MutationTaster - study a chromosomal position

NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 2 transcript(s)...
Querying Taster for transcript #1: ENST00000424728
Querying Taster for transcript #2: ENST00000343098
MT speed 0 s - this script 2.668219 s

Results

genesymbol	prediction	probability	model	prediction problem	splicing	ClinVar	amino acid changes	variant type	dbSNP ID	protein length	file
FSIP2	polymorphism_automatic	6.55333191046381e-07	simple_aae		affected		R6049H	single base exchange	rs1862066		show file
FSIP2	polymorphism_automatic	6.55333191046381e-07	simple_aae		affected		R5960H	single base exchange	rs1862066		show file

Taster files

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999999344666809 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr2:186671912G>AN/A show variant in all transcripts IGV

HGNC symbol

FSIP2

Ensembl transcript ID

ENST00000343098

Genbank transcript ID

NM_173651

UniProt peptide

Q5CZC0

alteration type

single base exchange

alteration region

CDS

DNA changes

c.18146G>A
cDNA.18146G>A
g.68558G>A

AA changes

R6049H Score: 29 explain score(s)

position(s) of altered AA
if AA alteration in CDS

6049

frameshift

known variant

Reference ID: rs1862066

database	homozygous (A/A)	heterozygous	allele carriers
1000G	753	1201	1954
ExAC	18346	-3925	14421

regulatory features

N/A

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	0.801	0.804
	0.575	0.824
(flanking)	0.178	0.835

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor increased	68562	wt: 0.78 / mu: 0.86	wt: CGTCAGGTTAACTTG mu: CATCAGGTTAACTTG	TCAG\|gtta
Donor gained	68561	0.31	mu: ACATCAGGTTAACTT	ATCA\|ggtt

distance from splice site

1949

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

6049

mutated

not conserved

6049

Ptroglodytes

not conserved

ENSPTRG00000039357

6048

Mmulatta

not conserved

ENSMMUG00000006109

637

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000075249

6057

Ggallus

no homologue

Trubripes

no homologue

Drerio

no homologue

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
6165	6165	CONFLICT	L -> Q (in Ref. 3; AK126051/BAC86406).	might get lost (downstream of altered splice site)
6526	6526	CONFLICT	G -> E (in Ref. 2; CAI46017).	might get lost (downstream of altered splice site)
6591	6591	CONFLICT	T -> I (in Ref. 2; BX648733).	might get lost (downstream of altered splice site)
6622	6622	CONFLICT	P -> S (in Ref. 2; CAI46017).	might get lost (downstream of altered splice site)
6644	6644	CONFLICT	V -> E (in Ref. 3; BAC86406).	might get lost (downstream of altered splice site)
6730	6730	CONFLICT	T -> I (in Ref. 2; BX648733).	might get lost (downstream of altered splice site)
6736	6736	CONFLICT	Q -> R (in Ref. 2; CAI46017).	might get lost (downstream of altered splice site)
6760	6760	CONFLICT	M -> V (in Ref. 2; BX648733).	might get lost (downstream of altered splice site)
6794	6794	CONFLICT	M -> V (in Ref. 2; BX648733).	might get lost (downstream of altered splice site)
6883	6883	CONFLICT	T -> A (in Ref. 2; BX648733/CAI46017 and 3; AK126051/BAC86406).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

20991 / 20991

position (AA) of stopcodon in wt / mu AA sequence

6997 / 6997

position of stopcodon in wt / mu cDNA

20991 / 20991

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

1 / 1

chromosome

strand

last intron/exon boundary

20855

theoretical NMD boundary in CDS

20804

length of CDS

20991

coding sequence (CDS) position

18146

cDNA position
(for ins/del: last normal base / first normal base)

18146

gDNA position
(for ins/del: last normal base / first normal base)

68558

chromosomal position
(for ins/del: last normal base / first normal base)

