MutationTaster - study a chromosomal position

NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 4 transcript(s)...
Querying Taster for transcript #1: ENST00000344255
Querying Taster for transcript #2: ENST00000320185
Querying Taster for transcript #3: ENST00000346714
Querying Taster for transcript #4: ENST00000347978
MT speed 0 s - this script 4.050668 s

Results

genesymbol	prediction	probability	model	prediction problem	splicing	ClinVar	amino acid changes	variant type	dbSNP ID	protein length	file
FGF8	disease_causing_automatic	0.999987481543207	simple_aae		affected	0	K89E	single base exchange	rs137852662		show file
FGF8	disease_causing_automatic	0.999987481543207	simple_aae		affected	0	K60E	single base exchange	rs137852662		show file
FGF8	disease_causing_automatic	0.999997235956533	simple_aae		affected	0	K71E	single base exchange	rs137852662		show file
FGF8	disease_causing_automatic	0.999997945921173	simple_aae		affected	0	K100E	single base exchange	rs137852662		show file

Taster files

mutation t@sting

documentation

Prediction

disease causing

Model: simple_aae, prob: 0.999987481543207 (classification due to ClinVar, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
known disease mutation at this position (HGMD CM082675)
known disease mutation: rs9124 (pathogenic)
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr10:103534528T>CN/A show variant in all transcripts IGV

HGNC symbol

FGF8

Ensembl transcript ID

ENST00000344255

Genbank transcript ID

NM_033164

UniProt peptide

P55075

alteration type

single base exchange

alteration region

CDS

DNA changes

c.265A>G
cDNA.265A>G
g.1300A>G

AA changes

K89E Score: 56 explain score(s)

position(s) of altered AA
if AA alteration in CDS

frameshift

known variant

Reference ID: rs137852662
Allele 'C' was neither found in ExAC nor 1000G.
known disease mutation: rs9124 (pathogenic for Hypogonadotropic hypogonadism 6 with or without anosmia) dbSNP NCBI variation viewer
known disease mutation at this position, please check HGMD for details (HGMD ID CM082675)

known disease mutation at this position, please check HGMD for details (HGMD ID CM082675)
known disease mutation at this position, please check HGMD for details (HGMD ID CM082675)

regulatory features

CTCF, Transcription Factor, CCCTC-binding factor
DNase1, Open Chromatin, DNase1 Hypersensitive Site
H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
H3K4me2, Histone, Histone 3 Lysine 4 Di-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	3.073	1
	4.677	1
(flanking)	5.662	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	1293	wt: 0.9010 / mu: 0.9127 (marginal change - not scored)	wt: GTCCTGGCCAACAAG mu: GTCCTGGCCAACGAG	CCTG\|gcca
Donor gained	1294	0.44	mu: TCCTGGCCAACGAGC	CTGG\|ccaa

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

mutated

all conserved

Ptroglodytes

all identical

ENSPTRG00000002874

Mmulatta

no alignment

ENSMMUG00000015771

n/a

Fcatus

not conserved

ENSFCAG00000007177

Mmusculus

all identical

ENSMUSG00000025219

124

Ggallus

all identical

ENSGALG00000007706

Trubripes

no homologue

Drerio

all identical

ENSDARG00000003399

Dmelanogaster

not conserved

FBgn0014135

268

Celegans

no alignment

C05D11.4

n/a

Xtropicalis

all identical

ENSXETG00000014474

100

protein features

start (aa)	end (aa)	feature	details
91	95	STRAND		might get lost (downstream of altered splice site)
100	102	HELIX		might get lost (downstream of altered splice site)
104	110	STRAND		might get lost (downstream of altered splice site)
111	113	TURN		might get lost (downstream of altered splice site)
114	119	STRAND		might get lost (downstream of altered splice site)
120	122	TURN		might get lost (downstream of altered splice site)
125	128	STRAND		might get lost (downstream of altered splice site)
134	138	STRAND		might get lost (downstream of altered splice site)
143	145	HELIX		might get lost (downstream of altered splice site)
146	151	STRAND		might get lost (downstream of altered splice site)
155	155	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
157	164	STRAND		might get lost (downstream of altered splice site)
180	182	HELIX		might get lost (downstream of altered splice site)
188	190	HELIX		might get lost (downstream of altered splice site)
192	195	STRAND		might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

702 / 702

position (AA) of stopcodon in wt / mu AA sequence

234 / 234

position of stopcodon in wt / mu cDNA

702 / 702

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

1 / 1

chromosome

strand

-1

last intron/exon boundary

412

theoretical NMD boundary in CDS

361

length of CDS

702

coding sequence (CDS) position

265

cDNA position
(for ins/del: last normal base / first normal base)

