MutationTaster - study a chromosomal position

NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 5 transcript(s)...
Querying Taster for transcript #1: ENST00000426034
Querying Taster for transcript #2: ENST00000357203
Querying Taster for transcript #3: ENST00000449241
Querying Taster for transcript #4: ENST00000441239
Querying Taster for transcript #5: ENST00000422619
MT speed 0 s - this script 7.142146 s

Results

genesymbol	prediction	probability	model	prediction problem	splicing	ClinVar	amino acid changes	variant type	dbSNP ID	protein length	file
C3orf18	polymorphism_automatic	0.999993938224279	simple_aae		affected		A162V	single base exchange	rs1034405		show file
C3orf18	polymorphism_automatic	0.999993938224279	simple_aae		affected		A162V	single base exchange	rs1034405		show file
C3orf18	polymorphism_automatic	0.999993938224279	simple_aae		affected		A162V	single base exchange	rs1034405		show file
C3orf18	polymorphism_automatic	0.999993938224279	simple_aae		affected		A142V	single base exchange	rs1034405		show file
C3orf18	polymorphism_automatic	0.999993938224279	simple_aae		affected		A110V	single base exchange	rs1034405		show file

Taster files

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 6.06177572093911e-06 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:50597092G>AN/A show variant in all transcripts IGV

HGNC symbol

C3orf18

Ensembl transcript ID

ENST00000426034

Genbank transcript ID

NM_001171740

UniProt peptide

Q9UK00

alteration type

single base exchange

alteration region

CDS

DNA changes

c.485C>T
cDNA.850C>T
g.11367C>T

AA changes

A162V Score: 64 explain score(s)

position(s) of altered AA
if AA alteration in CDS

162

frameshift

known variant

Reference ID: rs1034405

database	homozygous (A/A)	heterozygous	allele carriers
1000G	1774	622	2396
ExAC	27687	-22607	5080

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-1.584	0.577
	5.085	1
(flanking)	3.521	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

splice site change occurs after stopcodon (at aa 164)

effect	gDNA position	score	detection sequence	exon-intron border
Acc increased	11371	wt: 0.56 / mu: 0.72	wt: GCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGCCTGG mu: GCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGCCTGG	gtga\|GTGG
Donor marginally increased	11360	wt: 0.8623 / mu: 0.9488 (marginal change - not scored)	wt: ATGCCATCCATGCGT mu: ATGCCATCCATGTGT	GCCA\|tcca

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

162

mutated

no alignment

n/a

Ptroglodytes

all identical

ENSPTRG00000014965

162

Mmulatta

all identical

ENSMMUG00000010499

162

Fcatus

all identical

ENSFCAG00000007017

162

Mmusculus

all identical

ENSMUSG00000037977

164

Ggallus

no homologue

Trubripes

all identical

ENSTRUG00000012231

168

Drerio

all identical

ENSDARG00000078609

119

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

no protein features affected

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

489 / 489

position (AA) of stopcodon in wt / mu AA sequence

163 / 163

position of stopcodon in wt / mu cDNA

854 / 854

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

366 / 366

chromosome

strand

-1

last intron/exon boundary

774

theoretical NMD boundary in CDS

358

length of CDS

489

coding sequence (CDS) position

485

cDNA position
(for ins/del: last normal base / first normal base)

850

gDNA position
(for ins/del: last normal base / first normal base)

11367

chromosomal position
(for ins/del: last normal base / first normal base)

50597092

original gDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered gDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

original cDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered cDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

wildtype AA sequence

MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVG
TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD
AASVQAATSV QAMQGKTTLP SQGPLQRPSR LVFTDVANAI HA*

mutated AA sequence

MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVG
TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD
AASVQAATSV QAMQGKTTLP SQGPLQRPSR LVFTDVANAI HV*

speed

1.15 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 6.06177572093911e-06 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:50597092G>AN/A show variant in all transcripts IGV

HGNC symbol

C3orf18

Ensembl transcript ID

ENST00000449241

Genbank transcript ID

NM_001171741

UniProt peptide

Q9UK00

alteration type

single base exchange

alteration region

CDS

DNA changes

c.485C>T
cDNA.736C>T
g.11367C>T

AA changes

A162V Score: 64 explain score(s)

position(s) of altered AA
if AA alteration in CDS

162

frameshift

known variant

Reference ID: rs1034405

database	homozygous (A/A)	heterozygous	allele carriers
1000G	1774	622	2396
ExAC	27687	-22607	5080

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-1.584	0.577
	5.085	1
(flanking)	3.521	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

splice site change occurs after stopcodon (at aa 164)

effect	gDNA position	score	detection sequence	exon-intron border
Acc increased	11371	wt: 0.56 / mu: 0.72	wt: GCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGCCTGG mu: GCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGCCTGG	gtga\|GTGG
Donor marginally increased	11360	wt: 0.8623 / mu: 0.9488 (marginal change - not scored)	wt: ATGCCATCCATGCGT mu: ATGCCATCCATGTGT	GCCA\|tcca

