when associated with K-25 and K-27. | might get lost (downstream of altered splice site) |
25 | 25 | MUTAGEN | K->A: Enhances the interaction with TOMM20. Inhibits rRNA binding, interaction with NPM1, nuclear localization and modulates its endodeoxyribonuclease activity; when associated with A-24; A-27; A-31 and A- 32. Inhibits ubiquitination; when associated with K-24 and K-27. | might get lost (downstream of altered splice site) |
27 | 27 | MUTAGEN | K->A: Enhances the interaction with TOMM20. Inhibits rRNA binding, interaction with NPM1, nuclear localization and modulates its endodeoyribonuclease activity; when associated with A-24; A-25; A-31 and A- 32. Inhibits ubiquitination; when associated with K-24 and K-25. | might get lost (downstream of altered splice site) |
27 | 27 | MOD_RES | N6-acetyllysine. | might get lost (downstream of altered splice site) |
31 | 31 | MUTAGEN | K->A: Enhances the interaction with TOMM20. Does not inhibit redox and AP endodeoyribonuclease activities. Inhibits rRNA binding, interaction with NPM1, nuclear localization and modulates its endodeoxyribonuclease activity; when associated with A-24; A-25; A-27 and A- 32. Reduces protection from granzyme A- mediated cell death; when associated with A-65 and A-210. | might get lost (downstream of altered splice site) |
31 | 31 | MOD_RES | N6-acetyllysine. | might get lost (downstream of altered splice site) |
31 | 32 | SITE | Cleavage; by granzyme A. | might get lost (downstream of altered splice site) |
32 | 32 | MUTAGEN | K->A: Inhibits rRNA binding, interaction with NPM1, nuclear localization and modulates its endodeoxyribonuclease activity; when associated with A-24; A- 25; A-27 and A-31. | might get lost (downstream of altered splice site) |
32 | 32 | MOD_RES | N6-acetyllysine. | might get lost (downstream of altered splice site) |
35 | 35 | MOD_RES | N6-acetyllysine. | might get lost (downstream of altered splice site) |
57 | 57 | CONFLICT | G -> A (in Ref. 2; AAA58371). | might get lost (downstream of altered splice site) |
62 | 68 | STRAND | | might get lost (downstream of altered splice site) |
64 | 80 | REGION | Nuclear export signal (NES). | might get lost (downstream of altered splice site) |
65 | 65 | DISULFID | Probable. | might get lost (downstream of altered splice site) |
65 | 65 | MOD_RES | S-nitrosocysteine. | might get lost (downstream of altered splice site) |
65 | 65 | MUTAGEN | C->A: Abolishes the redox activity. Does not abolish the AP endodeoxyribonuclease and phosphodiesterase activities. Reduces protection from granzyme A-mediated cell death; when associated with A-31 and A- 210. | might get lost (downstream of altered splice site) |
65 | 65 | MUTAGEN | C->S: Does not abolish NO-induced nitrosylation. Enhances NO-induced nuclear export. | might get lost (downstream of altered splice site) |
68 | 68 | METAL | Magnesium or manganese. | might get lost (downstream of altered splice site) |
72 | 77 | HELIX | | might get lost (downstream of altered splice site) |
80 | 87 | HELIX | | might get lost (downstream of altered splice site) |
90 | 95 | STRAND | | might get lost (downstream of altered splice site) |
93 | 93 | MUTAGEN | C->S: Does not abolish NO-induced nitrosylation. Abolishes NO-induced nitrosylation and translocation from the nucleus to the cytoplasm; when associated with S-310. | might get lost (downstream of altered splice site) |
93 | 93 | DISULFID | Probable. | might get lost (downstream of altered splice site) |
93 | 93 | MUTAGEN | C->A: Abolishes partially the redox activity. | might get lost (downstream of altered splice site) |
93 | 93 | MOD_RES | S-nitrosocysteine. | might get lost (downstream of altered splice site) |
96 | 96 | MUTAGEN | E->A: Lacks MYC CRD RNA cleavage activity. | might get lost (downstream of altered splice site) |
96 | 96 | METAL | Magnesium or manganese. | might get lost (downstream of altered splice site) |
99 | 99 | MUTAGEN | C->A: Does not abolish the redox activity. | might get lost (downstream of altered splice site) |
101 | 103 | HELIX | | might get lost (downstream of altered splice site) |
106 | 110 | HELIX | | might get lost (downstream of altered splice site) |
112 | 114 | HELIX | | might get lost (downstream of altered splice site) |
116 | 120 | STRAND | | might get lost (downstream of altered splice site) |
122 | 124 | STRAND | | might get lost (downstream of altered splice site) |
126 | 128 | STRAND | | might get lost (downstream of altered splice site) |
131 | 137 | STRAND | | might get lost (downstream of altered splice site) |
138 | 138 | MUTAGEN | C->A: Does not abolish the redox activity. | might get lost (downstream of altered splice site) |