265

gDNA position
(for ins/del: last normal base / first normal base)

1300

chromosomal position
(for ins/del: last normal base / first normal base)

103534528

original gDNA sequence snippet

ACGTGCAGGTCCTGGCCAACAAGCGCATCAACGCCATGGCA

altered gDNA sequence snippet

ACGTGCAGGTCCTGGCCAACGAGCGCATCAACGCCATGGCA

original cDNA sequence snippet

ACGTGCAGGTCCTGGCCAACAAGCGCATCAACGCCATGGCA

altered cDNA sequence snippet

ACGTGCAGGTCCTGGCCAACGAGCGCATCAACGCCATGGCA

wildtype AA sequence

MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV
TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA
ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG
SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR*

mutated AA sequence

MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV
TDQLSRRLIR TYQLYSRTSG KHVQVLANER INAMAEDGDP FAKLIVETDT FGSRVRVRGA
ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG
SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR*

speed

0.30 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

mutation t@sting

documentation

Prediction

disease causing

Model: simple_aae, prob: 0.999987481543207 (classification due to ClinVar, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
known disease mutation at this position (HGMD CM082675)
known disease mutation: rs9124 (pathogenic)
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr10:103534528T>CN/A show variant in all transcripts IGV

HGNC symbol

FGF8

Ensembl transcript ID

ENST00000346714

Genbank transcript ID

NM_033165

UniProt peptide

P55075

alteration type

single base exchange

alteration region

CDS

DNA changes

c.178A>G
cDNA.252A>G
g.1300A>G

AA changes

K60E Score: 56 explain score(s)

position(s) of altered AA
if AA alteration in CDS

frameshift

known variant

regulatory features

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	3.073	1
	4.677	1
(flanking)	5.662	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	1293	wt: 0.9010 / mu: 0.9127 (marginal change - not scored)	wt: GTCCTGGCCAACAAG mu: GTCCTGGCCAACGAG	CCTG\|gcca
Donor gained	1294	0.44	mu: TCCTGGCCAACGAGC	CTGG\|ccaa

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

mutated

all conserved

Ptroglodytes

all identical

ENSPTRG00000002874

Mmulatta

no alignment

ENSMMUG00000015771

n/a

Fcatus

not conserved

ENSFCAG00000007177

Mmusculus

all identical

ENSMUSG00000025219

124

Ggallus

all identical

ENSGALG00000007706

Trubripes

no homologue

Drerio

all identical

ENSDARG00000003399

Dmelanogaster

not conserved

FBgn0014135

268

Celegans

no alignment

C05D11.4

n/a

Xtropicalis

all identical

ENSXETG00000014474

100

protein features

start (aa)	end (aa)	feature	details
63	65	STRAND		might get lost (downstream of altered splice site)
69	76	STRAND		might get lost (downstream of altered splice site)
77	79	TURN		might get lost (downstream of altered splice site)
80	85	STRAND		might get lost (downstream of altered splice site)
91	95	STRAND		might get lost (downstream of altered splice site)
100	102	HELIX		might get lost (downstream of altered splice site)
104	110	STRAND		might get lost (downstream of altered splice site)
111	113	TURN		might get lost (downstream of altered splice site)
114	119	STRAND		might get lost (downstream of altered splice site)
120	122	TURN		might get lost (downstream of altered splice site)
125	128	STRAND		might get lost (downstream of altered splice site)
134	138	STRAND		might get lost (downstream of altered splice site)
143	145	HELIX		might get lost (downstream of altered splice site)
146	151	STRAND		might get lost (downstream of altered splice site)
155	155	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
157	164	STRAND		might get lost (downstream of altered splice site)
180	182	HELIX		might get lost (downstream of altered splice site)
188	190	HELIX		might get lost (downstream of altered splice site)
192	195	STRAND		might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

615 / 615

position (AA) of stopcodon in wt / mu AA sequence

205 / 205

position of stopcodon in wt / mu cDNA

689 / 689

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

75 / 75

chromosome

strand

-1

last intron/exon boundary

399

theoretical NMD boundary in CDS

274

length of CDS

615

coding sequence (CDS) position

178

cDNA position
(for ins/del: last normal base / first normal base)

252

gDNA position
(for ins/del: last normal base / first normal base)

1300

chromosomal position
(for ins/del: last normal base / first normal base)

