MutationTaster - study a chromosomal position

NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 4 transcript(s)...
Querying Taster for transcript #1: ENST00000274897
Querying Taster for transcript #2: ENST00000514921
Querying Taster for transcript #3: ENST00000370877
Querying Taster for transcript #4: ENST00000509997
MT speed 0 s - this script 4.354577 s

Results

genesymbol	prediction	probability	model	prediction problem	splicing	ClinVar	amino acid changes	variant type	dbSNP ID	protein length	file
MLIP	polymorphism_automatic	0.000388670365096044	simple_aae		affected		R6H	single base exchange	rs17625497		show file
MLIP	polymorphism_automatic	0.000388670365096044	simple_aae		affected		R6H	single base exchange	rs17625497		show file
MLIP	polymorphism_automatic	0.000818860972958024	simple_aae		affected		R6H	single base exchange	rs17625497		show file
MLIP	polymorphism_automatic	0.000818860972958024	simple_aae		affected		R6H	single base exchange	rs17625497		show file

Taster files

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999611329634904 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:53883843G>AN/A show variant in all transcripts IGV

HGNC symbol

MLIP

Ensembl transcript ID

ENST00000370877

Genbank transcript ID

N/A

UniProt peptide

Q5VWP3

alteration type

single base exchange

alteration region

CDS

DNA changes

c.17G>A
cDNA.119G>A
g.89064G>A

AA changes

R6H Score: 29 explain score(s)

position(s) of altered AA
if AA alteration in CDS

frameshift

known variant

Reference ID: rs17625497

database	homozygous (A/A)	heterozygous	allele carriers
1000G	131	725	856
ExAC	4241	22022	26263

regulatory features

DNase1, Open Chromatin, DNase1 Hypersensitive Site

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	1.836	1
	1.321	1
(flanking)	1.31	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor increased	89065	wt: 0.84 / mu: 0.95	wt: AAGCGTGAAAAAAGA mu: AAGCATGAAAAAAGA	GCGT\|gaaa
Donor marginally increased	89067	wt: 0.9668 / mu: 0.9820 (marginal change - not scored)	wt: GCGTGAAAAAAGAAG mu: GCATGAAAAAAGAAG	GTGA\|aaaa
Donor marginally increased	89056	wt: 0.9952 / mu: 0.9953 (marginal change - not scored)	wt: GAACTTGAAAAGCGT mu: GAACTTGAAAAGCAT	ACTT\|gaaa

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

mutated

not conserved

Ptroglodytes

all identical

ENSPTRG00000018294

MVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIP

Mmulatta

not conserved

ENSMMUG00000012781

TVSAGGSEAKPLIFTFVPTVRRLPTHTQLTDTSKFLVKIP

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000032355

LKR

Ggallus

no homologue

Trubripes

no homologue

Drerio

no alignment

ENSDARG00000089920

n/a

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
1	40	REGION	Interaction with LMNA.	lost
355	355	CONFLICT	N -> T (in Ref. 3; AAH09010).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

807 / 807

position (AA) of stopcodon in wt / mu AA sequence

269 / 269

position of stopcodon in wt / mu cDNA

909 / 909

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

103 / 103

chromosome

strand

last intron/exon boundary

904

theoretical NMD boundary in CDS

751

length of CDS

807

coding sequence (CDS) position

cDNA position
(for ins/del: last normal base / first normal base)

119

gDNA position
(for ins/del: last normal base / first normal base)

89064

chromosomal position
(for ins/del: last normal base / first normal base)

53883843

original gDNA sequence snippet

CAATATGGAACTTGAAAAGCGTGAAAAAAGAAGCTTATTAA

altered gDNA sequence snippet

CAATATGGAACTTGAAAAGCATGAAAAAAGAAGCTTATTAA

original cDNA sequence snippet

CAATATGGAACTTGAAAAGCGTGAAAAAAGAAGCTTATTAA

altered cDNA sequence snippet

CAATATGGAACTTGAAAAGCATGAAAAAAGAAGCTTATTAA

wildtype AA sequence

MELEKREKRS LLNKNLEEKL TSKSNDYLTL NAGSQQERDQ AKLTCPSEVS GTILQEREFE
ANKLQGMQQS DLFKAEYVLI VDSEGEDEAA SRKVEQGPPG GIGTAAVRPK SLAISSSLVS
DVVRPKTQGT DLKTSSHPEM LHGMAPQQKH GQALDEPAKT ESVSKDNTLE PPVEHSSDSP
SRSPKTLLGS DTVKTPTTLP RAAGRETKYA NLSSPSSTVS ESQLTKPGVI RPVPVKSRIL
LKKEEEVYEP NPFSKYLEDN SDLFSEQQ*