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

162

mutated

no alignment

n/a

Ptroglodytes

all identical

ENSPTRG00000014965

162

Mmulatta

all identical

ENSMMUG00000010499

162

Fcatus

all identical

ENSFCAG00000007017

162

Mmusculus

all identical

ENSMUSG00000037977

164

Ggallus

no homologue

Trubripes

all identical

ENSTRUG00000012231

168

Drerio

all identical

ENSDARG00000078609

119

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

no protein features affected

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

489 / 489

position (AA) of stopcodon in wt / mu AA sequence

163 / 163

position of stopcodon in wt / mu cDNA

740 / 740

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

252 / 252

chromosome

strand

-1

last intron/exon boundary

660

theoretical NMD boundary in CDS

358

length of CDS

489

coding sequence (CDS) position

485

cDNA position
(for ins/del: last normal base / first normal base)

736

gDNA position
(for ins/del: last normal base / first normal base)

11367

chromosomal position
(for ins/del: last normal base / first normal base)

50597092

original gDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered gDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

original cDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered cDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

wildtype AA sequence

MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVG
TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD
AASVQAATSV QAMQGKTTLP SQGPLQRPSR LVFTDVANAI HA*

mutated AA sequence

MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVG
TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD
AASVQAATSV QAMQGKTTLP SQGPLQRPSR LVFTDVANAI HV*

speed

1.30 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 6.06177572093911e-06 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:50597092G>AN/A show variant in all transcripts IGV

HGNC symbol

C3orf18

Ensembl transcript ID

ENST00000357203

Genbank transcript ID

NM_016210

UniProt peptide

Q9UK00

alteration type

single base exchange

alteration region

CDS

DNA changes

c.485C>T
cDNA.1025C>T
g.11367C>T

AA changes

A162V Score: 64 explain score(s)

position(s) of altered AA
if AA alteration in CDS

162

frameshift

known variant

Reference ID: rs1034405

database	homozygous (A/A)	heterozygous	allele carriers
1000G	1774	622	2396
ExAC	27687	-22607	5080

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-1.584	0.577
	5.085	1
(flanking)	3.521	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

splice site change occurs after stopcodon (at aa 164)

effect	gDNA position	score	detection sequence	exon-intron border
Acc increased	11371	wt: 0.56 / mu: 0.72	wt: GCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGCCTGG mu: GCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGCCTGG	gtga\|GTGG
Donor marginally increased	11360	wt: 0.8623 / mu: 0.9488 (marginal change - not scored)	wt: ATGCCATCCATGCGT mu: ATGCCATCCATGTGT	GCCA\|tcca

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

162

mutated

no alignment

n/a

Ptroglodytes

all identical

ENSPTRG00000014965

162

Mmulatta

all identical

ENSMMUG00000010499

162

Fcatus

all identical

ENSFCAG00000007017

162

Mmusculus

all identical

ENSMUSG00000037977

164

Ggallus

no homologue

Trubripes

all identical

ENSTRUG00000012231

168

Drerio

all identical

ENSDARG00000078609

119

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

no protein features affected

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

489 / 489

position (AA) of stopcodon in wt / mu AA sequence

163 / 163

position of stopcodon in wt / mu cDNA

1029 / 1029

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

541 / 541

chromosome

strand

-1

last intron/exon boundary

949

theoretical NMD boundary in CDS

358

length of CDS

489

coding sequence (CDS) position

485

cDNA position
(for ins/del: last normal base / first normal base)

1025

gDNA position
(for ins/del: last normal base / first normal base)

11367

chromosomal position
(for ins/del: last normal base / first normal base)

50597092

original gDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered gDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

original cDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered cDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

wildtype AA sequence

MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVG
TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD
AASVQAATSV QAMQGKTTLP SQGPLQRPSR LVFTDVANAI HA*

mutated AA sequence

MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVG
TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD
AASVQAATSV QAMQGKTTLP SQGPLQRPSR LVFTDVANAI HV*

speed

1.17 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 6.06177572093911e-06 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:50597092G>AN/A show variant in all transcripts IGV

HGNC symbol

C3orf18

Ensembl transcript ID

ENST00000441239

Genbank transcript ID

NM_001171743

UniProt peptide

Q9UK00

alteration type

single base exchange

alteration region

CDS

DNA changes

c.425C>T
cDNA.640C>T
g.11367C>T

AA changes

A142V Score: 64 explain score(s)

position(s) of altered AA
if AA alteration in CDS

142

frameshift

known variant

Reference ID: rs1034405

database	homozygous (A/A)	heterozygous	allele carriers
1000G	1774	622	2396
ExAC	27687	-22607	5080