186671912

original gDNA sequence snippet

GATAAATGAAATTTTCCAACGTCAGGTTAACTTGATATTTT

altered gDNA sequence snippet

GATAAATGAAATTTTCCAACATCAGGTTAACTTGATATTTT

original cDNA sequence snippet

GATAAATGAAATTTTCCAACGTCAGGTTAACTTGATATTTT

altered cDNA sequence snippet

GATAAATGAAATTTTCCAACATCAGGTTAACTTGATATTTT

wildtype AA sequence

MKFQLWSSQI RPLGPIFPAL RALYALARAA PQEATALLGP LPLEAWNAGG GAEVVGLWPF
LVRSGQRDNG VLEKESGAGE EGAEGAVPAM ELYLGACSKP AKVAVTKTVA SVLAADTQQC
RDGVHKTHFA GVGPAQLLDL PLGVKLPVIP GSNAVFYTTN FGEKLFRPSY GFNLTDPYCR
LLENQYKSLH DPHLKAYYKR KDILKRLKKG GYITSNNKVV CTLRELNKYR QYLTSLKLDF
ERNYIKEQRI LAKQLHNIPE NNQIPQHCDV AQVQNWLLKE GTESIKDQER LMRHRYLDMI
SRKLEQLERT AEEQRLFLMD REERRQREHT RRKLTLRRKI EEEWKTKEML LLTRMAEDVK
REERIEEQQH RNREESDRKK QDLLEKKMAY HLQKMQDTGF NGEDIGKNTF KYRGQDGTHA
SPKNKKKTSE DIMLVYPAGD QNTYKETHGH TANAAHQRQN SSNNFTKKNS ASVVYQADVQ
DNGINQKRDG MVSKNSSIFD DRGGINISGQ GSIISAQVSP TRNFSRVSQA FLDPSKEEKE
TNADWDGRPT KRSSYLCESG PQAHATDPGI FSSPVYTNMQ QNLLQNCLQE KVTSEELNII
IQNVMTWVVA TVTSILYPAI TKYEKRLQNN TYPVSDDSIL SSDSSSFCST CSEDFTYRSY
TSATTKTFQA EPCAFVVDTS VRRPTTPIKP PPAHVEKTVV GKTCHIKGQS IISKHKYNKT
NLLYSYPKLR SCKSDSHLLA SFETGTKKSK DATTETDSLG SSLHCDKTAK AMDEMKNLKN
VFVNFKCYLK GETEVILESI LREIMSDLTQ AIPSLSSVTA EVFVEQCERE KEILLSNAHI
PSVASEIVEN MLEKLESAVE KKCVEMFSQD LSVDIKPSLA ASDELLTSSN GKPLKNSMPH
TLDPMCDIAE DMVHAILEKL MTLVSFKQNE FLHLKDTNKL SCQQHKTDPI CMFLQRAGKN
KSSLESDEAS LIVNEEVQNL ISNIFSQSSL VAYIEEAINA ILGYIQTELN NERIIASEET
VVLLQLLEDI LFQLHQEPVN ESFQKSRQPR ISSPSDTKEK YRLTGTRLSN SPRSGRPFPP
INVPGMVLYS DDENEEIDNI VKNVLDSTFK DEKVKSQEQI PNHWFTKGNT CFECKRNIKP
PTKPGSRSKA AFHDWELKTE PPSTNHEDIL KKKLSSNKDI STFSQDQKHQ IEKASENIVT
SILKEMLKDI SSVPFGHLDS KTGSEASVLV SEKPQGLSHQ EWIDQMFSVS EISTVAQEIT
DSVLNILHKA SNYISNTTKS SISSSVHQIS LHNSDTEHIV KEAPNKYPLK TWFDSEKKMK
YLSLFDVDPE KPPWLKSGKS EPKPVDDIND KIIRTIFKRL KSFICPKLHM GFKSSLRSQL
SKYTAKIVNI VLCAIQNELE LHKENLNLRE IDHTKSLTDK GFFANTDKKL ESLVTSIDDD
ILASPLLTCI YDMLLSSENA HQRSISLSSR KPKSATDSVD VQSILPNRQD KKSFHKYLAT
PCTHHSVNGG NHIKENAKLQ VLERIGETLH EMLSKLLGTH LHSQLSCSQQ SREMTNKNQK
MAAALQSNIQ LISKAILDYI LAKLCGVDMD TSFASCGLKA ISESLDIDNP SFASIIEKMA
KSTKIISSIV SRRVQEDNKE ETKSKAKPVA PVSSKTPSTK EMHPNKLKAV ASDILNMVFA
KLEGFANGHL EILGAINDGN KKSNKIGWEY ESTNISRDTH EASFLSALYM HAKKVSSAIL
KVIQTELNVT SSDLKTSVEN PPPETQILKY VVKLILDAVS SDMFNEMESE GGGIETYRYR
PTYGSLPGGA ESDSFLEDDA YTAKKIIDER SPQREEVKTR SLKQWALEKT LNKIEVKLKE
PHISPIAPII RNILNEIFQS TLINQLNVLS LSHSNFNGMP HNVDEPTPQT SVQFMDKMMD
PLLSEADITI VTDNIVRTVF HKLYSAAMTE RNVRENRYKT ITFSANVSSH EHTYKGKSSV
TALDENPCTF QSRFSVADKE TKVNLAEDIV QAILTNLETF ATSKVKSLFY SQVNFTVPVA
LPIQQDHSTL SKALSAKDSY SDEQFSCCSV DHTKSGKTNL CQLSLSKLNT YALQVARRNL
QGIKQELDKE RENPFLTHDI GISESIASQI VNALLDIISR KGKCDKNSSD KEIDLDQQKG
VIEKLLNETK YRKVLQLQIQ DTIEGILCDI YEKTLFQNNL SFATPTLKCS IADKHSEENS
EMFMEGANKI IPKLSVPKSD VILISNDIVN IVLHNLSSAA TLVINAKNPT SARLPLTFCD
TFPKIDCQQP LKGSKTERKT ERFSYSRNQK SAYADDNQIT VVEKEDTQKS ATDSCEENAN
FITKTIFKRL ESFATERIDS LITLAFQSKE KSFVIPELEN CKQNDSIFYD SSQVESDVNV
LKISATETIL SQELTDFTFV GRREKLGSTI HLSQARLKTY ADVIASAILK LIKNDLDLEI
QKIYPYQNNI LFQENIIVSE IVDSMLKMLD DKRSVKEICF NSKENSNFSQ LALSNEILLG
HKEKERSTKQ SLFTKYPLEQ NQMILENKRQ IIVLEEIFMR NGESKNKEKG ELLIAVEELL
NKLYQRVREV TGHLPPLNET ANFISNSKIK TSDTTQKNSF QSHINSVAND IVESVLGKMY
LVVVTSLYEN NKSRTEVEIS DHNDSLLMKP LRFRETKQAG KISNSPRYAI SQAYSYVDSQ
NISVMENTLL PYLPLQVKKD LIQMVLNKIT NFVSLPLKVS PKDNPKPCFK AHLKTRSKIT
TLPKFTKKTH LGLSAAKAKS KTKLGPGEKT LKDSRSKTAI GLSHIMSAGD AKNLLDTKLP
TSELKIYAKD IIINILETIV KEFGKVKQTK ALPSDQIIAA GKIVNTVLQE LYVTNNCNLA
YPMKSSHLRL SQGNIGTGSL PKQQACFYLE NVSSQLEHIF PREGIFKKLF DKWQTESNDK
ENEKCKLLMI AENVLTEISI KAKELEYSLS LLNLPPLENC ESRFYNHFKG ASTRAEDTKA
QINMFGREIV EMLLEKLQLC FLSQIPTPDS EETLSNSKEH ITAKSKYGFP NKHSLSSLPI
YNTKTKDQIS VGSSNQIVQE IVETVLNMLE SFVDLQFKHI SKYEFSEIVK MPIENLSSIQ
QKLLNKKMLP KLQPLKMFSD KSESNTINFK ENIQNILLRV HSFHSQLLTY AVNIISDMLA
VIKNKLDNEI SQMEPSSISI LKENIVASEI IGTLMDQCTY FNESLIQNLS RESLFQGAEN
AYTVNQVELA TNMKMFTSKL KEGSLGINPS QVSKTGFVFC SDEDMKEKYR VSSDLPTSVR
SSVEDTVKNS EPTKRPDSET MPSCSTRNKV QDHRPRESNF GSFDQTMKGN SYLPEGSFLQ