mutated AA sequence

MELEKHEKRS LLNKNLEEKL TSKSNDYLTL NAGSQQERDQ AKLTCPSEVS GTILQEREFE
ANKLQGMQQS DLFKAEYVLI VDSEGEDEAA SRKVEQGPPG GIGTAAVRPK SLAISSSLVS
DVVRPKTQGT DLKTSSHPEM LHGMAPQQKH GQALDEPAKT ESVSKDNTLE PPVEHSSDSP
SRSPKTLLGS DTVKTPTTLP RAAGRETKYA NLSSPSSTVS ESQLTKPGVI RPVPVKSRIL
LKKEEEVYEP NPFSKYLEDN SDLFSEQQ*

speed

0.77 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999611329634904 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:53883843G>AN/A show variant in all transcripts IGV

HGNC symbol

MLIP

Ensembl transcript ID

ENST00000509997

Genbank transcript ID

N/A

UniProt peptide

Q5VWP3

alteration type

single base exchange

alteration region

CDS

DNA changes

c.17G>A
cDNA.46G>A
g.89064G>A

AA changes

R6H Score: 29 explain score(s)

position(s) of altered AA
if AA alteration in CDS

frameshift

known variant

Reference ID: rs17625497

database	homozygous (A/A)	heterozygous	allele carriers
1000G	131	725	856
ExAC	4241	22022	26263

regulatory features

DNase1, Open Chromatin, DNase1 Hypersensitive Site

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	1.836	1
	1.321	1
(flanking)	1.31	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor increased	89065	wt: 0.84 / mu: 0.95	wt: AAGCGTGAAAAAAGA mu: AAGCATGAAAAAAGA	GCGT\|gaaa
Donor marginally increased	89067	wt: 0.9668 / mu: 0.9820 (marginal change - not scored)	wt: GCGTGAAAAAAGAAG mu: GCATGAAAAAAGAAG	GTGA\|aaaa
Donor marginally increased	89056	wt: 0.9952 / mu: 0.9953 (marginal change - not scored)	wt: GAACTTGAAAAGCGT mu: GAACTTGAAAAGCAT	ACTT\|gaaa

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

mutated

not conserved

Ptroglodytes

all identical

ENSPTRG00000018294

MVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIP

Mmulatta

not conserved

ENSMMUG00000012781

TVSAGGSEAKPLIFTFVPTVRRLPTHTQLTDTSKFLVKIP

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000032355

LKR

Ggallus

no homologue

Trubripes

no homologue

Drerio

no alignment

ENSDARG00000089920

n/a

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
1	40	REGION	Interaction with LMNA.	lost
355	355	CONFLICT	N -> T (in Ref. 3; AAH09010).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

681 / 681

position (AA) of stopcodon in wt / mu AA sequence

227 / 227

position of stopcodon in wt / mu cDNA

710 / 710

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

30 / 30

chromosome

strand

last intron/exon boundary

705

theoretical NMD boundary in CDS

625

length of CDS

681

coding sequence (CDS) position

cDNA position
(for ins/del: last normal base / first normal base)

gDNA position
(for ins/del: last normal base / first normal base)

89064

chromosomal position
(for ins/del: last normal base / first normal base)

53883843

original gDNA sequence snippet

CAATATGGAACTTGAAAAGCGTGAAAAAAGAAGCTTATTAA

altered gDNA sequence snippet

CAATATGGAACTTGAAAAGCATGAAAAAAGAAGCTTATTAA

original cDNA sequence snippet

CAATATGGAACTTGAAAAGCGTGAAAAAAGAAGCTTATTAA

altered cDNA sequence snippet

CAATATGGAACTTGAAAAGCATGAAAAAAGAAGCTTATTAA

wildtype AA sequence

MELEKREKRS LLNKNLEEKL TSKSNDYLTL NAGSQQERDQ AKLTCPSEVS GTILQEREFE
ANKLQGMQQS DLFKAEYVLI VDSEGEDEAA SRKVEQGPPG GIGTAAVRPK SLAISSSLVS
DVVRPKTQGT DLKTSSHPEM LHGMAPQQKH GQTPTTLPRA AGRETKYANL SSPSSTVSES
QLTKPGVIRP VPVKSRILLK KEEEVYEPNP FSKYLEDNSD LFSEQQ*