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-1.584	0.577
	5.085	1
(flanking)	3.521	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

splice site change occurs after stopcodon (at aa 144)

effect	gDNA position	score	detection sequence	exon-intron border
Acc increased	11371	wt: 0.56 / mu: 0.72	wt: GCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGCCTGG mu: GCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGCCTGG	gtga\|GTGG
Donor marginally increased	11360	wt: 0.8623 / mu: 0.9488 (marginal change - not scored)	wt: ATGCCATCCATGCGT mu: ATGCCATCCATGTGT	GCCA\|tcca

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

142

mutated

no alignment

n/a

Ptroglodytes

all identical

ENSPTRG00000014965

162

Mmulatta

all identical

ENSMMUG00000010499

162

Fcatus

all identical

ENSFCAG00000007017

162

Mmusculus

all identical

ENSMUSG00000037977

164

Ggallus

no homologue

Trubripes

all identical

ENSTRUG00000012231

168

Drerio

all identical

ENSDARG00000078609

118

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

no protein features affected

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

429 / 429

position (AA) of stopcodon in wt / mu AA sequence

143 / 143

position of stopcodon in wt / mu cDNA

644 / 644

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

216 / 216

chromosome

strand

-1

last intron/exon boundary

564

theoretical NMD boundary in CDS

298

length of CDS

429

coding sequence (CDS) position

425

cDNA position
(for ins/del: last normal base / first normal base)

640

gDNA position
(for ins/del: last normal base / first normal base)

11367

chromosomal position
(for ins/del: last normal base / first normal base)

50597092

original gDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered gDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

original cDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered cDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

wildtype AA sequence

MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVL
YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD AASVQAATSV QAMQGKTTLP
SQGPLQRPSR LVFTDVANAI HA*

mutated AA sequence

MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVL
YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD AASVQAATSV QAMQGKTTLP
SQGPLQRPSR LVFTDVANAI HV*

speed

1.34 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 6.06177572093911e-06 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:50597092G>AN/A show variant in all transcripts IGV

HGNC symbol

C3orf18

Ensembl transcript ID

ENST00000422619

Genbank transcript ID

N/A

UniProt peptide

Q9UK00

alteration type

single base exchange

alteration region

CDS

DNA changes

c.329C>T
cDNA.415C>T
g.11367C>T

AA changes

A110V Score: 64 explain score(s)

position(s) of altered AA
if AA alteration in CDS

110

frameshift

known variant

Reference ID: rs1034405

database	homozygous (A/A)	heterozygous	allele carriers
1000G	1774	622	2396
ExAC	27687	-22607	5080

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-1.584	0.577
	5.085	1
(flanking)	3.521	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

splice site change occurs after stopcodon (at aa 112)

effect	gDNA position	score	detection sequence	exon-intron border
Acc increased	11371	wt: 0.56 / mu: 0.72	wt: GCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGCCTGG mu: GCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGCCTGG	gtga\|GTGG
Donor marginally increased	11360	wt: 0.8623 / mu: 0.9488 (marginal change - not scored)	wt: ATGCCATCCATGCGT mu: ATGCCATCCATGTGT	GCCA\|tcca

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

110

mutated

no alignment

n/a

Ptroglodytes

all identical

ENSPTRG00000014965

162

Mmulatta

all identical

ENSMMUG00000010499

162

Fcatus

all identical

ENSFCAG00000007017

162

Mmusculus

all identical

ENSMUSG00000037977

164

Ggallus

no homologue

Trubripes

all identical

ENSTRUG00000012231

168

Drerio

all identical

ENSDARG00000078609

118

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

no protein features affected

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

333 / 333

position (AA) of stopcodon in wt / mu AA sequence

111 / 111

position of stopcodon in wt / mu cDNA

419 / 419

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

87 / 87

chromosome

strand

-1

last intron/exon boundary

339

theoretical NMD boundary in CDS

202

length of CDS

333

coding sequence (CDS) position

329

cDNA position
(for ins/del: last normal base / first normal base)

415

gDNA position
(for ins/del: last normal base / first normal base)

11367

chromosomal position
(for ins/del: last normal base / first normal base)

50597092

original gDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered gDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

original cDNA sequence snippet

TGTGGCCAATGCCATCCATGCGTGAGTGGCCTGGGACAAGC

altered cDNA sequence snippet

TGTGGCCAATGCCATCCATGTGTGAGTGGCCTGGGACAAGC

wildtype AA sequence

MSPSRRAAGF LRASSPCHLM LLLLLQVLYI RKKKRLEKLR HQLMPMYNFD PTEEQDELEQ
ELLEHGRDAA SVQAATSVQA MQGKTTLPSQ GPLQRPSRLV FTDVANAIHA *

mutated AA sequence

MSPSRRAAGF LRASSPCHLM LLLLLQVLYI RKKKRLEKLR HQLMPMYNFD PTEEQDELEQ
ELLEHGRDAA SVQAATSVQA MQGKTTLPSQ GPLQRPSRLV FTDVANAIHV *

speed

1.34 s

MutationTaster - study a chromosomal position

Results

Taster files

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

Problems