103534528

original gDNA sequence snippet

ACGTGCAGGTCCTGGCCAACAAGCGCATCAACGCCATGGCA

altered gDNA sequence snippet

ACGTGCAGGTCCTGGCCAACGAGCGCATCAACGCCATGGCA

original cDNA sequence snippet

ACGTGCAGGTCCTGGCCAACAAGCGCATCAACGCCATGGCA

altered cDNA sequence snippet

ACGTGCAGGTCCTGGCCAACGAGCGCATCAACGCCATGGCA

wildtype AA sequence

MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK
RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE
IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF
EFLNYPPFTR SLRGSQRTWA PEPR*

mutated AA sequence

MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANE
RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE
IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF
EFLNYPPFTR SLRGSQRTWA PEPR*

speed

0.33 s

mutation t@sting

documentation

Prediction

disease causing

Model: simple_aae, prob: 0.999997235956533 (classification due to ClinVar, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
known disease mutation at this position (HGMD CM082675)
known disease mutation: rs9124 (pathogenic)
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr10:103534528T>CN/A show variant in all transcripts IGV

HGNC symbol

FGF8

Ensembl transcript ID

ENST00000347978

Genbank transcript ID

NM_006119

UniProt peptide

P55075

alteration type

single base exchange

alteration region

CDS

DNA changes

c.211A>G
cDNA.381A>G
g.1300A>G

AA changes

K71E Score: 56 explain score(s)

position(s) of altered AA
if AA alteration in CDS

frameshift

known variant

regulatory features

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	3.073	1
	4.677	1
(flanking)	5.662	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	1293	wt: 0.9010 / mu: 0.9127 (marginal change - not scored)	wt: GTCCTGGCCAACAAG mu: GTCCTGGCCAACGAG	CCTG\|gcca
Donor gained	1294	0.44	mu: TCCTGGCCAACGAGC	CTGG\|ccaa

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

mutated

all conserved

Ptroglodytes

all identical

ENSPTRG00000002874

100

Mmulatta

no alignment

ENSMMUG00000015771

n/a

Fcatus

not conserved

ENSFCAG00000007177

EKPLQ

Mmusculus

all identical

ENSMUSG00000025219

124

Ggallus

all identical

ENSGALG00000007706

Trubripes

no homologue

Drerio

all identical

ENSDARG00000003399

Dmelanogaster

not conserved

FBgn0014135

268

Celegans

no alignment

C05D11.4

n/a

Xtropicalis

all identical

ENSXETG00000014474

100

protein features

start (aa)	end (aa)	feature	details
69	76	STRAND		lost
77	79	TURN		might get lost (downstream of altered splice site)
80	85	STRAND		might get lost (downstream of altered splice site)
91	95	STRAND		might get lost (downstream of altered splice site)
100	102	HELIX		might get lost (downstream of altered splice site)
104	110	STRAND		might get lost (downstream of altered splice site)
111	113	TURN		might get lost (downstream of altered splice site)
114	119	STRAND		might get lost (downstream of altered splice site)
120	122	TURN		might get lost (downstream of altered splice site)
125	128	STRAND		might get lost (downstream of altered splice site)
134	138	STRAND		might get lost (downstream of altered splice site)
143	145	HELIX		might get lost (downstream of altered splice site)
146	151	STRAND		might get lost (downstream of altered splice site)
155	155	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
157	164	STRAND		might get lost (downstream of altered splice site)
180	182	HELIX		might get lost (downstream of altered splice site)
188	190	HELIX		might get lost (downstream of altered splice site)
192	195	STRAND		might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

648 / 648

position (AA) of stopcodon in wt / mu AA sequence

216 / 216

position of stopcodon in wt / mu cDNA

818 / 818

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

171 / 171

chromosome

strand

-1

last intron/exon boundary

528

theoretical NMD boundary in CDS

307

length of CDS

648

coding sequence (CDS) position

211

cDNA position
(for ins/del: last normal base / first normal base)

381

gDNA position
(for ins/del: last normal base / first normal base)

1300

chromosomal position
(for ins/del: last normal base / first normal base)

103534528

original gDNA sequence snippet

ACGTGCAGGTCCTGGCCAACAAGCGCATCAACGCCATGGCA

altered gDNA sequence snippet

ACGTGCAGGTCCTGGCCAACGAGCGCATCAACGCCATGGCA

original cDNA sequence snippet

ACGTGCAGGTCCTGGCCAACAAGCGCATCAACGCCATGGCA

altered cDNA sequence snippet

ACGTGCAGGTCCTGGCCAACGAGCGCATCAACGCCATGGCA

wildtype AA sequence

MGSPRSALSC LLLHLLVLCL QAQVTVQSSP NFTQHVREQS LVTDQLSRRL IRTYQLYSRT
SGKHVQVLAN KRINAMAEDG DPFAKLIVET DTFGSRVRVR GAETGLYICM NKKGKLIAKS
NGKGKDCVFT EIVLENNYTA LQNAKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPR
GHHTTEQSLR FEFLNYPPFT RSLRGSQRTW APEPR*