mutated AA sequence

MELEKHEKRS LLNKNLEEKL TSKSNDYLTL NAGSQQERDQ AKLTCPSEVS GTILQEREFE
ANKLQGMQQS DLFKAEYVLI VDSEGEDEAA SRKVEQGPPG GIGTAAVRPK SLAISSSLVS
DVVRPKTQGT DLKTSSHPEM LHGMAPQQKH GQTPTTLPRA AGRETKYANL SSPSSTVSES
QLTKPGVIRP VPVKSRILLK KEEEVYEPNP FSKYLEDNSD LFSEQQ*

speed

0.71 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999181139027042 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:53883843G>AN/A show variant in all transcripts IGV

HGNC symbol

MLIP

Ensembl transcript ID

ENST00000274897

Genbank transcript ID

NM_138569

UniProt peptide

Q5VWP3

alteration type

single base exchange

alteration region

CDS

DNA changes

c.17G>A
cDNA.130G>A
g.89064G>A

AA changes

R6H Score: 29 explain score(s)

position(s) of altered AA
if AA alteration in CDS

frameshift

known variant

Reference ID: rs17625497

database	homozygous (A/A)	heterozygous	allele carriers
1000G	131	725	856
ExAC	4241	22022	26263

regulatory features

DNase1, Open Chromatin, DNase1 Hypersensitive Site

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	1.836	1
	1.321	1
(flanking)	1.31	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor increased	89065	wt: 0.84 / mu: 0.95	wt: AAGCGTGAAAAAAGA mu: AAGCATGAAAAAAGA	GCGT\|gaaa
Donor marginally increased	89067	wt: 0.9668 / mu: 0.9820 (marginal change - not scored)	wt: GCGTGAAAAAAGAAG mu: GCATGAAAAAAGAAG	GTGA\|aaaa
Donor marginally increased	89056	wt: 0.9952 / mu: 0.9953 (marginal change - not scored)	wt: GAACTTGAAAAGCGT mu: GAACTTGAAAAGCAT	ACTT\|gaaa

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

mutated

not conserved

Ptroglodytes

all identical

ENSPTRG00000018294

Mmulatta

not conserved

ENSMMUG00000012781

Fcatus

no homologue

Mmusculus

no alignment

ENSMUSG00000032355

n/a

Ggallus

no homologue

Trubripes

no homologue

Drerio

no alignment

ENSDARG00000089920

n/a

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
1	40	REGION	Interaction with LMNA.	lost
355	355	CONFLICT	N -> T (in Ref. 3; AAH09010).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

1377 / 1377

position (AA) of stopcodon in wt / mu AA sequence

459 / 459

position of stopcodon in wt / mu cDNA

1490 / 1490

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

114 / 114

chromosome

strand

last intron/exon boundary

1485

theoretical NMD boundary in CDS

1321

length of CDS

1377

coding sequence (CDS) position

cDNA position
(for ins/del: last normal base / first normal base)

130

gDNA position
(for ins/del: last normal base / first normal base)

89064

chromosomal position
(for ins/del: last normal base / first normal base)

53883843

original gDNA sequence snippet

CAATATGGAACTTGAAAAGCGTGAAAAAAGAAGCTTATTAA

altered gDNA sequence snippet

CAATATGGAACTTGAAAAGCATGAAAAAAGAAGCTTATTAA

original cDNA sequence snippet

CAATATGGAACTTGAAAAGCGTGAAAAAAGAAGCTTATTAA

altered cDNA sequence snippet

CAATATGGAACTTGAAAAGCATGAAAAAAGAAGCTTATTAA

wildtype AA sequence

MELEKREKRS LLNKNLEEKL TVSAGGSEAK PLIFTFVPTV RRLPTHTQLA DTSKFLVKIP
EESSDKSPET VNRSKSNDYL TLNAGSQQER DQAKLTCPSE VSGTILQERE FEANKLQGMQ
QSDLFKAEYV LIVDSEGEDE AASRKVEQGP PGGIGTAAVR PKSLAISSSL VSDVVRPKTQ
GTDLKTSSHP EMLHGMAPQQ KHGQQYKTKS SYKAFAAIPT NTLLLEQKAL DEPAKTESVS
KDNTLEPPVE LYFPAQLRQQ TEELCATIDK VLQDSLSMHS SDSPSRSPKT LLGSDTVKTP
TTLPRAAGRE TKYANLSSPS STVSESQLTK PGVIRPVPVK SRILLKKEEE VYEPNPFSKY
LEDNSDLFSE QDVTVPPKPV SLHPLYQTKL YPPAKSLLHP QTLSHADCLA PGPFSHLSFS
LSDEQENSHT LLSHNACNKL SHPMVAIPEH EALDSKEQ*