KLLRKASDST EAALKQVLSF IEMGKGENLR VFHYENLKPV VEPNQIQTTI SPLKICLAAE
NIVNTVLSSC GFPSQPHTNE NREIMKPFFI SKQSSLSEVS GGQKDNEKSL LRMQDKKINY
IPEEENENLE ASREDSSFLQ KLKKKEYPKI ETVKEVEAFT FADHEMGSNE VHLIARHVTT
SVVTYLKNFE TTVFSEEKMS VSTWSRKKYE SKQFLRNIYD DSSIYQCCEH LTESVLYHLT
SSISDGTKKG REKEKAWEIQ EATFSKIISI HSQVFESRSI SIGELALCIS EIIIKILFNN
KIIQADIAQK MVAIPTKYTY CPGIVSGGFD DLFQDLLVGV IHVLSKEIEV DYHFESNVRN
KSFSMHRNNS VPLCNKINRQ ASPRDWQFST QQIGQLFQKN KLSYLACKLN SLVGNLKTSE
SKEVVNKVFN IVSDLFSPDE CLDTGMDSGK IQRTYFYSSN NEQPNSILTN NLQLSSKSVF
LLNVVCEKLI RILLEECTST AFPDKGSVSE ETSAEECQLL KMLQSVEDGK SDYRKGGMDC
ECLQVDYMSD LLENVAEIDQ DLLTSDSMLT IISHSLVKSL MDKLSHSIQQ APESLPFANK
HLNYRTREIQ SSFIKARKSE LIELGQSKSS LELRSYDSNS LTVSLNNPSV VSSKIQAPFN
KHCAVKSSSV SPFERQRTKE MDKVAIHNKL HQEGIYAGVY SATFLEGIIS ELFFNLSMSL
WGKNKNITVS WLNEMNTLFV NNVVNEFNNA QVTVLRNAEE RLCFPPVHTE TVSKIVDSVY
YDVLQQYELK VACGNNPVYD NASIAEQITN GILLEILDYK LPSCFKEHLI PHSYYPLKPE
IILQKLQSNL TEFTSLPRSS SDYSTMLSHS FLEDVIRRLL SQLIPPPITC SSLGKKYLMS
SDFNEMSTCI INKVMSAISK HKIWFTIYDN QYLYTGKNLQ KMVDSVYCNI LQMSDSLVSI
QKSIVSRSPI MIDQIASFII QEIIENHLQP FLSGEVLCHP RTPLDPVSTI VTQVLSEVIE
SHRPQKQSPL DIHLDSFVRE IVARLLSKIF SPKHNTEIEL KNMTQRIVNS INRHFNKAKI
HILYDDKEQA FFSFNTDIVD ELATSVYRNA LKQHGLDLAV DKESEDSGIF VENITNLIVA
AISDYLLHPL FSGDFSASTY SNSVAENIVQ DILSNISKST EPSQSVPLYN TLLPYTFLED
MIRVLLSKLF SSASSLVLNR DTQKDISRVN FNDIASNLVS DIRMKVSQHE IRFSKEEEET
KFIYSEDDIQ HLVDSVFANV VQTSGSQESA VQNITSSNDI LIDRIAGFII KHICQKHLQP
FVSGKSLSSS DTYFDDERRQ LFYTSVYSST FLEDVISGVL RKIFHRVVGI VQTKSIRDSE
DELFEKAEEL IHLITGEFSK AQVSIIDNTE ERLCLPPVER DVVKTIVDMV YSKVLQEYEM
EVVPNKDFLN DTKTLAARIT NIILAEIFDF QIHPDLIANL PFKSHSKLSA NVLIQRVQYD
ISKSRFQRQA STMYTTMLSH SHLEKIVTQL TSQISPLNTS AEQSDTTKSD LSNTVIKLIN
EIMSIISKHE ICIIKYGNKK QSMISAKDIQ SMVDSIYADL SHSNIYQSIT KDKKSISDIP
VSKIASFIIK EIFNHHIQSF LSEDKTLLLA AVDQTYKLKA IDPKQRELSF IVNSSVFLEE
VISELLCKIL YAFSHNMLVT ENPDRVKLKL TRIVTTLVNS IVLEFTTSEI LVADNFDKNL
CFSERYKEMV QKIVNSVYGK VLDQYKSLIQ IHRVIQSDTI CFGRKIYYLL LEEIYDYQVQ
SLVSGELESS SYSYPQADNI IRNVLNIITK DSHALPPYIT VLPHSLLEDM VYRLLGHVFP
STHTENELKE KKFPPDDEFV EAASKLTDEI IKEISEHEIR LSMAEDNAES MQLEPIENLV
DSICNNILKT SEFQAEVQKD ADKKGCSFLS KLAGFIMKEI MYHHLQPFLH GEESSFSDLS
DYDHVSELAK SGKEKTQPSL YSATFLEDII IDLVHKFCSL LIITEDSKKN EMAELDIMGL
ALKLANSLIR EFKKSDIKVL PNAEKMFSFP PIDKETVDKI SNFVYEQFIE KCTSHDIQKG
DESNIAIGMI AALTQKAISA FRIQPLFSGD WSSTFFSFLN PDNITQRVQH LPQNTFTQIS
RCAKENQLSL PDQSYKDTSS TPDCKNMMST LEINRGTMNR KKSFKTKDTS VKKGDIQNPV
LSSINAIMKS GMINLTSGLA TGVTNKKEVD ENKVGICTQK HSENVSKVTS TTTVKSKDTQ
EPNLSETFNN NEIEKKRNLI PTDKKGKDDE IYTHFSLIID DTEYEKEVLG SDSEIGYKKK
IDNARESSFK KDDKLFQLSS LKSKRNLGTT TDTLEIRIRT SSNEGRRDSP TQTCRDEEHH
SDYEHVQNVI ENIFEDVLEL SSSPEPAYYS KLSYDQSPPG DNVLNVIQEI SRDSAQSVTT
KKVSSSTNKN ISAKEKEEEE REKEKVREEI KSEPSKPDDP QNQRESKPGI FPAKFLEDVI
TEMVKQLIFS SIPETQIQDR CQNVSDKQNQ AKLYDTAMKL INSLLKEFSD AQIKVFRPDK
GNQFPGGKVS SVPKVPPRYK EPTTDEAPSS IKIKSADKMP PMHKMMRKPS SDKIPSIDKT
LVNKVVHSSV CNILNDYGSQ DSIWKNINSN GENLARRLTS AVINEIFQRQ VNLIFCDEVS
VSACLPLESK DVVKKVQKLA QTASKECQTS SPYTIILPHK FLENVISALF SKIFSTISST
KTKEPEDNLS TELNFLQMKL VSAVATEISQ DKYMTIQYVE TLQSDDDEII QLVVQSVYNN
LLPQFGSQEI IQNCVTSGCK ILSENIVDLV LREVASNQLQ SYFCGELTPH QCVEVENIVE
KILKDVFQTT DVPLPKPSHA DKLSYNIIEE IAVKFLSKLL SIFPKVHKER TKSLETDMQK
ITSKVLNSVQ EFISKSKIKL VPPTKESPTV PVADNATIEN IVNSIYTSVL KHSGSYTSVF
KDLMGKSNVL SDTIGFLMVN AISNSEFQPQ VEEEVSNSEL VLEAVKIMEK VIKIIDELKS
KEKSSSRKGL TLDAKLLEEV LALFLAKLIR LPSSSSKDEK NLSKTELNKI ASQLSKLVTA
EISRSSISLI ASDPEEHCLN PENTERIYQV VDSVYSNILQ QSGTNKEFYY DIKDTNTAFP
KKVASLIIDG VSSFPLDTIN STISNADLSG ELDVNRIVQK AQEHAFNVIP ELEQEKLDQN
LSEEESPIKI VPHVGKKPVK IDPKIISEHL AVISIKTQPL EKLKQECLKR TGHSIAELRR
ASISGRNYSL GSPDLEKRKT ERRTSLDKTG RLDVKPLEAV ARNSFQNIRK PDITKVELLK
DVQSKNDLIV RLVAHDIDQV YLENYIKEER DSDEDEVVLT QTFAKEEGIK VFEDQVKEVK
KPIQSKLSPK STLSTSSLKK FLSLSKCCQT TASANIESTE AISNQVIESK ETHVKRAVAE
LDMATPKTMP ETASSSWEEK PQCKKEEKNL VTEPTHYFIH RIMSSSSYNQ EDLISSTGEA
EDCHSDPSAK ILEESSQEQK PEHGNSVKFI TIFERSKDVL GSANPSKEVI SETPKPDVSK
QGSKMLTKMS STLSKVFSQC NTNISRSSSP AHQDEH*

