MutationTaster - study a chromosomal position

NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 4 transcript(s)...
Querying Taster for transcript #1: ENST00000334268
Querying Taster for transcript #2: ENST00000398178
Querying Taster for transcript #3: ENST00000546248
Querying Taster for transcript #4: ENST00000542443
MT speed 0 s - this script 5.493446 s

Results

genesymbol	prediction	probability	model	prediction problem	splicing	ClinVar	amino acid changes	variant type	dbSNP ID	protein length	file
TRDN	polymorphism_automatic	5.38580410269773e-08	simple_aae		affected		T128S	single base exchange	rs9490809		show file
TRDN	polymorphism_automatic	2.23538226040709e-07	simple_aae		affected		T128S	single base exchange	rs9490809		show file
TRDN	polymorphism_automatic	2.39802036905434e-06	simple_aae		affected		T128S	single base exchange	rs9490809		show file
TRDN	polymorphism_automatic	2.39802036905434e-06	simple_aae		affected		T128S	single base exchange	rs9490809		show file

Taster files

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999999946141959 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:123869607G>CN/A show variant in all transcripts IGV

HGNC symbol

TRDN

Ensembl transcript ID

ENST00000546248

Genbank transcript ID

NM_001256020

UniProt peptide

Q13061

alteration type

single base exchange

alteration region

CDS

DNA changes

c.383C>G
cDNA.517C>G
g.88632C>G

AA changes

T128S Score: 58 explain score(s)

position(s) of altered AA
if AA alteration in CDS

128

frameshift

known variant

Reference ID: rs9490809

database	homozygous (C/C)	heterozygous	allele carriers
1000G	482	1004	1486
ExAC	8733	15301	24034

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-0.016	0.857
	0.314	0.868
(flanking)	0.993	0.882

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor gained	88631	0.79	mu: AAGATAGTGATAAAG	GATA\|gtga
Donor gained	88626	0.90	mu: TGACGAAGATAGTGA	ACGA\|agat

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

128

mutated

all conserved

128

Ptroglodytes

not conserved

ENSPTRG00000018567

186

Mmulatta

not conserved

ENSMMUG00000009725

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000019787

129

Ggallus

not conserved

ENSGALG00000014848

127

Trubripes

no homologue

Drerio

no homologue

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
69	729	TOPO_DOM	Lumenal.	lost
270	270	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
270	270	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
409	409	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
647	647	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
678	678	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
680	680	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
691	691	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
691	691	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

894 / 894

position (AA) of stopcodon in wt / mu AA sequence

298 / 298

position of stopcodon in wt / mu cDNA

1028 / 1028

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

135 / 135

chromosome

strand

-1

last intron/exon boundary

928

theoretical NMD boundary in CDS

743

length of CDS

894

coding sequence (CDS) position

383

cDNA position
(for ins/del: last normal base / first normal base)

517

gDNA position
(for ins/del: last normal base / first normal base)

88632

chromosomal position
(for ins/del: last normal base / first normal base)

123869607

original gDNA sequence snippet

TGATGATGGTGACGAAGATACTGATAAAGGTACAAAGAACA

altered gDNA sequence snippet

TGATGATGGTGACGAAGATAGTGATAAAGGTACAAAGAACA

original cDNA sequence snippet

TGATGATGGTGACGAAGATACTGATAAAGGAGAAATAGATG

altered cDNA sequence snippet

TGATGATGGTGACGAAGATAGTGATAAAGGAGAAATAGATG

wildtype AA sequence

mutated AA sequence

speed

0.88 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999999776461774 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:123869607G>CN/A show variant in all transcripts IGV

HGNC symbol

TRDN

Ensembl transcript ID

ENST00000542443

Genbank transcript ID

NM_001256022

UniProt peptide

Q13061

alteration type

single base exchange

alteration region

CDS

DNA changes

c.383C>G
cDNA.580C>G
g.88632C>G

AA changes

T128S Score: 58 explain score(s)

position(s) of altered AA
if AA alteration in CDS

128

frameshift

known variant

Reference ID: rs9490809

database	homozygous (C/C)	heterozygous	allele carriers
1000G	482	1004	1486
ExAC	8733	15301	24034

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-0.016	0.857
	0.314	0.868
(flanking)	0.993	0.882

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor gained	88631	0.79	mu: AAGATAGTGATAAAG	GATA\|gtga
Donor gained	88626	0.90	mu: TGACGAAGATAGTGA	ACGA\|agat