mutated AA sequence

MELEKHEKRS LLNKNLEEKL TVSAGGSEAK PLIFTFVPTV RRLPTHTQLA DTSKFLVKIP
EESSDKSPET VNRSKSNDYL TLNAGSQQER DQAKLTCPSE VSGTILQERE FEANKLQGMQ
QSDLFKAEYV LIVDSEGEDE AASRKVEQGP PGGIGTAAVR PKSLAISSSL VSDVVRPKTQ
GTDLKTSSHP EMLHGMAPQQ KHGQQYKTKS SYKAFAAIPT NTLLLEQKAL DEPAKTESVS
KDNTLEPPVE LYFPAQLRQQ TEELCATIDK VLQDSLSMHS SDSPSRSPKT LLGSDTVKTP
TTLPRAAGRE TKYANLSSPS STVSESQLTK PGVIRPVPVK SRILLKKEEE VYEPNPFSKY
LEDNSDLFSE QDVTVPPKPV SLHPLYQTKL YPPAKSLLHP QTLSHADCLA PGPFSHLSFS
LSDEQENSHT LLSHNACNKL SHPMVAIPEH EALDSKEQ*

speed

0.75 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999181139027042 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:53883843G>AN/A show variant in all transcripts IGV

HGNC symbol

MLIP

Ensembl transcript ID

ENST00000514921

Genbank transcript ID

N/A

UniProt peptide

Q5VWP3

alteration type

single base exchange

alteration region

CDS

DNA changes

c.17G>A
cDNA.130G>A
g.89064G>A

AA changes

R6H Score: 29 explain score(s)

position(s) of altered AA
if AA alteration in CDS

frameshift

known variant

Reference ID: rs17625497

database	homozygous (A/A)	heterozygous	allele carriers
1000G	131	725	856
ExAC	4241	22022	26263

regulatory features

DNase1, Open Chromatin, DNase1 Hypersensitive Site

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	1.836	1
	1.321	1
(flanking)	1.31	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor increased	89065	wt: 0.84 / mu: 0.95	wt: AAGCGTGAAAAAAGA mu: AAGCATGAAAAAAGA	GCGT\|gaaa
Donor marginally increased	89067	wt: 0.9668 / mu: 0.9820 (marginal change - not scored)	wt: GCGTGAAAAAAGAAG mu: GCATGAAAAAAGAAG	GTGA\|aaaa
Donor marginally increased	89056	wt: 0.9952 / mu: 0.9953 (marginal change - not scored)	wt: GAACTTGAAAAGCGT mu: GAACTTGAAAAGCAT	ACTT\|gaaa

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

mutated

not conserved

Ptroglodytes

all identical

ENSPTRG00000018294

Mmulatta

not conserved

ENSMMUG00000012781

Fcatus

no homologue

Mmusculus

no alignment

ENSMUSG00000032355

n/a

Ggallus

no homologue

Trubripes

no homologue

Drerio

no alignment

ENSDARG00000089920

n/a

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
1	40	REGION	Interaction with LMNA.	lost
355	355	CONFLICT	N -> T (in Ref. 3; AAH09010).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

2748 / 2748

position (AA) of stopcodon in wt / mu AA sequence

916 / 916

position of stopcodon in wt / mu cDNA

2861 / 2861

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

114 / 114

chromosome

strand

last intron/exon boundary

2799

theoretical NMD boundary in CDS

2635

length of CDS

2748

coding sequence (CDS) position

cDNA position
(for ins/del: last normal base / first normal base)

130

gDNA position
(for ins/del: last normal base / first normal base)

89064

chromosomal position
(for ins/del: last normal base / first normal base)