mutated AA sequence

MKFQLWSSQI RPLGPIFPAL RALYALARAA PQEATALLGP LPLEAWNAGG GAEVVGLWPF
LVRSGQRDNG VLEKESGAGE EGAEGAVPAM ELYLGACSKP AKVAVTKTVA SVLAADTQQC
RDGVHKTHFA GVGPAQLLDL PLGVKLPVIP GSNAVFYTTN FGEKLFRPSY GFNLTDPYCR
LLENQYKSLH DPHLKAYYKR KDILKRLKKG GYITSNNKVV CTLRELNKYR QYLTSLKLDF
ERNYIKEQRI LAKQLHNIPE NNQIPQHCDV AQVQNWLLKE GTESIKDQER LMRHRYLDMI
SRKLEQLERT AEEQRLFLMD REERRQREHT RRKLTLRRKI EEEWKTKEML LLTRMAEDVK
REERIEEQQH RNREESDRKK QDLLEKKMAY HLQKMQDTGF NGEDIGKNTF KYRGQDGTHA
SPKNKKKTSE DIMLVYPAGD QNTYKETHGH TANAAHQRQN SSNNFTKKNS ASVVYQADVQ
DNGINQKRDG MVSKNSSIFD DRGGINISGQ GSIISAQVSP TRNFSRVSQA FLDPSKEEKE
TNADWDGRPT KRSSYLCESG PQAHATDPGI FSSPVYTNMQ QNLLQNCLQE KVTSEELNII
IQNVMTWVVA TVTSILYPAI TKYEKRLQNN TYPVSDDSIL SSDSSSFCST CSEDFTYRSY
TSATTKTFQA EPCAFVVDTS VRRPTTPIKP PPAHVEKTVV GKTCHIKGQS IISKHKYNKT
NLLYSYPKLR SCKSDSHLLA SFETGTKKSK DATTETDSLG SSLHCDKTAK AMDEMKNLKN
VFVNFKCYLK GETEVILESI LREIMSDLTQ AIPSLSSVTA EVFVEQCERE KEILLSNAHI
PSVASEIVEN MLEKLESAVE KKCVEMFSQD LSVDIKPSLA ASDELLTSSN GKPLKNSMPH
TLDPMCDIAE DMVHAILEKL MTLVSFKQNE FLHLKDTNKL SCQQHKTDPI CMFLQRAGKN
KSSLESDEAS LIVNEEVQNL ISNIFSQSSL VAYIEEAINA ILGYIQTELN NERIIASEET
VVLLQLLEDI LFQLHQEPVN ESFQKSRQPR ISSPSDTKEK YRLTGTRLSN SPRSGRPFPP
INVPGMVLYS DDENEEIDNI VKNVLDSTFK DEKVKSQEQI PNHWFTKGNT CFECKRNIKP
PTKPGSRSKA AFHDWELKTE PPSTNHEDIL KKKLSSNKDI STFSQDQKHQ IEKASENIVT
SILKEMLKDI SSVPFGHLDS KTGSEASVLV SEKPQGLSHQ EWIDQMFSVS EISTVAQEIT
DSVLNILHKA SNYISNTTKS SISSSVHQIS LHNSDTEHIV KEAPNKYPLK TWFDSEKKMK
YLSLFDVDPE KPPWLKSGKS EPKPVDDIND KIIRTIFKRL KSFICPKLHM GFKSSLRSQL
SKYTAKIVNI VLCAIQNELE LHKENLNLRE IDHTKSLTDK GFFANTDKKL ESLVTSIDDD
ILASPLLTCI YDMLLSSENA HQRSISLSSR KPKSATDSVD VQSILPNRQD KKSFHKYLAT
PCTHHSVNGG NHIKENAKLQ VLERIGETLH EMLSKLLGTH LHSQLSCSQQ SREMTNKNQK
MAAALQSNIQ LISKAILDYI LAKLCGVDMD TSFASCGLKA ISESLDIDNP SFASIIEKMA
KSTKIISSIV SRRVQEDNKE ETKSKAKPVA PVSSKTPSTK EMHPNKLKAV ASDILNMVFA
KLEGFANGHL EILGAINDGN KKSNKIGWEY ESTNISRDTH EASFLSALYM HAKKVSSAIL
KVIQTELNVT SSDLKTSVEN PPPETQILKY VVKLILDAVS SDMFNEMESE GGGIETYRYR
PTYGSLPGGA ESDSFLEDDA YTAKKIIDER SPQREEVKTR SLKQWALEKT LNKIEVKLKE
PHISPIAPII RNILNEIFQS TLINQLNVLS LSHSNFNGMP HNVDEPTPQT SVQFMDKMMD
PLLSEADITI VTDNIVRTVF HKLYSAAMTE RNVRENRYKT ITFSANVSSH EHTYKGKSSV
TALDENPCTF QSRFSVADKE TKVNLAEDIV QAILTNLETF ATSKVKSLFY SQVNFTVPVA
LPIQQDHSTL SKALSAKDSY SDEQFSCCSV DHTKSGKTNL CQLSLSKLNT YALQVARRNL
QGIKQELDKE RENPFLTHDI GISESIASQI VNALLDIISR KGKCDKNSSD KEIDLDQQKG
VIEKLLNETK YRKVLQLQIQ DTIEGILCDI YEKTLFQNNL SFATPTLKCS IADKHSEENS
EMFMEGANKI IPKLSVPKSD VILISNDIVN IVLHNLSSAA TLVINAKNPT SARLPLTFCD
TFPKIDCQQP LKGSKTERKT ERFSYSRNQK SAYADDNQIT VVEKEDTQKS ATDSCEENAN
FITKTIFKRL ESFATERIDS LITLAFQSKE KSFVIPELEN CKQNDSIFYD SSQVESDVNV
LKISATETIL SQELTDFTFV GRREKLGSTI HLSQARLKTY ADVIASAILK LIKNDLDLEI
QKIYPYQNNI LFQENIIVSE IVDSMLKMLD DKRSVKEICF NSKENSNFSQ LALSNEILLG
HKEKERSTKQ SLFTKYPLEQ NQMILENKRQ IIVLEEIFMR NGESKNKEKG ELLIAVEELL
NKLYQRVREV TGHLPPLNET ANFISNSKIK TSDTTQKNSF QSHINSVAND IVESVLGKMY
LVVVTSLYEN NKSRTEVEIS DHNDSLLMKP LRFRETKQAG KISNSPRYAI SQAYSYVDSQ
NISVMENTLL PYLPLQVKKD LIQMVLNKIT NFVSLPLKVS PKDNPKPCFK AHLKTRSKIT
TLPKFTKKTH LGLSAAKAKS KTKLGPGEKT LKDSRSKTAI GLSHIMSAGD AKNLLDTKLP
TSELKIYAKD IIINILETIV KEFGKVKQTK ALPSDQIIAA GKIVNTVLQE LYVTNNCNLA
YPMKSSHLRL SQGNIGTGSL PKQQACFYLE NVSSQLEHIF PREGIFKKLF DKWQTESNDK
ENEKCKLLMI AENVLTEISI KAKELEYSLS LLNLPPLENC ESRFYNHFKG ASTRAEDTKA
QINMFGREIV EMLLEKLQLC FLSQIPTPDS EETLSNSKEH ITAKSKYGFP NKHSLSSLPI
YNTKTKDQIS VGSSNQIVQE IVETVLNMLE SFVDLQFKHI SKYEFSEIVK MPIENLSSIQ
QKLLNKKMLP KLQPLKMFSD KSESNTINFK ENIQNILLRV HSFHSQLLTY AVNIISDMLA
VIKNKLDNEI SQMEPSSISI LKENIVASEI IGTLMDQCTY FNESLIQNLS RESLFQGAEN
AYTVNQVELA TNMKMFTSKL KEGSLGINPS QVSKTGFVFC SDEDMKEKYR VSSDLPTSVR
SSVEDTVKNS EPTKRPDSET MPSCSTRNKV QDHRPRESNF GSFDQTMKGN SYLPEGSFLQ
KLLRKASDST EAALKQVLSF IEMGKGENLR VFHYENLKPV VEPNQIQTTI SPLKICLAAE
NIVNTVLSSC GFPSQPHTNE NREIMKPFFI SKQSSLSEVS GGQKDNEKSL LRMQDKKINY
IPEEENENLE ASREDSSFLQ KLKKKEYPKI ETVKEVEAFT FADHEMGSNE VHLIARHVTT
SVVTYLKNFE TTVFSEEKMS VSTWSRKKYE SKQFLRNIYD DSSIYQCCEH LTESVLYHLT
SSISDGTKKG REKEKAWEIQ EATFSKIISI HSQVFESRSI SIGELALCIS EIIIKILFNN
KIIQADIAQK MVAIPTKYTY CPGIVSGGFD DLFQDLLVGV IHVLSKEIEV DYHFESNVRN
KSFSMHRNNS VPLCNKINRQ ASPRDWQFST QQIGQLFQKN KLSYLACKLN SLVGNLKTSE
SKEVVNKVFN IVSDLFSPDE CLDTGMDSGK IQRTYFYSSN NEQPNSILTN NLQLSSKSVF
LLNVVCEKLI RILLEECTST AFPDKGSVSE ETSAEECQLL KMLQSVEDGK SDYRKGGMDC
ECLQVDYMSD LLENVAEIDQ DLLTSDSMLT IISHSLVKSL MDKLSHSIQQ APESLPFANK
HLNYRTREIQ SSFIKARKSE LIELGQSKSS LELRSYDSNS LTVSLNNPSV VSSKIQAPFN
KHCAVKSSSV SPFERQRTKE MDKVAIHNKL HQEGIYAGVY SATFLEGIIS ELFFNLSMSL
WGKNKNITVS WLNEMNTLFV NNVVNEFNNA QVTVLRNAEE RLCFPPVHTE TVSKIVDSVY
YDVLQQYELK VACGNNPVYD NASIAEQITN GILLEILDYK LPSCFKEHLI PHSYYPLKPE
IILQKLQSNL TEFTSLPRSS SDYSTMLSHS FLEDVIRRLL SQLIPPPITC SSLGKKYLMS
SDFNEMSTCI INKVMSAISK HKIWFTIYDN QYLYTGKNLQ KMVDSVYCNI LQMSDSLVSI
QKSIVSRSPI MIDQIASFII QEIIENHLQP FLSGEVLCHP RTPLDPVSTI VTQVLSEVIE
SHRPQKQSPL DIHLDSFVRE IVARLLSKIF SPKHNTEIEL KNMTQRIVNS INRHFNKAKI
HILYDDKEQA FFSFNTDIVD ELATSVYRNA LKQHGLDLAV DKESEDSGIF VENITNLIVA
AISDYLLHPL FSGDFSASTY SNSVAENIVQ DILSNISKST EPSQSVPLYN TLLPYTFLED
MIRVLLSKLF SSASSLVLNR DTQKDISRVN FNDIASNLVS DIRMKVSQHE IRFSKEEEET
KFIYSEDDIQ HLVDSVFANV VQTSGSQESA VQNITSSNDI LIDRIAGFII KHICQKHLQP
FVSGKSLSSS DTYFDDERRQ LFYTSVYSST FLEDVISGVL RKIFHRVVGI VQTKSIRDSE
DELFEKAEEL IHLITGEFSK AQVSIIDNTE ERLCLPPVER DVVKTIVDMV YSKVLQEYEM
EVVPNKDFLN DTKTLAARIT NIILAEIFDF QIHPDLIANL PFKSHSKLSA NVLIQRVQYD
ISKSRFQRQA STMYTTMLSH SHLEKIVTQL TSQISPLNTS AEQSDTTKSD LSNTVIKLIN
EIMSIISKHE ICIIKYGNKK QSMISAKDIQ SMVDSIYADL SHSNIYQSIT KDKKSISDIP
VSKIASFIIK EIFNHHIQSF LSEDKTLLLA AVDQTYKLKA IDPKQRELSF IVNSSVFLEE
VISELLCKIL YAFSHNMLVT ENPDRVKLKL TRIVTTLVNS IVLEFTTSEI LVADNFDKNL
CFSERYKEMV QKIVNSVYGK VLDQYKSLIQ IHRVIQSDTI CFGRKIYYLL LEEIYDYQVQ
SLVSGELESS SYSYPQADNI IRNVLNIITK DSHALPPYIT VLPHSLLEDM VYRLLGHVFP
STHTENELKE KKFPPDDEFV EAASKLTDEI IKEISEHEIR LSMAEDNAES MQLEPIENLV
DSICNNILKT SEFQAEVQKD ADKKGCSFLS KLAGFIMKEI MYHHLQPFLH GEESSFSDLS
DYDHVSELAK SGKEKTQPSL YSATFLEDII IDLVHKFCSL LIITEDSKKN EMAELDIMGL
ALKLANSLIR EFKKSDIKVL PNAEKMFSFP PIDKETVDKI SNFVYEQFIE KCTSHDIQKG
DESNIAIGMI AALTQKAISA FRIQPLFSGD WSSTFFSFLN PDNITQRVQH LPQNTFTQIS
RCAKENQLSL PDQSYKDTSS TPDCKNMMST LEINRGTMNR KKSFKTKDTS VKKGDIQNPV
LSSINAIMKS GMINLTSGLA TGVTNKKEVD ENKVGICTQK HSENVSKVTS TTTVKSKDTQ
EPNLSETFNN NEIEKKRNLI PTDKKGKDDE IYTHFSLIID DTEYEKEVLG SDSEIGYKKK
IDNARESSFK KDDKLFQLSS LKSKRNLGTT TDTLEIRIRT SSNEGRRDSP TQTCRDEEHH
SDYEHVQNVI ENIFEDVLEL SSSPEPAYYS KLSYDQSPPG DNVLNVIQEI SRDSAQSVTT
KKVSSSTNKN ISAKEKEEEE REKEKVREEI KSEPSKPDDP QNQRESKPGI FPAKFLEDVI
TEMVKQLIFS SIPETQIQDR CQNVSDKQNQ AKLYDTAMKL INSLLKEFSD AQIKVFRPDK
GNQFPGGKVS SVPKVPPRYK EPTTDEAPSS IKIKSADKMP PMHKMMRKPS SDKIPSIDKT
LVNKVVHSSV CNILNDYGSQ DSIWKNINSN GENLARRLTS AVINEIFQHQ VNLIFCDEVS
VSACLPLESK DVVKKVQKLA QTASKECQTS SPYTIILPHK FLENVISALF SKIFSTISST
KTKEPEDNLS TELNFLQMKL VSAVATEISQ DKYMTIQYVE TLQSDDDEII QLVVQSVYNN
LLPQFGSQEI IQNCVTSGCK ILSENIVDLV LREVASNQLQ SYFCGELTPH QCVEVENIVE
KILKDVFQTT DVPLPKPSHA DKLSYNIIEE IAVKFLSKLL SIFPKVHKER TKSLETDMQK
ITSKVLNSVQ EFISKSKIKL VPPTKESPTV PVADNATIEN IVNSIYTSVL KHSGSYTSVF
KDLMGKSNVL SDTIGFLMVN AISNSEFQPQ VEEEVSNSEL VLEAVKIMEK VIKIIDELKS
KEKSSSRKGL TLDAKLLEEV LALFLAKLIR LPSSSSKDEK NLSKTELNKI ASQLSKLVTA
EISRSSISLI ASDPEEHCLN PENTERIYQV VDSVYSNILQ QSGTNKEFYY DIKDTNTAFP
KKVASLIIDG VSSFPLDTIN STISNADLSG ELDVNRIVQK AQEHAFNVIP ELEQEKLDQN
LSEEESPIKI VPHVGKKPVK IDPKIISEHL AVISIKTQPL EKLKQECLKR TGHSIAELRR
ASISGRNYSL GSPDLEKRKT ERRTSLDKTG RLDVKPLEAV ARNSFQNIRK PDITKVELLK
DVQSKNDLIV RLVAHDIDQV YLENYIKEER DSDEDEVVLT QTFAKEEGIK VFEDQVKEVK
KPIQSKLSPK STLSTSSLKK FLSLSKCCQT TASANIESTE AISNQVIESK ETHVKRAVAE
LDMATPKTMP ETASSSWEEK PQCKKEEKNL VTEPTHYFIH RIMSSSSYNQ EDLISSTGEA
EDCHSDPSAK ILEESSQEQK PEHGNSVKFI TIFERSKDVL GSANPSKEVI SETPKPDVSK
QGSKMLTKMS STLSKVFSQC NTNISRSSSP AHQDEH*

speed

0.52 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999999344666809 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr2:186671912G>AN/A show variant in all transcripts IGV

