Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.99999999999961 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
  • protein features (might be) affected
  • splice site changes
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr3:195514403C>TN/A show variant in all transcripts   IGV
HGNC symbol MUC4
Ensembl transcript ID ENST00000463781
Genbank transcript ID NM_018406
UniProt peptide Q99102
alteration type single base exchange
alteration region CDS
DNA changes c.4048G>A
cDNA.4508G>A
g.24746G>A
AA changes A1350T Score: 58 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 1350
frameshift no
known variant Reference ID: rs79754259
databasehomozygous (T/T)heterozygousallele carriers
1000G---
ExAC7345431277
regulatory features H2BK120ac, Histone, Histone 2B Lysine 120 Acetylation
H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
H4K91ac, Histone, Histone 4 Lysine 91 Acetylation
H3K18ac, Histone, Histone 3 Lysine 18 Acetylation
H4K20me3, Histone, Histone 4 Lysine 20 Tri-Methylation
H3K4me1, Histone, Histone 3 Lysine 4 Mono-Methylation
phyloP / phastCons
PhyloPPhastCons
(flanking)0.1020.022
-1.8580.008
(flanking)-0.0110.006
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites
effectgDNA positionscorewt detection sequence exon-intron border
Acc increased24740wt: 0.59 / mu: 0.67wt: ACACCACCCCTCTTCCTGTCACCGACGCTTCCTCAGTATCC
mu: ACACCACCCCTCTTCCTGTCACCGACACTTCCTCAGTATCC		 gtca|CCGA
Donor increased24742wt: 0.34 / mu: 0.94wt: GTCACCGACGCTTCC
mu: GTCACCGACACTTCC		 CACC|gacg
distance from splice site 3966
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      1350TGDTTPLPVTDASSVSTGHTTPLH
mutated  not conserved    1350TGDTTPLPVTDTSSVSTGHTTPL
Ptroglodytes  no homologue    
Mmulatta  no homologue    
Fcatus  no homologue    
Mmusculus  all conserved  ENSMUSG00000079620  1291PGETTTSHAPIMSSSAPSTTH---M
Ggallus  no homologue    
Trubripes  no homologue    
Drerio  no homologue    
Dmelanogaster  no alignment  FBgn0051004  n/a
Celegans  no alignment  K03H1.5  n/a
Xtropicalis  no homologue    
protein features
start (aa)end (aa)featuredetails 
13101425DOMAINAMOP.lost
14381673DOMAINVWFD.might get lost (downstream of altered splice site)
14441445SITECleavage.might get lost (downstream of altered splice site)
14721472CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
15251525CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
15441544CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