53883843

original gDNA sequence snippet

CAATATGGAACTTGAAAAGCGTGAAAAAAGAAGCTTATTAA

altered gDNA sequence snippet

CAATATGGAACTTGAAAAGCATGAAAAAAGAAGCTTATTAA

original cDNA sequence snippet

CAATATGGAACTTGAAAAGCGTGAAAAAAGAAGCTTATTAA

altered cDNA sequence snippet

CAATATGGAACTTGAAAAGCATGAAAAAAGAAGCTTATTAA

wildtype AA sequence

MELEKREKRS LLNKNLEEKL TVSAGGSEAK PLIFTFVPTV RRLPTHTQLA DTSKFLVKIP
EESSDKSPET VNRSKSNDYL TLNAGSQQER DQAKLTCPSE VSGTILQERE FEANKLQGMQ
QSDLFKAEYV LIVDSEGEDE AASRKVEQGP PGGIGTAAVR PKSLAISSSL VSDVVRPKTQ
GTDLKTSSHP EMLHGMAPQQ KHGQLTSSPT TSEQLACKPP AFSFVSPTNP NTPPDPVNLE
GASVLEEFHT RRLDVGGAVV EESATYFQTT AHSTPFSASK GTSSTLLFPH STQLSGSNLP
SSTAADPKPG LTSEVLKKTT LTSHVLSHGE SPRTSSSPPS SSASLKSNSA SYIPVRIVTH
SLSPSPKPFT SSFHGSSSTI CSQMSSSGNL SKSGVKSPVP SRLALLTAIL KSNPSHQRPF
SPASCPTFSL NSPASSTLTL DQKEKQTPPT PKKSLSSCSL RAGSPDQGEL QVSELTQQSF
HLPVFTKSTP LSQAPSLSPT KQASSSLASM NVERTPSPTL KSNTMLSLLQ TSTSSSVGLP
PVPPSSSLSS LKSKQDGDLR GPENPRNIHT YPSTLASSAL SSLSPPINQR ATFSSSEKCF
HPSPALSSLI NRSKRASSQL SGQELNPSAL PSLPVSSADF ASLPNLRSSS LPHANLPTLV
PQLSPSALHP HCGSGTLPSR LGKSESTTPN HRSPVSTPSL PISLTRTEEL ISPCALSMST
GPENKKSKQY KTKSSYKAFA AIPTNTLLLE QKALDEPAKT ESVSKDNTLE PPVELYFPAQ
LRQQTEELCA TIDKVLQDSL SMHSSDSPSR SPKTLLGSDT VKTPTTLPRA AGRETKYANL
SSPSSTVSES QLTKPGVIRP VPVKSRILLK KEEEVYEPNP FSKYLEDNSD LFSEQAAHSV
DSYCNGSDTS GPWLL*

mutated AA sequence

MELEKHEKRS LLNKNLEEKL TVSAGGSEAK PLIFTFVPTV RRLPTHTQLA DTSKFLVKIP
EESSDKSPET VNRSKSNDYL TLNAGSQQER DQAKLTCPSE VSGTILQERE FEANKLQGMQ
QSDLFKAEYV LIVDSEGEDE AASRKVEQGP PGGIGTAAVR PKSLAISSSL VSDVVRPKTQ
GTDLKTSSHP EMLHGMAPQQ KHGQLTSSPT TSEQLACKPP AFSFVSPTNP NTPPDPVNLE
GASVLEEFHT RRLDVGGAVV EESATYFQTT AHSTPFSASK GTSSTLLFPH STQLSGSNLP
SSTAADPKPG LTSEVLKKTT LTSHVLSHGE SPRTSSSPPS SSASLKSNSA SYIPVRIVTH
SLSPSPKPFT SSFHGSSSTI CSQMSSSGNL SKSGVKSPVP SRLALLTAIL KSNPSHQRPF
SPASCPTFSL NSPASSTLTL DQKEKQTPPT PKKSLSSCSL RAGSPDQGEL QVSELTQQSF
HLPVFTKSTP LSQAPSLSPT KQASSSLASM NVERTPSPTL KSNTMLSLLQ TSTSSSVGLP
PVPPSSSLSS LKSKQDGDLR GPENPRNIHT YPSTLASSAL SSLSPPINQR ATFSSSEKCF
HPSPALSSLI NRSKRASSQL SGQELNPSAL PSLPVSSADF ASLPNLRSSS LPHANLPTLV
PQLSPSALHP HCGSGTLPSR LGKSESTTPN HRSPVSTPSL PISLTRTEEL ISPCALSMST
GPENKKSKQY KTKSSYKAFA AIPTNTLLLE QKALDEPAKT ESVSKDNTLE PPVELYFPAQ
LRQQTEELCA TIDKVLQDSL SMHSSDSPSR SPKTLLGSDT VKTPTTLPRA AGRETKYANL
SSPSSTVSES QLTKPGVIRP VPVKSRILLK KEEEVYEPNP FSKYLEDNSD LFSEQAAHSV
DSYCNGSDTS GPWLL*

speed

0.82 s

MutationTaster - study a chromosomal position

Results

Taster files

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

Problems