HGNC symbol

FSIP2

Ensembl transcript ID

ENST00000424728

Genbank transcript ID

N/A

UniProt peptide

Q5CZC0

alteration type

single base exchange

alteration region

CDS

DNA changes

c.17879G>A
cDNA.17879G>A
g.68558G>A

AA changes

R5960H Score: 29 explain score(s)

position(s) of altered AA
if AA alteration in CDS

5960

frameshift

known variant

Reference ID: rs1862066

database	homozygous (A/A)	heterozygous	allele carriers
1000G	753	1201	1954
ExAC	18346	-3925	14421

regulatory features

N/A

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	0.801	0.804
	0.575	0.824
(flanking)	0.178	0.835

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor increased	68562	wt: 0.78 / mu: 0.86	wt: CGTCAGGTTAACTTG mu: CATCAGGTTAACTTG	TCAG\|gtta
Donor gained	68561	0.31	mu: ACATCAGGTTAACTT	ATCA\|ggtt

distance from splice site

1949

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

5960

mutated

not conserved

5960

Ptroglodytes

not conserved

ENSPTRG00000039357

6048

Mmulatta

not conserved

ENSMMUG00000006109

637

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000075249

6057

Ggallus

no homologue

Trubripes

no homologue

Drerio

no homologue

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
5960	5960	CONFLICT	R -> H (in Ref. 3; AK126051/BAC86406).	lost
6165	6165	CONFLICT	L -> Q (in Ref. 3; AK126051/BAC86406).	might get lost (downstream of altered splice site)
6526	6526	CONFLICT	G -> E (in Ref. 2; CAI46017).	might get lost (downstream of altered splice site)
6591	6591	CONFLICT	T -> I (in Ref. 2; BX648733).	might get lost (downstream of altered splice site)
6622	6622	CONFLICT	P -> S (in Ref. 2; CAI46017).	might get lost (downstream of altered splice site)
6644	6644	CONFLICT	V -> E (in Ref. 3; BAC86406).	might get lost (downstream of altered splice site)
6730	6730	CONFLICT	T -> I (in Ref. 2; BX648733).	might get lost (downstream of altered splice site)
6736	6736	CONFLICT	Q -> R (in Ref. 2; CAI46017).	might get lost (downstream of altered splice site)
6760	6760	CONFLICT	M -> V (in Ref. 2; BX648733).	might get lost (downstream of altered splice site)
6794	6794	CONFLICT	M -> V (in Ref. 2; BX648733).	might get lost (downstream of altered splice site)
6883	6883	CONFLICT	T -> A (in Ref. 2; BX648733/CAI46017 and 3; AK126051/BAC86406).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

20724 / 20724

position (AA) of stopcodon in wt / mu AA sequence

6908 / 6908

position of stopcodon in wt / mu cDNA

20724 / 20724

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

1 / 1

chromosome

strand

last intron/exon boundary

20588

theoretical NMD boundary in CDS

20537

length of CDS

20724

coding sequence (CDS) position

17879

cDNA position
(for ins/del: last normal base / first normal base)

17879

gDNA position
(for ins/del: last normal base / first normal base)

68558

chromosomal position
(for ins/del: last normal base / first normal base)