15531553CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
15571557CONFLICTV -> A (in Ref. 2; CAB81773/CAC14143/ CAC10061 and 3; AAM66747).might get lost (downstream of altered splice site)
15881588CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
16091609CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
16321632CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
16591659CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
16851685CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
17031703CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
17391739CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
17541754CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
18021802CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
18091809CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
18571857CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
18751914DOMAINEGF-like 1.might get lost (downstream of altered splice site)
18761876CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
18791879DISULFIDBy similarity.might get lost (downstream of altered splice site)
18841884DISULFIDBy similarity.might get lost (downstream of altered splice site)
18901890DISULFIDBy similarity.might get lost (downstream of altered splice site)
19021902DISULFIDBy similarity.might get lost (downstream of altered splice site)
19041904DISULFIDBy similarity.might get lost (downstream of altered splice site)
19131913DISULFIDBy similarity.might get lost (downstream of altered splice site)
19201921CONFLICTMissing (in Ref. 2; CAC14143).might get lost (downstream of altered splice site)
19421942CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
19491949CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
20392039CONFLICTG -> E (in Ref. 1; CAB85604/CAB85605/ CAB85606, 4; CAD22550 and 5; CAB38059).might get lost (downstream of altered splice site)
20492049CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
20782117DOMAINEGF-like 2.might get lost (downstream of altered splice site)
20812081DISULFIDBy similarity.might get lost (downstream of altered splice site)
20862086DISULFIDBy similarity.might get lost (downstream of altered splice site)
20922092DISULFIDBy similarity.might get lost (downstream of altered splice site)
21012101DISULFIDBy similarity.might get lost (downstream of altered splice site)
21032103DISULFIDBy similarity.might get lost (downstream of altered splice site)
