Yum, tasty mutations...

MutationTaster - study a chromosomal position

 MTQE documentation
NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 9 transcript(s)...
Querying Taster for transcript #1: ENST00000221204
Querying Taster for transcript #2: ENST00000398056
Querying Taster for transcript #3: ENST00000521427
Querying Taster for transcript #4: ENST00000522444
Querying Taster for transcript #5: ENST00000518650
Querying Taster for transcript #6: ENST00000381841
Querying Taster for transcript #7: ENST00000427924
Querying Taster for transcript #8: ENST00000398054
Querying Taster for transcript #9: ENST00000381840
MT speed 0 s - this script 6.858526 s

Results

genesymbolpredictionprobabilitymodelprediction
problem		splicingClinVaramino acid changesvariant typedbSNP IDprotein lengthfile
FGL1polymorphism_automatic2.46065945397334e-10simple_aaeI42Vsingle base exchangers3739406show file
FGL1polymorphism_automatic7.41757988365066e-10simple_aaeI72Vsingle base exchangers3739406show file
FGL1polymorphism_automatic7.41757988365066e-10simple_aaeI72Vsingle base exchangers3739406show file
FGL1polymorphism_automatic7.41757988365066e-10simple_aaeI72Vsingle base exchangers3739406show file
FGL1polymorphism_automatic7.41757988365066e-10simple_aaeI72Vsingle base exchangers3739406show file
FGL1polymorphism_automatic7.41757988365066e-10simple_aaeI72Vsingle base exchangers3739406show file
FGL1polymorphism_automatic7.41757988365066e-10simple_aaeI72Vsingle base exchangers3739406show file
FGL1polymorphism_automatic7.41757988365066e-10simple_aaeI72Vsingle base exchangers3739406show file
FGL1polymorphism_automatic7.41757988365066e-10simple_aaeI72Vsingle base exchangers3739406show file