mutated AA sequence

MGSPRSALSC LLLHLLVLCL QAQVTVQSSP NFTQHVREQS LVTDQLSRRL IRTYQLYSRT
SGKHVQVLAN ERINAMAEDG DPFAKLIVET DTFGSRVRVR GAETGLYICM NKKGKLIAKS
NGKGKDCVFT EIVLENNYTA LQNAKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPR
GHHTTEQSLR FEFLNYPPFT RSLRGSQRTW APEPR*

speed

0.83 s

mutation t@sting

documentation

Prediction

disease causing

Model: simple_aae, prob: 0.999997945921173 (classification due to ClinVar, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
known disease mutation at this position (HGMD CM082675)
known disease mutation: rs9124 (pathogenic)
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr10:103534528T>CN/A show variant in all transcripts IGV

HGNC symbol

FGF8

Ensembl transcript ID

ENST00000320185

Genbank transcript ID

NM_033163

UniProt peptide

P55075

alteration type

single base exchange

alteration region

CDS

DNA changes

c.298A>G
cDNA.357A>G
g.1300A>G

AA changes

K100E Score: 56 explain score(s)

position(s) of altered AA
if AA alteration in CDS

100

frameshift

known variant

regulatory features

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	3.073	1
	4.677	1
(flanking)	5.662	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	1293	wt: 0.9010 / mu: 0.9127 (marginal change - not scored)	wt: GTCCTGGCCAACAAG mu: GTCCTGGCCAACGAG	CCTG\|gcca
Donor gained	1294	0.44	mu: TCCTGGCCAACGAGC	CTGG\|ccaa

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

100

mutated

all conserved

100

Ptroglodytes

all identical

ENSPTRG00000002874

100

Mmulatta

no alignment

ENSMMUG00000015771

n/a

Fcatus

not conserved

ENSFCAG00000007177

Mmusculus

all identical

ENSMUSG00000025219

124

Ggallus

all identical

ENSGALG00000007706

Trubripes

no homologue

Drerio

all identical

ENSDARG00000003399

Dmelanogaster

not conserved

FBgn0014135

268

Celegans

no alignment

C05D11.4

n/a

Xtropicalis

all identical

ENSXETG00000014474

100

protein features

start (aa)	end (aa)	feature	details
100	102	HELIX		lost
104	110	STRAND		might get lost (downstream of altered splice site)
111	113	TURN		might get lost (downstream of altered splice site)
114	119	STRAND		might get lost (downstream of altered splice site)
120	122	TURN		might get lost (downstream of altered splice site)
125	128	STRAND		might get lost (downstream of altered splice site)
134	138	STRAND		might get lost (downstream of altered splice site)
143	145	HELIX		might get lost (downstream of altered splice site)
146	151	STRAND		might get lost (downstream of altered splice site)
155	155	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
157	164	STRAND		might get lost (downstream of altered splice site)
180	182	HELIX		might get lost (downstream of altered splice site)
188	190	HELIX		might get lost (downstream of altered splice site)
192	195	STRAND		might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

735 / 735

position (AA) of stopcodon in wt / mu AA sequence

245 / 245

position of stopcodon in wt / mu cDNA

794 / 794

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

60 / 60

chromosome

strand

-1

last intron/exon boundary

504

theoretical NMD boundary in CDS

394

length of CDS

735

coding sequence (CDS) position

298

cDNA position
(for ins/del: last normal base / first normal base)

357

gDNA position
(for ins/del: last normal base / first normal base)

1300

chromosomal position
(for ins/del: last normal base / first normal base)

103534528

original gDNA sequence snippet

ACGTGCAGGTCCTGGCCAACAAGCGCATCAACGCCATGGCA

altered gDNA sequence snippet

ACGTGCAGGTCCTGGCCAACGAGCGCATCAACGCCATGGCA

original cDNA sequence snippet

ACGTGCAGGTCCTGGCCAACAAGCGCATCAACGCCATGGCA

altered cDNA sequence snippet

ACGTGCAGGTCCTGGCCAACGAGCGCATCAACGCCATGGCA

wildtype AA sequence

MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQVTVQSSPN
FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD
TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM
AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA
PEPR*

mutated AA sequence

MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQVTVQSSPN
FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANE RINAMAEDGD PFAKLIVETD
TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM
AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA
PEPR*

speed

0.83 s

MutationTaster - study a chromosomal position

Results

Taster files

mutation t@sting

Prediction

disease causing

mutation t@sting

Prediction

disease causing

mutation t@sting

Prediction

disease causing

mutation t@sting

Prediction

disease causing

Problems