186671912

original gDNA sequence snippet

GATAAATGAAATTTTCCAACGTCAGGTTAACTTGATATTTT

altered gDNA sequence snippet

GATAAATGAAATTTTCCAACATCAGGTTAACTTGATATTTT

original cDNA sequence snippet

GATAAATGAAATTTTCCAACGTCAGGTTAACTTGATATTTT

altered cDNA sequence snippet

GATAAATGAAATTTTCCAACATCAGGTTAACTTGATATTTT

wildtype AA sequence

MELYLGACSK PAKVAVTKTV ASVLAADTQQ CRDGVHKTHF AGVGPAQLLD LPLGVKLPVI
PGSNAVFYTT NFGEKLFRPS YGFNLTDPYC RLLENQYKSL HDPHLKAYYK RKDILKRLKK
GGYITSNNKV VCTLRELNKY RQYLTSLKLD FERNYIKEQR ILAKQLHNIP ENNQIPQHCD
VAQVQNWLLK EGTESIKDQE RLMRHRYLDM ISRKLEQLER TAEEQRLFLM DREERRQREH
TRRKLTLRRK IEEEWKTKEM LLLTRMAEDV KREERIEEQQ HRNREESDRK KQDLLEKKMA
YHLQKMQDTG FNGEDIGKNT FKYRGQDGTH ASPKNKKKTS EDIMLVYPAG DQNTYKETHG
HTANAAHQRQ NSSNNFTKKN SASVVYQADV QDNGINQKRD GMVSKNSSIF DDRGGINISG
QGSIISAQVS PTRNFSRVSQ AFLDPSKEEK ETNADWDGRP TKRSSYLCES GPQAHATDPG
IFSSPVYTNM QQNLLQNCLQ EKVTSEELNI IIQNVMTWVV ATVTSILYPA ITKYEKRLQN
NTYPVSDDSI LSSDSSSFCS TCSEDFTYRS YTSATTKTFQ AEPCAFVVDT SVRRPTTPIK
PPPAHVEKTV VGKTCHIKGQ SIISKHKYNK TNLLYSYPKL RSCKSDSHLL ASFETGTKKS
KDATTETDSL GSSLHCDKTA KAMDEMKNLK NVFVNFKCYL KGETEVILES ILREIMSDLT
QAIPSLSSVT AEVFVEQCER EKEILLSNAH IPSVASEIVE NMLEKLESAV EKKCVEMFSQ
DLSVDIKPSL AASDELLTSS NGKPLKNSMP HTLDPMCDIA EDMVHAILEK LMTLVSFKQN
EFLHLKDTNK LSCQQHKTDP ICMFLQRAGK NKSSLESDEA SLIVNEEVQN LISNIFSQSS
LVAYIEEAIN AILGYIQTEL NNERIIASEE TVVLLQLLED ILFQLHQEPV NESFQKSRQP
RISSPSDTKE KYRLTGTRLS NSPRSGRPFP PINVPGMVLY SDDENEEIDN IVKNVLDSTF
KDEKVKSQEQ IPNHWFTKGN TCFECKRNIK PPTKPGSRSK AAFHDWELKT EPPSTNHEDI
LKKKLSSNKD ISTFSQDQKH QIEKASENIV TSILKEMLKD ISSVPFGHLD SKTGSEASVL
VSEKPQGLSH QEWIDQMFSV SEISTVAQEI TDSVLNILHK ASNYISNTTK SSISSSVHQI
SLHNSDTEHI VKEAPNKYPL KTWFDSEKKM KYLSLFDVDP EKPPWLKSGK SEPKPVDDIN
DKIIRTIFKR LKSFICPKLH MGFKSSLRSQ LSKYTAKIVN IVLCAIQNEL ELHKENLNLR
EIDHTKSLTD KGFFANTDKK LESLVTSIDD DILASPLLTC IYDMLLSSEN AHQRSISLSS
RKPKSATDSV DVQSILPNRQ DKKSFHKYLA TPCTHHSVNG GNHIKENAKL QVLERIGETL
HEMLSKLLGT HLHSQLSCSQ QSREMTNKNQ KMAAALQSNI QLISKAILDY ILAKLCGVDM
DTSFASCGLK AISESLDIDN PSFASIIEKM AKSTKIISSI VSRRVQEDNK EETKSKAKPV
APVSSKTPST KEMHPNKLKA VASDILNMVF AKLEGFANGH LEILGAINDG NKKSNKIGWE
YESTNISRDT HEASFLSALY MHAKKVSSAI LKVIQTELNV TSSDLKTSVE NPPPETQILK
YVVKLILDAV SSDMFNEMES EGGGIETYRY RPTYGSLPGG AESDSFLEDD AYTAKKIIDE
RSPQREEVKT RSLKQWALEK TLNKIEVKLK EPHISPIAPI IRNILNEIFQ STLINQLNVL
SLSHSNFNGM PHNVDEPTPQ TSVQFMDKMM DPLLSEADIT IVTDNIVRTV FHKLYSAAMT
ERNVRENRYK TITFSANVSS HEHTYKGKSS VTALDENPCT FQSRFSVADK ETKVNLAEDI
VQAILTNLET FATSKVKSLF YSQVNFTVPV ALPIQQDHST LSKALSAKDS YSDEQFSCCS
VDHTKSGKTN LCQLSLSKLN TYALQVARRN LQGIKQELDK ERENPFLTHD IGISESIASQ
IVNALLDIIS RKGKCDKNSS DKEIDLDQQK GVIEKLLNET KYRKVLQLQI QDTIEGILCD
IYEKTLFQNN LSFATPTLKC SIADKHSEEN SEMFMEGANK IIPKLSVPKS DVILISNDIV
NIVLHNLSSA ATLVINAKNP TSARLPLTFC DTFPKIDCQQ PLKGSKTERK TERFSYSRNQ
KSAYADDNQI TVVEKEDTQK SATDSCEENA NFITKTIFKR LESFATERID SLITLAFQSK
EKSFVIPELE NCKQNDSIFY DSSQVESDVN VLKISATETI LSQELTDFTF VGRREKLGST
IHLSQARLKT YADVIASAIL KLIKNDLDLE IQKIYPYQNN ILFQENIIVS EIVDSMLKML
DDKRSVKEIC FNSKENSNFS QLALSNEILL GHKEKERSTK QSLFTKYPLE QNQMILENKR
QIIVLEEIFM RNGESKNKEK GELLIAVEEL LNKLYQRVRE VTGHLPPLNE TANFISNSKI
KTSDTTQKNS FQSHINSVAN DIVESVLGKM YLVVVTSLYE NNKSRTEVEI SDHNDSLLMK
PLRFRETKQA GKISNSPRYA ISQAYSYVDS QNISVMENTL LPYLPLQVKK DLIQMVLNKI
TNFVSLPLKV SPKDNPKPCF KAHLKTRSKI TTLPKFTKKT HLGLSAAKAK SKTKLGPGEK
TLKDSRSKTA IGLSHIMSAG DAKNLLDTKL PTSELKIYAK DIIINILETI VKEFGKVKQT
KALPSDQIIA AGKIVNTVLQ ELYVTNNCNL AYPMKSSHLR LSQGNIGTGS LPKQQACFYL
ENVSSQLEHI FPREGIFKKL FDKWQTESND KENEKCKLLM IAENVLTEIS IKAKELEYSL
SLLNLPPLEN CESRFYNHFK GASTRAEDTK AQINMFGREI VEMLLEKLQL CFLSQIPTPD
SEETLSNSKE HITAKSKYGF PNKHSLSSLP IYNTKTKDQI SVGSSNQIVQ EIVETVLNML
ESFVDLQFKH ISKYEFSEIV KMPIENLSSI QQKLLNKKML PKLQPLKMFS DKSESNTINF
KENIQNILLR VHSFHSQLLT YAVNIISDML AVIKNKLDNE ISQMEPSSIS ILKENIVASE
IIGTLMDQCT YFNESLIQNL SRESLFQGAE NAYTVNQVEL ATNMKMFTSK LKEGSLGINP
SQVSKTGFVF CSDEDMKEKY RVSSDLPTSV RSSVEDTVKN SEPTKRPDSE TMPSCSTRNK
VQDHRPRESN FGSFDQTMKG NSYLPEGSFL QKLLRKASDS TEAALKQVLS FIEMGKGENL