21162116DISULFIDBy similarity.might get lost (downstream of altered splice site)
21262146TRANSMEMHelical; (Potential).might get lost (downstream of altered splice site)
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 16239 / 16239
position (AA) of stopcodon in wt / mu AA sequence 5413 / 5413
position of stopcodon in wt / mu cDNA 16699 / 16699
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 461 / 461
chromosome 3
strand -1
last intron/exon boundary 16495
theoretical NMD boundary in CDS 15984
length of CDS 16239
coding sequence (CDS) position 4048
cDNA position
(for ins/del: last normal base / first normal base)		 4508
gDNA position
(for ins/del: last normal base / first normal base)		 24746
chromosomal position
(for ins/del: last normal base / first normal base)		 195514403
original gDNA sequence snippet CCCCTCTTCCTGTCACCGACGCTTCCTCAGTATCCACAGGT
altered gDNA sequence snippet CCCCTCTTCCTGTCACCGACACTTCCTCAGTATCCACAGGT
original cDNA sequence snippet CCCCTCTTCCTGTCACCGACGCTTCCTCAGTATCCACAGGT
altered cDNA sequence snippet CCCCTCTTCCTGTCACCGACACTTCCTCAGTATCCACAGGT
wildtype AA sequence MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA
ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METAPPDEMT
TSFPSSVTNT LMMTSKTITM TTSTDSTLGN TEETSTAGTE SSTPVTSAVS ITAGQEGQSR
TTSWRTSIQD TSASSQNHWT RSTQTTRESQ TSTLTHRTTS TPSFSPSVHN VTGTVSQKTS
PSGETATSSL CSVTNTSMMT SEKITVTTST GSTLGNPGET SSVPVTGSLM PVTSAALVTF
DPEGQSPATF SRTSTQDTTA FSKNHQTQSV ETTRVSQINT LNTLTPVTTS TVLSSPSGFN
PSGTVSQETF PSGETTTSSP SSVSNTFLVT SKVFRMPTSR DSTLGNTEET SLSVSGTISA
ITSKVSTIWW SDTLSTALSP SSLPPKISTA FHTQQSEGAE TTGRPHERSS FSPGVSQEIF
TLHETTTWPS SFSSKGHTTW SQTELPSTST GAATRLVTGN PSTGTAGTIP RVPSKVSAIG
EPGEPTTYSS HSTTLPKTTG AGAQTQWTQE TGTTGEALLS SPSYSVTQMI KTATSPSSSP
MLDRHTSQQI TTAPSTNHST IHSTSTSPQE SPAVSQRGHT QAPQTTQESQ TTRSVSPMTD
TKTVTTPGSS FTASGHSPSE IVPQDAPTIS AATTFAPAPT GDGHTTQAPT TALQAAPSSH
DATLGPSGGT SLSKTGALTL ANSVVSTPGG PEGQWTSASA STSPDTAAAM THTHQAESTE
ASGQTQTSEP ASSGSRTTSA GTATPSSSGA SGTTPSGSEG ISTSGETTRF SSNPSRDSHT
TQSTTELLSA SASHGAIPVS TGMASSIVPG TFHPTLSEAS TAGRPTGQSS PTSPSASPQE
TAAISRMAQT QRTRTSRGSD TISLASQATD TFSTVPPTPP SITSTGLTSP QTETHTLSPS
GSGKTFTTAL ISNATPLPVT YASSASTGHT TPLHVTDASS VSTGHATPLP VTSPSSVSTG
HTTPLPVTDT SSESTGHVTP LPVTSFSSAS TGDSTPLPVT DTSSASTGHV TPLPVTSLSS
ASTGDTTPLP VTDTSSASTG HATSLPVTDT SSVSTGHTTP LPVTDTSSAS TGHATSLPVT
DTSSVSTGHT TPLHVTDASS ASTGQATPLP VTSLSSVSTG DTTPLPVTSP SSASTGHATP