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

128

mutated

all conserved

128

Ptroglodytes

not conserved

ENSPTRG00000018567

186

Mmulatta

no alignment

ENSMMUG00000009725

n/a

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000019787

129

Ggallus

not conserved

ENSGALG00000014848

127

Trubripes

no homologue

Drerio

no homologue

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
69	729	TOPO_DOM	Lumenal.	lost
270	270	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
270	270	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
409	409	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
647	647	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
678	678	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
680	680	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
691	691	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
691	691	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

504 / 504

position (AA) of stopcodon in wt / mu AA sequence

168 / 168

position of stopcodon in wt / mu cDNA

701 / 701

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

198 / 198

chromosome

strand

-1

last intron/exon boundary

682

theoretical NMD boundary in CDS

434

length of CDS

504

coding sequence (CDS) position

383

cDNA position
(for ins/del: last normal base / first normal base)

580

gDNA position
(for ins/del: last normal base / first normal base)

88632

chromosomal position
(for ins/del: last normal base / first normal base)

123869607

original gDNA sequence snippet

TGATGATGGTGACGAAGATACTGATAAAGGTACAAAGAACA

altered gDNA sequence snippet

TGATGATGGTGACGAAGATAGTGATAAAGGTACAAAGAACA

original cDNA sequence snippet

TGATGATGGTGACGAAGATACTGATAAAGGAGAAATAGATG

altered cDNA sequence snippet

TGATGATGGTGACGAAGATAGTGATAAAGGAGAAATAGATG

wildtype AA sequence

MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW LLVIALIITW
SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAMEETT DWIYGFFSLL SDIISSEDEE
DDDGDEDTDK GEIDEPPLRK KEIHKDKTEK QEKPERKIQT KEVGHSS*

mutated AA sequence

MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW LLVIALIITW
SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAMEETT DWIYGFFSLL SDIISSEDEE
DDDGDEDSDK GEIDEPPLRK KEIHKDKTEK QEKPERKIQT KEVGHSS*

speed

1.25 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999997601979631 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:123869607G>CN/A show variant in all transcripts IGV

HGNC symbol

TRDN

Ensembl transcript ID

ENST00000334268

Genbank transcript ID

N/A

UniProt peptide

Q13061

alteration type

single base exchange

alteration region

CDS

DNA changes

c.383C>G
cDNA.701C>G
g.88632C>G

AA changes

T128S Score: 58 explain score(s)

position(s) of altered AA
if AA alteration in CDS

128

frameshift

known variant

Reference ID: rs9490809

database	homozygous (C/C)	heterozygous	allele carriers
1000G	482	1004	1486
ExAC	8733	15301	24034

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-0.016	0.857
	0.314	0.868
(flanking)	0.993	0.882

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor gained	88631	0.79	mu: AAGATAGTGATAAAG	GATA\|gtga
Donor gained	88626	0.90	mu: TGACGAAGATAGTGA	ACGA\|agat

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

128

mutated

all conserved

128

Ptroglodytes

no alignment

ENSPTRG00000018567

n/a

Mmulatta

no alignment

ENSMMUG00000009725

n/a

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000019787

129

Ggallus

not conserved

ENSGALG00000014848

127

Trubripes

no homologue

Drerio

no homologue

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
69	729	TOPO_DOM	Lumenal.	lost
270	270	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
270	270	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
409	409	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
647	647	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
678	678	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
680	680	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
691	691	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
691	691	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

2166 / 2166

position (AA) of stopcodon in wt / mu AA sequence

722 / 722

position of stopcodon in wt / mu cDNA

2484 / 2484

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

319 / 319

chromosome

strand

-1

last intron/exon boundary

2345

theoretical NMD boundary in CDS

1976

length of CDS

2166

coding sequence (CDS) position

383

cDNA position
(for ins/del: last normal base / first normal base)

701

gDNA position
(for ins/del: last normal base / first normal base)

88632

chromosomal position
(for ins/del: last normal base / first normal base)