140 | 145 | STRAND | | might get lost (downstream of altered splice site) |
149 | 151 | HELIX | | might get lost (downstream of altered splice site) |
152 | 154 | STRAND | | might get lost (downstream of altered splice site) |
157 | 161 | STRAND | | might get lost (downstream of altered splice site) |
166 | 171 | STRAND | | might get lost (downstream of altered splice site) |
177 | 179 | HELIX | | might get lost (downstream of altered splice site) |
182 | 200 | HELIX | | might get lost (downstream of altered splice site) |
197 | 197 | MOD_RES | N6-acetyllysine. | might get lost (downstream of altered splice site) |
205 | 210 | STRAND | | might get lost (downstream of altered splice site) |
208 | 208 | MUTAGEN | C->A: Does not abolish the redox activity. | might get lost (downstream of altered splice site) |
210 | 210 | MUTAGEN | D->A: Abolishes the AP endodeoxyribonuclease activity. Reduces protection from granzyme A-mediated cell death; when associated with A-31 and A- 65. | might get lost (downstream of altered splice site) |
210 | 210 | METAL | Magnesium or manganese. | might get lost (downstream of altered splice site) |
212 | 212 | METAL | Magnesium or manganese. | might get lost (downstream of altered splice site) |
212 | 212 | MUTAGEN | N->A: Abolishes AP endodeoxyribonuclease activity. | might get lost (downstream of altered splice site) |
212 | 212 | MUTAGEN | N->Q,D: Decreases AP endodeoxyribonuclease activity. | might get lost (downstream of altered splice site) |
217 | 219 | HELIX | | might get lost (downstream of altered splice site) |
223 | 225 | TURN | | might get lost (downstream of altered splice site) |
227 | 229 | STRAND | | might get lost (downstream of altered splice site) |
230 | 232 | TURN | | might get lost (downstream of altered splice site) |
233 | 233 | MOD_RES | Phosphothreonine; by CDK5 (By similarity). | might get lost (downstream of altered splice site) |
234 | 246 | HELIX | | might get lost (downstream of altered splice site) |
249 | 251 | STRAND | | might get lost (downstream of altered splice site) |
252 | 256 | HELIX | | might get lost (downstream of altered splice site) |
257 | 259 | STRAND | | might get lost (downstream of altered splice site) |
262 | 262 | MOD_RES | Phosphotyrosine. | might get lost (downstream of altered splice site) |
270 | 272 | HELIX | | might get lost (downstream of altered splice site) |
273 | 276 | HELIX | | might get lost (downstream of altered splice site) |
283 | 287 | STRAND | | might get lost (downstream of altered splice site) |
289 | 294 | HELIX | | might get lost (downstream of altered splice site) |
289 | 318 | REGION | Mitochondrial targeting sequence (MTS). | might get lost (downstream of altered splice site) |
295 | 300 | STRAND | | might get lost (downstream of altered splice site) |
296 | 296 | MUTAGEN | C->A: Does not abolish the redox activity. | might get lost (downstream of altered splice site) |
299 | 299 | MUTAGEN | K->A: Reduces the interaction with TOMM20. Abolishes localization in the mitochondria; when associated with A-301. | might get lost (downstream of altered splice site) |
301 | 301 | MUTAGEN | R->A: Reduces the interaction with TOMM20. Abolishes localization in the mitochondria; when associated with A-299. | might get lost (downstream of altered splice site) |
303 | 303 | MUTAGEN | K->A: Reduces the interaction with TOMM20. | might get lost (downstream of altered splice site) |
306 | 306 | CONFLICT | G -> A (in Ref. 2; AAA58371). | might get lost (downstream of altered splice site) |
306 | 309 | STRAND | | might get lost (downstream of altered splice site) |
308 | 308 | METAL | Magnesium or manganese. | might get lost (downstream of altered splice site) |
309 | 309 | ACT_SITE | Proton acceptor (By similarity). | might get lost (downstream of altered splice site) |
309 | 309 | MUTAGEN | H->N: Lacks MYC CRD RNA cleavage activity. | might get lost (downstream of altered splice site) |
309 | 309 | METAL | Magnesium or manganese. | might get lost (downstream of altered splice site) |
310 | 310 | MOD_RES | S-nitrosocysteine. | might get lost (downstream of altered splice site) |
310 | 310 | MUTAGEN | C->A: Does not abolish the redox activity. | might get lost (downstream of altered splice site) |
310 | 310 | MUTAGEN | C->S: Does not abolish NO-induced nitrosylation. Abolishes NO-induced nitrosylation and translocation from the nucleus to the cytoplasm; when associated with S-93. | might get lost (downstream of altered splice site) |
312 | 316 | STRAND | | might get lost (downstream of altered splice site) |