LLVTDTSSAS TGHATPLPVT DASSVSTDHA TSLPVTIPSA ASTGHTTPLP VTDTSSASTG
QATSLLVTDT SSVSTGDTTP LPVTSTSSAS TGHVTPLHVT SPSSASTGHA TPLPVTSLSS
ASTGDTMPLP VTSPSSASTG DTTPLPVTDA SSVSTGHTTP LHVTDASSAS TGQATPLPVT
SLSSVSTGDT TPLPVTSPSS ASTGHATPLL VTDTSSASTG HATPLPVTDA SSVSTDHATS
LPVTIPSAAS TGHTTPLPVT DTSSASTGQA TSLLVTDTSS VSTGDTTPLP VTSTSSASTG
HVTPLHVTSP SSASTGHATP LPVTSLSSAS TGDTMPLPVT SPSSASTGDT TPLPVTDASS
VSTGHTTPLP VTSPSSASTG HTTPLPVTDT SSASKGDTTP LPVTSPSSAS TGHTTPLPVT
DTSSASTGDT TPLPVTNASS LSTGHATPLH VTSPSSASTG HATPLPVTST SSASTGHATP
LPVTGLSSAT TDDTTRLPVT DVSSASTGQA TPLPVTSLSS VSTGDTTPLP VTSPSSASTG
HASPLLVTDA SSASTGQATP LPVTDTSSVS TAHATPLPVT GLSSASTDDT TRLPVTDVSS
ASTGQAIPLP VTSPSSASTG DTTPLPVTDA SSASTGDTTS LPVTIPSSAS SGHTTSLPVT
DASSVSTGHA TSLLVTDASS VSTGDTTPLP VTDTNSASTG DTTPLHVTDA SSVSTGHATS
LPVTSLSSAS TGDTTPLPVT SPSSASSGHT TPLPVTDASS VPTGHATSLP VTDASSVSTG
HATPLPVTDA SSVSTGHATP LPVTDTSSVS TGQATPLPVT SLSSASTGDT TPLPVTDTSS
ASTGQDTPLP VTSLSSVSTG DTTPLPVTNP SSASTGHATP LLVTDASSIS TGHATSLLVT
DASSVSTGHA TALHDTDASS LSTGDTTPLP VTSPSSTSTG DTTPLPVTET SSVSTGHATS
LPVTDTSSAS TGHATSLPVT DTSSASTGHA TPLPVTDTSS ASTGQATPLP VTSPSSASTG
HAIPLLVTDT SSASTGQATP LPVTSLSSAS TGDTTPLPVT DASSVSTGHA TSLPVTSLSS
VSTGDTTPLP VTSPSSASTG HATPLHVTDA SSASTGHATP LPVTSLSSAS TGDTTPLPVT
SPSSASTGHA TPLHVTDASS VSTGDTTPLP VTSSSSASSG HTTPLPVTDA SSASTGDTTP
LPVTDTSSAS TGHATHLPVT GLSSASTGDT TRLPVTNVSS ASTGHATPLP VTSTSSASTG
DTTPLPGTDT SSVSTGHTTP LLVTDASSVS TGDTTRLPVT SPSSASTGHT TPLPVTDTPS
ASTGDTTPLP VTNASSLSTR HATSLHVTSP SSASTGHATS LPVTDTSAAS TGHATPLPVT
STSSASTGDT TPLPVTDTYS ASTGQATPLP VTSLSSVSTG DTTPLPVTSP SSASTGHATP
LLVTDASSAS TGQATPLPVT SLSSVSTGDT TPLPVTSPSS ASTGHATSLP VTDTSSASTG
DTTSLPVTDT SSAYTGDTTS LPVTDTSSSS TGDTTPLLVT ETSSVSTGDT TPLPVTDTSS
ASTGHATPLP VTNTSSVSTG HATPLHVTSP SSASTGHTTP LPVTDASSVS TGHATSLPVT
DASSVFTGHA TSLPVTIPSS ASSGHTTPLP VTDASSVSTG HATSLPVTDA SSVSTGHATP
LPVTDASSVS TGHATPLPLT SLSSVSTGDT TPLPVTDTSS ASTGQATPLP VTSLSSVSTG
DTTPLPVTDT SSASTGHATS LPVTDTSSAS TGHATPLPDT DTSSASTGHA TLLPVTDTSS
ASIGHATSLP VTDTSSISTG HATPLHVTSP SSASTGHATP LPVTDTSSAS TGHANPLHVT
SPSSASTGHA TPLPVTDTSS ASTGHATPLP VTSLSSVSTG DTTPLPVTSP SSASTGHTTP
LPVTDTSSAS TGQATALPVT STSSASTGDT TPLPVTDTSS ASTGQATPLP VTSLSSVSTG
DTTPLPVTSP SSASTGHATP LLVTDASSAS TGQATPLPVT SLSSVSTGDT TPLPVTSPSS
ASTGHATSLP VTDTSSASTG DTTSLPVTDT SSAYTGDTTS LPVTDTSSSS TGDTTPLLVT
ETSSVSTGHA TPLLVTDASS ASTGHATPLH VTSPSSASTG DTTPVPVTDT SSVSTGHATP