Taster files

Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999753934 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
  • protein features (might be) affected
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000521427
Genbank transcript ID N/A
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.124A>G
cDNA.781A>G
g.28337A>G
AA changes I42V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 42
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      42QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    42QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  72KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73QYRDRGDENSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73QLMDRGDENRVINLAEKRVYADC
protein features
start (aa)end (aa)featuredetails 
2361COILEDPotential.lost
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 849 / 849
position (AA) of stopcodon in wt / mu AA sequence 283 / 283
position of stopcodon in wt / mu cDNA 1506 / 1506
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 658 / 658
chromosome 8
strand -1
last intron/exon boundary 1347
theoretical NMD boundary in CDS 639
length of CDS 849
coding sequence (CDS) position 124
cDNA position
(for ins/del: last normal base / first normal base)		 781
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MRLRAQVRLL ETRVKQQQVK IKQLLQENEV QFLDKGDENT VIDLGSKRQY ADCSEIFNDG
YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK
HGEYWLGNKN LHFLTTQEDY TLKIDLADFE KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT
AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD HDNYEGNCAE EDQSGWWFNR CHSANLNGVY
YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM KIRPNDFIPN VI*
mutated AA sequence MRLRAQVRLL ETRVKQQQVK IKQLLQENEV QFLDKGDENT VVDLGSKRQY ADCSEIFNDG
YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK
HGEYWLGNKN LHFLTTQEDY TLKIDLADFE KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT
AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD HDNYEGNCAE EDQSGWWFNR CHSANLNGVY
YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM KIRPNDFIPN VI*
speed 0.43 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999258242 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000221204
Genbank transcript ID N/A
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.214A>G
cDNA.693A>G
g.28337A>G
AA changes I72V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 72
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      72QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    72QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  70KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73NSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73DENRVINLAEKRVYADC
protein features no protein features affected
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 939 / 939
position (AA) of stopcodon in wt / mu AA sequence 313 / 313
position of stopcodon in wt / mu cDNA 1418 / 1418
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 480 / 480
chromosome 8
strand -1
last intron/exon boundary 1259
theoretical NMD boundary in CDS 729
length of CDS 939
coding sequence (CDS) position 214
cDNA position
(for ins/del: last normal base / first normal base)		 693
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
mutated AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VVDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
speed 1.35 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999258242 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000398056
Genbank transcript ID N/A
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.214A>G
cDNA.1030A>G
g.28337A>G
AA changes I72V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 72
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      72QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    72QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  70KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73NSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73DENRVINLAEKRVYADC
protein features no protein features affected
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 939 / 939
position (AA) of stopcodon in wt / mu AA sequence 313 / 313
position of stopcodon in wt / mu cDNA 1755 / 1755
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 817 / 817
chromosome 8
strand -1
last intron/exon boundary 1596
theoretical NMD boundary in CDS 729
length of CDS 939
coding sequence (CDS) position 214
cDNA position
(for ins/del: last normal base / first normal base)		 1030
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
mutated AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VVDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
speed 1.39 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999258242 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000522444
Genbank transcript ID N/A
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.214A>G
cDNA.439A>G
g.28337A>G
AA changes I72V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 72
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      72QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    72QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  70KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73NSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73DENRVINLAEKRVYADC
protein features no protein features affected
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 939 / 939
position (AA) of stopcodon in wt / mu AA sequence 313 / 313
position of stopcodon in wt / mu cDNA 1164 / 1164
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 226 / 226
chromosome 8
strand -1
last intron/exon boundary 1005
theoretical NMD boundary in CDS 729
length of CDS 939
coding sequence (CDS) position 214
cDNA position
(for ins/del: last normal base / first normal base)		 439
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
mutated AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VVDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
speed 1.38 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999258242 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000518650
Genbank transcript ID N/A
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.214A>G
cDNA.360A>G
g.28337A>G
AA changes I72V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 72
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      72QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    72QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  70KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73NSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73DENRVINLAEKRVYADC
protein features no protein features affected
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 939 / 939
position (AA) of stopcodon in wt / mu AA sequence 313 / 313
position of stopcodon in wt / mu cDNA 1085 / 1085
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 147 / 147
chromosome 8
strand -1
last intron/exon boundary 926
theoretical NMD boundary in CDS 729
length of CDS 939
coding sequence (CDS) position 214
cDNA position
(for ins/del: last normal base / first normal base)		 360
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
mutated AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VVDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
speed 0.81 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999258242 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000427924
Genbank transcript ID NM_004467
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.214A>G
cDNA.323A>G
g.28337A>G
AA changes I72V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 72
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      72QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    72QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  70KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73NSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73DENRVINLAEKRVYADC
protein features no protein features affected
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 939 / 939
position (AA) of stopcodon in wt / mu AA sequence 313 / 313
position of stopcodon in wt / mu cDNA 1048 / 1048
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 110 / 110
chromosome 8
strand -1
last intron/exon boundary 889
theoretical NMD boundary in CDS 729
length of CDS 939
coding sequence (CDS) position 214
cDNA position
(for ins/del: last normal base / first normal base)		 323
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
mutated AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VVDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
speed 0.43 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999258242 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000381841
Genbank transcript ID NM_201552
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.214A>G
cDNA.450A>G
g.28337A>G
AA changes I72V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 72
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      72QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    72QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  70KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73NSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73DENRVINLAEKRVYADC
protein features no protein features affected
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 939 / 939
position (AA) of stopcodon in wt / mu AA sequence 313 / 313
position of stopcodon in wt / mu cDNA 1175 / 1175
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 237 / 237
chromosome 8
strand -1
last intron/exon boundary 1016
theoretical NMD boundary in CDS 729
length of CDS 939
coding sequence (CDS) position 214
cDNA position
(for ins/del: last normal base / first normal base)		 450
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
mutated AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VVDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
speed 0.44 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999258242 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000398054
Genbank transcript ID NM_201553
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.214A>G
cDNA.538A>G
g.28337A>G
AA changes I72V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 72
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      72QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    72QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  70KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73NSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73DENRVINLAEKRVYADC
protein features no protein features affected
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 939 / 939
position (AA) of stopcodon in wt / mu AA sequence 313 / 313
position of stopcodon in wt / mu cDNA 1263 / 1263
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 325 / 325
chromosome 8
strand -1
last intron/exon boundary 1104
theoretical NMD boundary in CDS 729
length of CDS 939
coding sequence (CDS) position 214
cDNA position
(for ins/del: last normal base / first normal base)		 538
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
mutated AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VVDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
speed 0.44 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999258242 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr8:17739538T>CN/A show variant in all transcripts   IGV
HGNC symbol FGL1
Ensembl transcript ID ENST00000381840
Genbank transcript ID NM_147203
UniProt peptide Q08830
alteration type single base exchange
alteration region CDS
DNA changes c.214A>G
cDNA.411A>G
g.28337A>G
AA changes I72V Score: 29 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 72
frameshift no
known variant Reference ID: rs3739406
databasehomozygous (C/C)heterozygousallele carriers
1000G50510541559
ExAC20309-785112458
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)1.3790.049
-0.0660.016
(flanking)0.5860.017
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites no abrogation of potential splice sites
distance from splice site 31
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      72QFLDKGDENTVIDLGSKRQYADCS
mutated  all conserved    72QFLDKGDENTVVDLGSKRQYADC
Ptroglodytes  all identical  ENSPTRG00000020025  72QFLDKGDENTVIDLGSKRQYADC
Mmulatta  no alignment  ENSMMUG00000008862  n/a
Fcatus  not conserved  ENSFCAG00000000427  70KFVHKGEENVVHDRRGKR
Mmusculus  all identical  ENSMUSG00000031594  74QFLDKGSENSFIDLGGKKQYADC
Ggallus  all identical  ENSGALG00000013606  73NSVIDLGGKRQYSDC
Trubripes  no homologue    
Drerio  not conserved  ENSDARG00000087772  26SFYDTGDT----------QYMDC
Dmelanogaster  no homologue    
Celegans  no homologue    
Xtropicalis  all identical  ENSXETG00000000679  73DENRVINLAEKRVYADC
protein features no protein features affected
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 939 / 939
position (AA) of stopcodon in wt / mu AA sequence 313 / 313
position of stopcodon in wt / mu cDNA 1136 / 1136
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 198 / 198
chromosome 8
strand -1
last intron/exon boundary 977
theoretical NMD boundary in CDS 729
length of CDS 939
coding sequence (CDS) position 214
cDNA position
(for ins/del: last normal base / first normal base)		 411
gDNA position
(for ins/del: last normal base / first normal base)		 28337
chromosomal position
(for ins/del: last normal base / first normal base)		 17739538
original gDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered gDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
original cDNA sequence snippet AAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGG
altered cDNA sequence snippet AAGGAGATGAGAATACTGTCGTTGATCTTGGAAGCAAGAGG
wildtype AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
mutated AA sequence MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
QFLDKGDENT VVDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
KIRPNDFIPN VI*
speed 0.79 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

Problems