123869607

original gDNA sequence snippet

TGATGATGGTGACGAAGATACTGATAAAGGTACAAAGAACA

altered gDNA sequence snippet

TGATGATGGTGACGAAGATAGTGATAAAGGTACAAAGAACA

original cDNA sequence snippet

TGATGATGGTGACGAAGATACTGATAAAGGAGAAATAGATG

altered cDNA sequence snippet

TGATGATGGTGACGAAGATAGTGATAAAGGAGAAATAGATG

wildtype AA sequence

MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW LLVIALIITW
SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAMEETT DWIYGFFSLL SDIISSEDEE
DDDGDEDTDK GEIDEPPLRK KEIHKDKTEK QEKPERKIQT KVTHKEKEKG KEKVREKEKP
EKKATHKEKI EKKEKPETKT LAKEQKKAKT AEKSEEKTKK EVKGGKQEKV KQTAAKVKEV
QKTPSKPKEK EDKEKAAVSK HEQKDQYAFC RYMIDIFVHG DLKPGQSPAI PPPLPTEQAS
RPTPASPALE EKEGEKKKAE KKVTSETKKK EKEDIKKKSE KETAIDVEKK EPGKASETKQ
GTVKIAAQAA AKKDEKKEDS KKTKKPAEVE QPKGKKQEKK EKHVEPAKSP KKEHSVPSDK
QVKAKTERAK EEIGAVSIKK AVPGKKEEKT TKTVEQEIRK EKSGKTSSIL KDKEPIKGKE
EKVPASLKEK EPETKKDEKM SKAGKEVKPK PPQLQGKKEE KPEPQIKKEA KPAISEKVQI
HKQDIVKPEK TVSHGKPEEK VLKQVKAVTI EKTAKPKPTK KAEHREREPP SIKTDKPKPT
PKGTSEVTES GKKKTEISEK ESKEKADMKH LREEKVSTRK ESLQLHNVTK EDVEDVPASK
KAKEGTEDVS PTKQKSPISF FQCVYLDGYN GYGFQFPFTP ADRPGESSGQ ANSPGQKQQG
Q*

mutated AA sequence

MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW LLVIALIITW
SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAMEETT DWIYGFFSLL SDIISSEDEE
DDDGDEDSDK GEIDEPPLRK KEIHKDKTEK QEKPERKIQT KVTHKEKEKG KEKVREKEKP
EKKATHKEKI EKKEKPETKT LAKEQKKAKT AEKSEEKTKK EVKGGKQEKV KQTAAKVKEV
QKTPSKPKEK EDKEKAAVSK HEQKDQYAFC RYMIDIFVHG DLKPGQSPAI PPPLPTEQAS
RPTPASPALE EKEGEKKKAE KKVTSETKKK EKEDIKKKSE KETAIDVEKK EPGKASETKQ
GTVKIAAQAA AKKDEKKEDS KKTKKPAEVE QPKGKKQEKK EKHVEPAKSP KKEHSVPSDK
QVKAKTERAK EEIGAVSIKK AVPGKKEEKT TKTVEQEIRK EKSGKTSSIL KDKEPIKGKE
EKVPASLKEK EPETKKDEKM SKAGKEVKPK PPQLQGKKEE KPEPQIKKEA KPAISEKVQI
HKQDIVKPEK TVSHGKPEEK VLKQVKAVTI EKTAKPKPTK KAEHREREPP SIKTDKPKPT
PKGTSEVTES GKKKTEISEK ESKEKADMKH LREEKVSTRK ESLQLHNVTK EDVEDVPASK
KAKEGTEDVS PTKQKSPISF FQCVYLDGYN GYGFQFPFTP ADRPGESSGQ ANSPGQKQQG
Q*

speed

1.20 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999997601979631 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:123869607G>CN/A show variant in all transcripts IGV

HGNC symbol

TRDN

Ensembl transcript ID

ENST00000398178

Genbank transcript ID

NM_006073

UniProt peptide

Q13061

alteration type

single base exchange

alteration region

CDS

DNA changes

c.383C>G
cDNA.405C>G
g.88632C>G

AA changes

T128S Score: 58 explain score(s)

position(s) of altered AA
if AA alteration in CDS

128

frameshift

known variant

Reference ID: rs9490809

database	homozygous (C/C)	heterozygous	allele carriers
1000G	482	1004	1486
ExAC	8733	15301	24034

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	-0.016	0.857
	0.314	0.868
(flanking)	0.993	0.882

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor gained	88631	0.79	mu: AAGATAGTGATAAAG	GATA\|gtga
Donor gained	88626	0.90	mu: TGACGAAGATAGTGA	ACGA\|agat

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

128

mutated

all conserved

128

Ptroglodytes

no alignment

ENSPTRG00000018567

n/a

Mmulatta

no alignment

ENSMMUG00000009725

n/a

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000019787

129

Ggallus

not conserved

ENSGALG00000014848

127

Trubripes

no homologue

Drerio

no homologue

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
69	729	TOPO_DOM	Lumenal.	lost
270	270	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
270	270	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
409	409	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
647	647	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
678	678	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
680	680	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
691	691	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)
691	691	DISULFID	Interchain (By similarity).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