RVFHYENLKP VVEPNQIQTT ISPLKICLAA ENIVNTVLSS CGFPSQPHTN ENREIMKPFF
ISKQSSLSEV SGGQKDNEKS LLRMQDKKIN YIPEEENENL EASREDSSFL QKLKKKEYPK
IETVKEVEAF TFADHEMGSN EVHLIARHVT TSVVTYLKNF ETTVFSEEKM SVSTWSRKKY
ESKQFLRNIY DDSSIYQCCE HLTESVLYHL TSSISDGTKK GREKEKAWEI QEATFSKIIS
IHSQVFESRS ISIGELALCI SEIIIKILFN NKIIQADIAQ KMVAIPTKYT YCPGIVSGGF
DDLFQDLLVG VIHVLSKEIE VDYHFESNVR NKSFSMHRNN SVPLCNKINR QASPRDWQFS
TQQIGQLFQK NKLSYLACKL NSLVGNLKTS ESKEVVNKVF NIVSDLFSPD ECLDTGMDSG
KIQRTYFYSS NNEQPNSILT NNLQLSSKSV FLLNVVCEKL IRILLEECTS TAFPDKGSVS
EETSAEECQL LKMLQSVEDG KSDYRKGGMD CECLQVDYMS DLLENVAEID QDLLTSDSML
TIISHSLVKS LMDKLSHSIQ QAPESLPFAN KHLNYRTREI QSSFIKARKS ELIELGQSKS
SLELRSYDSN SLTVSLNNPS VVSSKIQAPF NKHCAVKSSS VSPFERQRTK EMDKVAIHNK
LHQEGIYAGV YSATFLEGII SELFFNLSMS LWGKNKNITV SWLNEMNTLF VNNVVNEFNN
AQVTVLRNAE ERLCFPPVHT ETVSKIVDSV YYDVLQQYEL KVACGNNPVY DNASIAEQIT
NGILLEILDY KLPSCFKEHL IPHSYYPLKP EIILQKLQSN LTEFTSLPRS SSDYSTMLSH
SFLEDVIRRL LSQLIPPPIT CSSLGKKYLM SSDFNEMSTC IINKVMSAIS KHKIWFTIYD
NQYLYTGKNL QKMVDSVYCN ILQMSDSLVS IQKSIVSRSP IMIDQIASFI IQEIIENHLQ
PFLSGEVLCH PRTPLDPVST IVTQVLSEVI ESHRPQKQSP LDIHLDSFVR EIVARLLSKI
FSPKHNTEIE LKNMTQRIVN SINRHFNKAK IHILYDDKEQ AFFSFNTDIV DELATSVYRN
ALKQHGLDLA VDKESEDSGI FVENITNLIV AAISDYLLHP LFSGDFSAST YSNSVAENIV
QDILSNISKS TEPSQSVPLY NTLLPYTFLE DMIRVLLSKL FSSASSLVLN RDTQKDISRV
NFNDIASNLV SDIRMKVSQH EIRFSKEEEE TKFIYSEDDI QHLVDSVFAN VVQTSGSQES
AVQNITSSND ILIDRIAGFI IKHICQKHLQ PFVSGKSLSS SDTYFDDERR QLFYTSVYSS
TFLEDVISGV LRKIFHRVVG IVQTKSIRDS EDELFEKAEE LIHLITGEFS KAQVSIIDNT
EERLCLPPVE RDVVKTIVDM VYSKVLQEYE MEVVPNKDFL NDTKTLAARI TNIILAEIFD
FQIHPDLIAN LPFKSHSKLS ANVLIQRVQY DISKSRFQRQ ASTMYTTMLS HSHLEKIVTQ
LTSQISPLNT SAEQSDTTKS DLSNTVIKLI NEIMSIISKH EICIIKYGNK KQSMISAKDI
QSMVDSIYAD LSHSNIYQSI TKDKKSISDI PVSKIASFII KEIFNHHIQS FLSEDKTLLL
AAVDQTYKLK AIDPKQRELS FIVNSSVFLE EVISELLCKI LYAFSHNMLV TENPDRVKLK
LTRIVTTLVN SIVLEFTTSE ILVADNFDKN LCFSERYKEM VQKIVNSVYG KVLDQYKSLI
QIHRVIQSDT ICFGRKIYYL LLEEIYDYQV QSLVSGELES SSYSYPQADN IIRNVLNIIT
KDSHALPPYI TVLPHSLLED MVYRLLGHVF PSTHTENELK EKKFPPDDEF VEAASKLTDE
IIKEISEHEI RLSMAEDNAE SMQLEPIENL VDSICNNILK TSEFQAEVQK DADKKGCSFL
SKLAGFIMKE IMYHHLQPFL HGEESSFSDL SDYDHVSELA KSGKEKTQPS LYSATFLEDI
IIDLVHKFCS LLIITEDSKK NEMAELDIMG LALKLANSLI REFKKSDIKV LPNAEKMFSF
PPIDKETVDK ISNFVYEQFI EKCTSHDIQK GDESNIAIGM IAALTQKAIS AFRIQPLFSG
DWSSTFFSFL NPDNITQRVQ HLPQNTFTQI SRCAKENQLS LPDQSYKDTS STPDCKNMMS
TLEINRGTMN RKKSFKTKDT SVKKGDIQNP VLSSINAIMK SGMINLTSGL ATGVTNKKEV
DENKVGICTQ KHSENVSKVT STTTVKSKDT QEPNLSETFN NNEIEKKRNL IPTDKKGKDD
EIYTHFSLII DDTEYEKEVL GSDSEIGYKK KIDNARESSF KKDDKLFQLS SLKSKRNLGT
TTDTLEIRIR TSSNEGRRDS PTQTCRDEEH HSDYEHVQNV IENIFEDVLE LSSSPEPAYY
SKLSYDQSPP GDNVLNVIQE ISRDSAQSVT TKKVSSSTNK NISAKEKEEE EREKEKVREE
IKSEPSKPDD PQNQRESKPG IFPAKFLEDV ITEMVKQLIF SSIPETQIQD RCQNVSDKQN
QAKLYDTAMK LINSLLKEFS DAQIKVFRPD KGNQFPGGKV SSVPKVPPRY KEPTTDEAPS
SIKIKSADKM PPMHKMMRKP SSDKIPSIDK TLVNKVVHSS VCNILNDYGS QDSIWKNINS
NGENLARRLT SAVINEIFQR QVNLIFCDEV SVSACLPLES KDVVKKVQKL AQTASKECQT
SSPYTIILPH KFLENVISAL FSKIFSTISS TKTKEPEDNL STELNFLQMK LVSAVATEIS
QDKYMTIQYV ETLQSDDDEI IQLVVQSVYN NLLPQFGSQE IIQNCVTSGC KILSENIVDL
VLREVASNQL QSYFCGELTP HQCVEVENIV EKILKDVFQT TDVPLPKPSH ADKLSYNIIE
EIAVKFLSKL LSIFPKVHKE RTKSLETDMQ KITSKVLNSV QEFISKSKIK LVPPTKESPT
VPVADNATIE NIVNSIYTSV LKHSGSYTSV FKDLMGKSNV LSDTIGFLMV NAISNSEFQP
QVEEEVSNSE LVLEAVKIME KVIKIIDELK SKEKSSSRKG LTLDAKLLEE VLALFLAKLI
RLPSSSSKDE KNLSKTELNK IASQLSKLVT AEISRSSISL IASDPEEHCL NPENTERIYQ
VVDSVYSNIL QQSGTNKEFY YDIKDTNTAF PKKVASLIID GVSSFPLDTI NSTISNADLS
GELDVNRIVQ KAQEHAFNVI PELEQEKLDQ NLSEEESPIK IVPHVGKKPV KIDPKIISEH
LAVISIKTQP LEKLKQECLK RTGHSIAELR RASISGRNYS LGSPDLEKRK TERRTSLDKT
GRLDVKPLEA VARNSFQNIR KPDITKVELL KDVQSKNDLI VRLVAHDIDQ VYLENYIKEE
RDSDEDEVVL TQTFAKEEGI KVFEDQVKEV KKPIQSKLSP KSTLSTSSLK KFLSLSKCCQ
TTASANIEST EAISNQVIES KETHVKRAVA ELDMATPKTM PETASSSWEE KPQCKKEEKN
LVTEPTHYFI HRIMSSSSYN QEDLISSTGE AEDCHSDPSA KILEESSQEQ KPEHGNSVKF
ITIFERSKDV LGSANPSKEV ISETPKPDVS KQGSKMLTKM SSTLSKVFSQ CNTNISRSSS
PAHQDEH*