LPVTGLSSAS TGDTTRLPVT DISSASTGQA TPLPVTNTSS VSTGDTMPLP VTSPSSASTG
HATPLPVTST SSASTGHATP VPVTSTSSAS TGHTTPLPVT DTSSASTGDT TPLPVTSPSS
ASTGHTTPLH VTIPSSASTG DTSTLPVTGA SSASTGHATP LPVTDTSSVS TGHATPLPVT
SLSSVSTGDT TPLPVTDASS ASTGQATPLP VTSLSSVSTG DTTPLLVTDA SSVSTGHATP
LPVTDTSSAS TGDTTRLPVT DTSSASTGQA TPLPVTSLSS VSTGDTTPLL VTDASSVSTG
HATPLPVTDT SSASTGDTTR LPVTDTSSAS TGQATPLPVT IPSSSSSGHT TPLPVTSTSS
VSTGHVTPLH VTSPSSASTG HVTPLPVTST SSASTGHATP LLVTDASSVS TGHATPLPVT
DASSASTGDT TPLPVTDTSS ASTGQATPLP VTSLSSVSTG DTTPLPVTDA SSASTGHATP
LPVTIPSSVS TGDTMPLPVT SPSSASTGHA TPLPVTGLSS ASTGDTTPLP VTDTSSASTR
HATPLPVTDT SSASTDDTTR LPVTDVSSAS TGHATPLPVT STSSASTGDT TPLPVTDTSS
VSTGHATSLP VTSRSSASTG HATPLPVTDT SSVSTGHATP LPVTSTSSVS TGHATPLPVT
SPSSASTGHA TPVPVTSTSS ASTGDTTPLP VTNASSLSTG HATPLHVTSP SSASRGDTST
LPVTDASSAS TGHATPLPLT SLSSVSTGDT TPLPVTDTSS ASTGQATPLP VTSLSSVSTG
DTTPLPVTIP SSASSGHTTS LPVTDASSVS TGHGTPLPVT STSSASTGDT TPLPVTDTSS
ASTGHATPLP VTDTSSASTG HATPLPVTSL SSVSTGHATP LAVSSATSAS TVSSDSPLKM
ETPGMTTPSL KTDGGRRTAT SPPPTTSQTI ISTIPSTAMH TRSTAAPIPI LPERGVSLFP
YGAGAGDLEF VRRTVDFTSP LFKPATGFPL GSSLRDSLYF TDNGQIIFPE SDYQIFSYPN
PLPTGFTGRD PVALVAPFWD DADFSTGRGT TFYQEYETFY GEHSLLVQQA ESWIRKMTNN
GGYKARWALK VTWVNAHAYP AQWTLGSNTY QAILSTDGSR SYALFLYQSG GMQWDVAQRS
GNPVLMGFSS GDGYFENSPL MSQPVWERYR PDRFLNSNSG LQGLQFYRLH REERPNYRLE
CLQWLKSQPR WPSWGWNQVS CPCSWQQGRR DLRFQPVSIG RWGLGSRQLC SFTSWRGGVC
CSYGPWGEFR EGWHVQRPWQ LAQELEPQSW CCRWNDKPYL CALYQQRRPH VGCATYRPPQ
PAWMFGDPHI TTLDGVSYTF NGLGDFLLVG AQDGNSSFLL QGRTAQTGSA QATNFIAFAA
QYRSSSLGPV TVQWLLEPHD AIRVLLDNQT VTFQPDHEDG GGQETFNATG VLLSRNGSEV
SASFDGWATV SVIALSNILH ASASLPPEYQ NRTEGLLGVW NNNPEDDFRM PNGSTIPPGS
PEEMLFHFGM TWQINGTGLL GKRNDQLPSN FTPVFYSQLQ KNSSWAEHLI SNCDGDSSCI
YDTLALRNAS IGLHTREVSK NYEQANATLN QYPPSINGGR VIEAYKGQTT LIQYTSNAED
ANFTLRDSCT DLELFENGTL LWTPKSLEPF TLEILARSAK IGLASALQPR TVVCHCNAES
QCLYNQTSRV GNSSLEVAGC KCDGGTFGRY CEGSEDACEE PCFPSVHCVP GKGCEACPPN
LTGDGRHCAA LGSSFLCQNQ SCPVNYCYNQ GHCYISQTLG CQPMCTCPPA FTDSRCFLAG
NNFSPTVNLE LPLRVIQLLL SEEENASMAE VNASVAYRLG TLDMRAFLRN SQVERIDSAA
PASGSPIQHW MVISEFQYRP RGPVIDFLNN QLLAAVVEAF LYHVPRRSEE PRNDVVFQPI
SGEDVRDVTA LNVSTLKAYF RCDGYKGYDL VYSPQSGFTC VSPCSRGYCD HGGQCQHLPS
GPRCSCVSFS IYTAWGEHCE HLSMKLDAFF GIFFGALGGL LLLGVGTFVV LRFWGCSGAR
FSYFLNSAEA LP*
mutated AA sequence MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA
ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METAPPDEMT
TSFPSSVTNT LMMTSKTITM TTSTDSTLGN TEETSTAGTE SSTPVTSAVS ITAGQEGQSR