2190 / 2190

position (AA) of stopcodon in wt / mu AA sequence

730 / 730

position of stopcodon in wt / mu cDNA

2212 / 2212

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

23 / 23

chromosome

strand

-1

last intron/exon boundary

2073

theoretical NMD boundary in CDS

2000

length of CDS

2190

coding sequence (CDS) position

383

cDNA position
(for ins/del: last normal base / first normal base)

405

gDNA position
(for ins/del: last normal base / first normal base)

88632

chromosomal position
(for ins/del: last normal base / first normal base)

123869607

original gDNA sequence snippet

TGATGATGGTGACGAAGATACTGATAAAGGTACAAAGAACA

altered gDNA sequence snippet

TGATGATGGTGACGAAGATAGTGATAAAGGTACAAAGAACA

original cDNA sequence snippet

TGATGATGGTGACGAAGATACTGATAAAGGAGAAATAGATG

altered cDNA sequence snippet

TGATGATGGTGACGAAGATAGTGATAAAGGAGAAATAGATG

wildtype AA sequence

MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW LLVIALIITW
SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAMEETT DWIYGFFSLL SDIISSEDEE
DDDGDEDTDK GEIDEPPLRK KEIHKDKTEK QEKPERKIQT KVTHKEKEKG KEKVREKEKP
EKKATHKEKI EKKEKPETKT LAKEQKKAKT AEKSEEKTKK EVKGGKQEKV KQTAAKVKEV
QKTPSKPKEK EDKEKAAVSK HEQKDQYAFC RYMIDIFVHG DLKPGQSPAI PPPLPTEQAS
RPTPASPALE EKEGEKKKAE KKVTSETKKK EKEDIKKKSE KETAIDVEKK EPGKASETKQ
GTVKIAAQAA AKKDEKKEDS KKTKKPAEVE QPKGKKQEKK EKHVEPAKSP KKEHSVPSDK
QVKAKTERAK EEIGAVSIKK AVPGKKEEKT TKTVEQEIRK EKSGKTSSIL KDKEPIKGKE
EKVPASLKEK EPETKKDEKM SKAGKEVKPK PPQLQGKKEE KPEPQIKKEA KPAISEKVQI
HKQDIVKPEK TVSHGKPEEK VLKQVKAVTI EKTAKPKPTK KAEHREREPP SIKTDKPKPT
PKGTSEVTES GKKKTEISEK ESKEKADMKH LREEKVSTRK ESLQLHNVTK AEKPARVSKD
VEDVPASKKA KEGTEDVSPT KQKSPISFFQ CVYLDGYNGY GFQFPFTPAD RPGESSGQAN
SPGQKQQGQ*

mutated AA sequence

MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW LLVIALIITW
SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAMEETT DWIYGFFSLL SDIISSEDEE
DDDGDEDSDK GEIDEPPLRK KEIHKDKTEK QEKPERKIQT KVTHKEKEKG KEKVREKEKP
EKKATHKEKI EKKEKPETKT LAKEQKKAKT AEKSEEKTKK EVKGGKQEKV KQTAAKVKEV
QKTPSKPKEK EDKEKAAVSK HEQKDQYAFC RYMIDIFVHG DLKPGQSPAI PPPLPTEQAS
RPTPASPALE EKEGEKKKAE KKVTSETKKK EKEDIKKKSE KETAIDVEKK EPGKASETKQ
GTVKIAAQAA AKKDEKKEDS KKTKKPAEVE QPKGKKQEKK EKHVEPAKSP KKEHSVPSDK
QVKAKTERAK EEIGAVSIKK AVPGKKEEKT TKTVEQEIRK EKSGKTSSIL KDKEPIKGKE
EKVPASLKEK EPETKKDEKM SKAGKEVKPK PPQLQGKKEE KPEPQIKKEA KPAISEKVQI
HKQDIVKPEK TVSHGKPEEK VLKQVKAVTI EKTAKPKPTK KAEHREREPP SIKTDKPKPT
PKGTSEVTES GKKKTEISEK ESKEKADMKH LREEKVSTRK ESLQLHNVTK AEKPARVSKD
VEDVPASKKA KEGTEDVSPT KQKSPISFFQ CVYLDGYNGY GFQFPFTPAD RPGESSGQAN
SPGQKQQGQ*

speed

1.29 s

MutationTaster - study a chromosomal position

Results

Taster files

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

Problems