mutated AA sequence

MELYLGACSK PAKVAVTKTV ASVLAADTQQ CRDGVHKTHF AGVGPAQLLD LPLGVKLPVI
PGSNAVFYTT NFGEKLFRPS YGFNLTDPYC RLLENQYKSL HDPHLKAYYK RKDILKRLKK
GGYITSNNKV VCTLRELNKY RQYLTSLKLD FERNYIKEQR ILAKQLHNIP ENNQIPQHCD
VAQVQNWLLK EGTESIKDQE RLMRHRYLDM ISRKLEQLER TAEEQRLFLM DREERRQREH
TRRKLTLRRK IEEEWKTKEM LLLTRMAEDV KREERIEEQQ HRNREESDRK KQDLLEKKMA
YHLQKMQDTG FNGEDIGKNT FKYRGQDGTH ASPKNKKKTS EDIMLVYPAG DQNTYKETHG
HTANAAHQRQ NSSNNFTKKN SASVVYQADV QDNGINQKRD GMVSKNSSIF DDRGGINISG
QGSIISAQVS PTRNFSRVSQ AFLDPSKEEK ETNADWDGRP TKRSSYLCES GPQAHATDPG
IFSSPVYTNM QQNLLQNCLQ EKVTSEELNI IIQNVMTWVV ATVTSILYPA ITKYEKRLQN
NTYPVSDDSI LSSDSSSFCS TCSEDFTYRS YTSATTKTFQ AEPCAFVVDT SVRRPTTPIK
PPPAHVEKTV VGKTCHIKGQ SIISKHKYNK TNLLYSYPKL RSCKSDSHLL ASFETGTKKS
KDATTETDSL GSSLHCDKTA KAMDEMKNLK NVFVNFKCYL KGETEVILES ILREIMSDLT
QAIPSLSSVT AEVFVEQCER EKEILLSNAH IPSVASEIVE NMLEKLESAV EKKCVEMFSQ
DLSVDIKPSL AASDELLTSS NGKPLKNSMP HTLDPMCDIA EDMVHAILEK LMTLVSFKQN
EFLHLKDTNK LSCQQHKTDP ICMFLQRAGK NKSSLESDEA SLIVNEEVQN LISNIFSQSS
LVAYIEEAIN AILGYIQTEL NNERIIASEE TVVLLQLLED ILFQLHQEPV NESFQKSRQP
RISSPSDTKE KYRLTGTRLS NSPRSGRPFP PINVPGMVLY SDDENEEIDN IVKNVLDSTF
KDEKVKSQEQ IPNHWFTKGN TCFECKRNIK PPTKPGSRSK AAFHDWELKT EPPSTNHEDI
LKKKLSSNKD ISTFSQDQKH QIEKASENIV TSILKEMLKD ISSVPFGHLD SKTGSEASVL
VSEKPQGLSH QEWIDQMFSV SEISTVAQEI TDSVLNILHK ASNYISNTTK SSISSSVHQI
SLHNSDTEHI VKEAPNKYPL KTWFDSEKKM KYLSLFDVDP EKPPWLKSGK SEPKPVDDIN
DKIIRTIFKR LKSFICPKLH MGFKSSLRSQ LSKYTAKIVN IVLCAIQNEL ELHKENLNLR
EIDHTKSLTD KGFFANTDKK LESLVTSIDD DILASPLLTC IYDMLLSSEN AHQRSISLSS
RKPKSATDSV DVQSILPNRQ DKKSFHKYLA TPCTHHSVNG GNHIKENAKL QVLERIGETL
HEMLSKLLGT HLHSQLSCSQ QSREMTNKNQ KMAAALQSNI QLISKAILDY ILAKLCGVDM
DTSFASCGLK AISESLDIDN PSFASIIEKM AKSTKIISSI VSRRVQEDNK EETKSKAKPV
APVSSKTPST KEMHPNKLKA VASDILNMVF AKLEGFANGH LEILGAINDG NKKSNKIGWE
YESTNISRDT HEASFLSALY MHAKKVSSAI LKVIQTELNV TSSDLKTSVE NPPPETQILK
YVVKLILDAV SSDMFNEMES EGGGIETYRY RPTYGSLPGG AESDSFLEDD AYTAKKIIDE
RSPQREEVKT RSLKQWALEK TLNKIEVKLK EPHISPIAPI IRNILNEIFQ STLINQLNVL
SLSHSNFNGM PHNVDEPTPQ TSVQFMDKMM DPLLSEADIT IVTDNIVRTV FHKLYSAAMT
ERNVRENRYK TITFSANVSS HEHTYKGKSS VTALDENPCT FQSRFSVADK ETKVNLAEDI
VQAILTNLET FATSKVKSLF YSQVNFTVPV ALPIQQDHST LSKALSAKDS YSDEQFSCCS
VDHTKSGKTN LCQLSLSKLN TYALQVARRN LQGIKQELDK ERENPFLTHD IGISESIASQ
IVNALLDIIS RKGKCDKNSS DKEIDLDQQK GVIEKLLNET KYRKVLQLQI QDTIEGILCD
IYEKTLFQNN LSFATPTLKC SIADKHSEEN SEMFMEGANK IIPKLSVPKS DVILISNDIV
NIVLHNLSSA ATLVINAKNP TSARLPLTFC DTFPKIDCQQ PLKGSKTERK TERFSYSRNQ
KSAYADDNQI TVVEKEDTQK SATDSCEENA NFITKTIFKR LESFATERID SLITLAFQSK
EKSFVIPELE NCKQNDSIFY DSSQVESDVN VLKISATETI LSQELTDFTF VGRREKLGST
IHLSQARLKT YADVIASAIL KLIKNDLDLE IQKIYPYQNN ILFQENIIVS EIVDSMLKML
DDKRSVKEIC FNSKENSNFS QLALSNEILL GHKEKERSTK QSLFTKYPLE QNQMILENKR
QIIVLEEIFM RNGESKNKEK GELLIAVEEL LNKLYQRVRE VTGHLPPLNE TANFISNSKI
KTSDTTQKNS FQSHINSVAN DIVESVLGKM YLVVVTSLYE NNKSRTEVEI SDHNDSLLMK
PLRFRETKQA GKISNSPRYA ISQAYSYVDS QNISVMENTL LPYLPLQVKK DLIQMVLNKI
TNFVSLPLKV SPKDNPKPCF KAHLKTRSKI TTLPKFTKKT HLGLSAAKAK SKTKLGPGEK
TLKDSRSKTA IGLSHIMSAG DAKNLLDTKL PTSELKIYAK DIIINILETI VKEFGKVKQT
KALPSDQIIA AGKIVNTVLQ ELYVTNNCNL AYPMKSSHLR LSQGNIGTGS LPKQQACFYL
ENVSSQLEHI FPREGIFKKL FDKWQTESND KENEKCKLLM IAENVLTEIS IKAKELEYSL
SLLNLPPLEN CESRFYNHFK GASTRAEDTK AQINMFGREI VEMLLEKLQL CFLSQIPTPD
SEETLSNSKE HITAKSKYGF PNKHSLSSLP IYNTKTKDQI SVGSSNQIVQ EIVETVLNML
ESFVDLQFKH ISKYEFSEIV KMPIENLSSI QQKLLNKKML PKLQPLKMFS DKSESNTINF
KENIQNILLR VHSFHSQLLT YAVNIISDML AVIKNKLDNE ISQMEPSSIS ILKENIVASE
IIGTLMDQCT YFNESLIQNL SRESLFQGAE NAYTVNQVEL ATNMKMFTSK LKEGSLGINP
SQVSKTGFVF CSDEDMKEKY RVSSDLPTSV RSSVEDTVKN SEPTKRPDSE TMPSCSTRNK
VQDHRPRESN FGSFDQTMKG NSYLPEGSFL QKLLRKASDS TEAALKQVLS FIEMGKGENL
RVFHYENLKP VVEPNQIQTT ISPLKICLAA ENIVNTVLSS CGFPSQPHTN ENREIMKPFF
ISKQSSLSEV SGGQKDNEKS LLRMQDKKIN YIPEEENENL EASREDSSFL QKLKKKEYPK
IETVKEVEAF TFADHEMGSN EVHLIARHVT TSVVTYLKNF ETTVFSEEKM SVSTWSRKKY
ESKQFLRNIY DDSSIYQCCE HLTESVLYHL TSSISDGTKK GREKEKAWEI QEATFSKIIS
IHSQVFESRS ISIGELALCI SEIIIKILFN NKIIQADIAQ KMVAIPTKYT YCPGIVSGGF
DDLFQDLLVG VIHVLSKEIE VDYHFESNVR NKSFSMHRNN SVPLCNKINR QASPRDWQFS
TQQIGQLFQK NKLSYLACKL NSLVGNLKTS ESKEVVNKVF NIVSDLFSPD ECLDTGMDSG
KIQRTYFYSS NNEQPNSILT NNLQLSSKSV FLLNVVCEKL IRILLEECTS TAFPDKGSVS
EETSAEECQL LKMLQSVEDG KSDYRKGGMD CECLQVDYMS DLLENVAEID QDLLTSDSML
TIISHSLVKS LMDKLSHSIQ QAPESLPFAN KHLNYRTREI QSSFIKARKS ELIELGQSKS
SLELRSYDSN SLTVSLNNPS VVSSKIQAPF NKHCAVKSSS VSPFERQRTK EMDKVAIHNK
LHQEGIYAGV YSATFLEGII SELFFNLSMS LWGKNKNITV SWLNEMNTLF VNNVVNEFNN
AQVTVLRNAE ERLCFPPVHT ETVSKIVDSV YYDVLQQYEL KVACGNNPVY DNASIAEQIT
NGILLEILDY KLPSCFKEHL IPHSYYPLKP EIILQKLQSN LTEFTSLPRS SSDYSTMLSH
SFLEDVIRRL LSQLIPPPIT CSSLGKKYLM SSDFNEMSTC IINKVMSAIS KHKIWFTIYD
NQYLYTGKNL QKMVDSVYCN ILQMSDSLVS IQKSIVSRSP IMIDQIASFI IQEIIENHLQ
PFLSGEVLCH PRTPLDPVST IVTQVLSEVI ESHRPQKQSP LDIHLDSFVR EIVARLLSKI
FSPKHNTEIE LKNMTQRIVN SINRHFNKAK IHILYDDKEQ AFFSFNTDIV DELATSVYRN
ALKQHGLDLA VDKESEDSGI FVENITNLIV AAISDYLLHP LFSGDFSAST YSNSVAENIV
QDILSNISKS TEPSQSVPLY NTLLPYTFLE DMIRVLLSKL FSSASSLVLN RDTQKDISRV
NFNDIASNLV SDIRMKVSQH EIRFSKEEEE TKFIYSEDDI QHLVDSVFAN VVQTSGSQES
AVQNITSSND ILIDRIAGFI IKHICQKHLQ PFVSGKSLSS SDTYFDDERR QLFYTSVYSS
TFLEDVISGV LRKIFHRVVG IVQTKSIRDS EDELFEKAEE LIHLITGEFS KAQVSIIDNT
EERLCLPPVE RDVVKTIVDM VYSKVLQEYE MEVVPNKDFL NDTKTLAARI TNIILAEIFD
FQIHPDLIAN LPFKSHSKLS ANVLIQRVQY DISKSRFQRQ ASTMYTTMLS HSHLEKIVTQ
LTSQISPLNT SAEQSDTTKS DLSNTVIKLI NEIMSIISKH EICIIKYGNK KQSMISAKDI
QSMVDSIYAD LSHSNIYQSI TKDKKSISDI PVSKIASFII KEIFNHHIQS FLSEDKTLLL
AAVDQTYKLK AIDPKQRELS FIVNSSVFLE EVISELLCKI LYAFSHNMLV TENPDRVKLK
LTRIVTTLVN SIVLEFTTSE ILVADNFDKN LCFSERYKEM VQKIVNSVYG KVLDQYKSLI
QIHRVIQSDT ICFGRKIYYL LLEEIYDYQV QSLVSGELES SSYSYPQADN IIRNVLNIIT
KDSHALPPYI TVLPHSLLED MVYRLLGHVF PSTHTENELK EKKFPPDDEF VEAASKLTDE
IIKEISEHEI RLSMAEDNAE SMQLEPIENL VDSICNNILK TSEFQAEVQK DADKKGCSFL
SKLAGFIMKE IMYHHLQPFL HGEESSFSDL SDYDHVSELA KSGKEKTQPS LYSATFLEDI
IIDLVHKFCS LLIITEDSKK NEMAELDIMG LALKLANSLI REFKKSDIKV LPNAEKMFSF
PPIDKETVDK ISNFVYEQFI EKCTSHDIQK GDESNIAIGM IAALTQKAIS AFRIQPLFSG
DWSSTFFSFL NPDNITQRVQ HLPQNTFTQI SRCAKENQLS LPDQSYKDTS STPDCKNMMS
TLEINRGTMN RKKSFKTKDT SVKKGDIQNP VLSSINAIMK SGMINLTSGL ATGVTNKKEV
DENKVGICTQ KHSENVSKVT STTTVKSKDT QEPNLSETFN NNEIEKKRNL IPTDKKGKDD
EIYTHFSLII DDTEYEKEVL GSDSEIGYKK KIDNARESSF KKDDKLFQLS SLKSKRNLGT
TTDTLEIRIR TSSNEGRRDS PTQTCRDEEH HSDYEHVQNV IENIFEDVLE LSSSPEPAYY
SKLSYDQSPP GDNVLNVIQE ISRDSAQSVT TKKVSSSTNK NISAKEKEEE EREKEKVREE
IKSEPSKPDD PQNQRESKPG IFPAKFLEDV ITEMVKQLIF SSIPETQIQD RCQNVSDKQN
QAKLYDTAMK LINSLLKEFS DAQIKVFRPD KGNQFPGGKV SSVPKVPPRY KEPTTDEAPS
SIKIKSADKM PPMHKMMRKP SSDKIPSIDK TLVNKVVHSS VCNILNDYGS QDSIWKNINS
NGENLARRLT SAVINEIFQH QVNLIFCDEV SVSACLPLES KDVVKKVQKL AQTASKECQT
SSPYTIILPH KFLENVISAL FSKIFSTISS TKTKEPEDNL STELNFLQMK LVSAVATEIS
QDKYMTIQYV ETLQSDDDEI IQLVVQSVYN NLLPQFGSQE IIQNCVTSGC KILSENIVDL
VLREVASNQL QSYFCGELTP HQCVEVENIV EKILKDVFQT TDVPLPKPSH ADKLSYNIIE
EIAVKFLSKL LSIFPKVHKE RTKSLETDMQ KITSKVLNSV QEFISKSKIK LVPPTKESPT
VPVADNATIE NIVNSIYTSV LKHSGSYTSV FKDLMGKSNV LSDTIGFLMV NAISNSEFQP
QVEEEVSNSE LVLEAVKIME KVIKIIDELK SKEKSSSRKG LTLDAKLLEE VLALFLAKLI
RLPSSSSKDE KNLSKTELNK IASQLSKLVT AEISRSSISL IASDPEEHCL NPENTERIYQ
VVDSVYSNIL QQSGTNKEFY YDIKDTNTAF PKKVASLIID GVSSFPLDTI NSTISNADLS
GELDVNRIVQ KAQEHAFNVI PELEQEKLDQ NLSEEESPIK IVPHVGKKPV KIDPKIISEH
LAVISIKTQP LEKLKQECLK RTGHSIAELR RASISGRNYS LGSPDLEKRK TERRTSLDKT
GRLDVKPLEA VARNSFQNIR KPDITKVELL KDVQSKNDLI VRLVAHDIDQ VYLENYIKEE
RDSDEDEVVL TQTFAKEEGI KVFEDQVKEV KKPIQSKLSP KSTLSTSSLK KFLSLSKCCQ
TTASANIEST EAISNQVIES KETHVKRAVA ELDMATPKTM PETASSSWEE KPQCKKEEKN
LVTEPTHYFI HRIMSSSSYN QEDLISSTGE AEDCHSDPSA KILEESSQEQ KPEHGNSVKF
ITIFERSKDV LGSANPSKEV ISETPKPDVS KQGSKMLTKM SSTLSKVFSQ CNTNISRSSS
PAHQDEH*

speed

0.49 s

MutationTaster - study a chromosomal position

Results

Taster files

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

Problems