TTSWRTSIQD TSASSQNHWT RSTQTTRESQ TSTLTHRTTS TPSFSPSVHN VTGTVSQKTS
PSGETATSSL CSVTNTSMMT SEKITVTTST GSTLGNPGET SSVPVTGSLM PVTSAALVTF
DPEGQSPATF SRTSTQDTTA FSKNHQTQSV ETTRVSQINT LNTLTPVTTS TVLSSPSGFN
PSGTVSQETF PSGETTTSSP SSVSNTFLVT SKVFRMPTSR DSTLGNTEET SLSVSGTISA
ITSKVSTIWW SDTLSTALSP SSLPPKISTA FHTQQSEGAE TTGRPHERSS FSPGVSQEIF
TLHETTTWPS SFSSKGHTTW SQTELPSTST GAATRLVTGN PSTGTAGTIP RVPSKVSAIG
EPGEPTTYSS HSTTLPKTTG AGAQTQWTQE TGTTGEALLS SPSYSVTQMI KTATSPSSSP
MLDRHTSQQI TTAPSTNHST IHSTSTSPQE SPAVSQRGHT QAPQTTQESQ TTRSVSPMTD
TKTVTTPGSS FTASGHSPSE IVPQDAPTIS AATTFAPAPT GDGHTTQAPT TALQAAPSSH
DATLGPSGGT SLSKTGALTL ANSVVSTPGG PEGQWTSASA STSPDTAAAM THTHQAESTE
ASGQTQTSEP ASSGSRTTSA GTATPSSSGA SGTTPSGSEG ISTSGETTRF SSNPSRDSHT
TQSTTELLSA SASHGAIPVS TGMASSIVPG TFHPTLSEAS TAGRPTGQSS PTSPSASPQE
TAAISRMAQT QRTRTSRGSD TISLASQATD TFSTVPPTPP SITSTGLTSP QTETHTLSPS
GSGKTFTTAL ISNATPLPVT YASSASTGHT TPLHVTDASS VSTGHATPLP VTSPSSVSTG
HTTPLPVTDT SSESTGHVTP LPVTSFSSAS TGDSTPLPVT DTSSASTGHV TPLPVTSLSS
ASTGDTTPLP VTDTSSASTG HATSLPVTDT SSVSTGHTTP LPVTDTSSAS TGHATSLPVT
DTSSVSTGHT TPLHVTDASS ASTGQATPLP VTSLSSVSTG DTTPLPVTSP SSASTGHATP
LLVTDTSSAS TGHATPLPVT DASSVSTDHA TSLPVTIPSA ASTGHTTPLP VTDTSSASTG
QATSLLVTDT SSVSTGDTTP LPVTSTSSAS TGHVTPLHVT SPSSASTGHA TPLPVTSLSS
ASTGDTMPLP VTSPSSASTG DTTPLPVTDT SSVSTGHTTP LHVTDASSAS TGQATPLPVT
SLSSVSTGDT TPLPVTSPSS ASTGHATPLL VTDTSSASTG HATPLPVTDA SSVSTDHATS
LPVTIPSAAS TGHTTPLPVT DTSSASTGQA TSLLVTDTSS VSTGDTTPLP VTSTSSASTG
HVTPLHVTSP SSASTGHATP LPVTSLSSAS TGDTMPLPVT SPSSASTGDT TPLPVTDASS
VSTGHTTPLP VTSPSSASTG HTTPLPVTDT SSASKGDTTP LPVTSPSSAS TGHTTPLPVT
DTSSASTGDT TPLPVTNASS LSTGHATPLH VTSPSSASTG HATPLPVTST SSASTGHATP
LPVTGLSSAT TDDTTRLPVT DVSSASTGQA TPLPVTSLSS VSTGDTTPLP VTSPSSASTG
HASPLLVTDA SSASTGQATP LPVTDTSSVS TAHATPLPVT GLSSASTDDT TRLPVTDVSS
ASTGQAIPLP VTSPSSASTG DTTPLPVTDA SSASTGDTTS LPVTIPSSAS SGHTTSLPVT
DASSVSTGHA TSLLVTDASS VSTGDTTPLP VTDTNSASTG DTTPLHVTDA SSVSTGHATS
LPVTSLSSAS TGDTTPLPVT SPSSASSGHT TPLPVTDASS VPTGHATSLP VTDASSVSTG
HATPLPVTDA SSVSTGHATP LPVTDTSSVS TGQATPLPVT SLSSASTGDT TPLPVTDTSS
ASTGQDTPLP VTSLSSVSTG DTTPLPVTNP SSASTGHATP LLVTDASSIS TGHATSLLVT
DASSVSTGHA TALHDTDASS LSTGDTTPLP VTSPSSTSTG DTTPLPVTET SSVSTGHATS
LPVTDTSSAS TGHATSLPVT DTSSASTGHA TPLPVTDTSS ASTGQATPLP VTSPSSASTG
HAIPLLVTDT SSASTGQATP LPVTSLSSAS TGDTTPLPVT DASSVSTGHA TSLPVTSLSS
VSTGDTTPLP VTSPSSASTG HATPLHVTDA SSASTGHATP LPVTSLSSAS TGDTTPLPVT
SPSSASTGHA TPLHVTDASS VSTGDTTPLP VTSSSSASSG HTTPLPVTDA SSASTGDTTP
LPVTDTSSAS TGHATHLPVT GLSSASTGDT TRLPVTNVSS ASTGHATPLP VTSTSSASTG
DTTPLPGTDT SSVSTGHTTP LLVTDASSVS TGDTTRLPVT SPSSASTGHT TPLPVTDTPS
ASTGDTTPLP VTNASSLSTR HATSLHVTSP SSASTGHATS LPVTDTSAAS TGHATPLPVT
STSSASTGDT TPLPVTDTYS ASTGQATPLP VTSLSSVSTG DTTPLPVTSP SSASTGHATP
LLVTDASSAS TGQATPLPVT SLSSVSTGDT TPLPVTSPSS ASTGHATSLP VTDTSSASTG
DTTSLPVTDT SSAYTGDTTS LPVTDTSSSS TGDTTPLLVT ETSSVSTGDT TPLPVTDTSS
ASTGHATPLP VTNTSSVSTG HATPLHVTSP SSASTGHTTP LPVTDASSVS TGHATSLPVT
DASSVFTGHA TSLPVTIPSS ASSGHTTPLP VTDASSVSTG HATSLPVTDA SSVSTGHATP
LPVTDASSVS TGHATPLPLT SLSSVSTGDT TPLPVTDTSS ASTGQATPLP VTSLSSVSTG
DTTPLPVTDT SSASTGHATS LPVTDTSSAS TGHATPLPDT DTSSASTGHA TLLPVTDTSS
ASIGHATSLP VTDTSSISTG HATPLHVTSP SSASTGHATP LPVTDTSSAS TGHANPLHVT
SPSSASTGHA TPLPVTDTSS ASTGHATPLP VTSLSSVSTG DTTPLPVTSP SSASTGHTTP
LPVTDTSSAS TGQATALPVT STSSASTGDT TPLPVTDTSS ASTGQATPLP VTSLSSVSTG
DTTPLPVTSP SSASTGHATP LLVTDASSAS TGQATPLPVT SLSSVSTGDT TPLPVTSPSS
ASTGHATSLP VTDTSSASTG DTTSLPVTDT SSAYTGDTTS LPVTDTSSSS TGDTTPLLVT
ETSSVSTGHA TPLLVTDASS ASTGHATPLH VTSPSSASTG DTTPVPVTDT SSVSTGHATP
LPVTGLSSAS TGDTTRLPVT DISSASTGQA TPLPVTNTSS VSTGDTMPLP VTSPSSASTG
HATPLPVTST SSASTGHATP VPVTSTSSAS TGHTTPLPVT DTSSASTGDT TPLPVTSPSS
ASTGHTTPLH VTIPSSASTG DTSTLPVTGA SSASTGHATP LPVTDTSSVS TGHATPLPVT
SLSSVSTGDT TPLPVTDASS ASTGQATPLP VTSLSSVSTG DTTPLLVTDA SSVSTGHATP
LPVTDTSSAS TGDTTRLPVT DTSSASTGQA TPLPVTSLSS VSTGDTTPLL VTDASSVSTG
HATPLPVTDT SSASTGDTTR LPVTDTSSAS TGQATPLPVT IPSSSSSGHT TPLPVTSTSS
VSTGHVTPLH VTSPSSASTG HVTPLPVTST SSASTGHATP LLVTDASSVS TGHATPLPVT
DASSASTGDT TPLPVTDTSS ASTGQATPLP VTSLSSVSTG DTTPLPVTDA SSASTGHATP
LPVTIPSSVS TGDTMPLPVT SPSSASTGHA TPLPVTGLSS ASTGDTTPLP VTDTSSASTR
HATPLPVTDT SSASTDDTTR LPVTDVSSAS TGHATPLPVT STSSASTGDT TPLPVTDTSS
VSTGHATSLP VTSRSSASTG HATPLPVTDT SSVSTGHATP LPVTSTSSVS TGHATPLPVT
SPSSASTGHA TPVPVTSTSS ASTGDTTPLP VTNASSLSTG HATPLHVTSP SSASRGDTST
LPVTDASSAS TGHATPLPLT SLSSVSTGDT TPLPVTDTSS ASTGQATPLP VTSLSSVSTG
DTTPLPVTIP SSASSGHTTS LPVTDASSVS TGHGTPLPVT STSSASTGDT TPLPVTDTSS
ASTGHATPLP VTDTSSASTG HATPLPVTSL SSVSTGHATP LAVSSATSAS TVSSDSPLKM
ETPGMTTPSL KTDGGRRTAT SPPPTTSQTI ISTIPSTAMH TRSTAAPIPI LPERGVSLFP
YGAGAGDLEF VRRTVDFTSP LFKPATGFPL GSSLRDSLYF TDNGQIIFPE SDYQIFSYPN
PLPTGFTGRD PVALVAPFWD DADFSTGRGT TFYQEYETFY GEHSLLVQQA ESWIRKMTNN
GGYKARWALK VTWVNAHAYP AQWTLGSNTY QAILSTDGSR SYALFLYQSG GMQWDVAQRS
GNPVLMGFSS GDGYFENSPL MSQPVWERYR PDRFLNSNSG LQGLQFYRLH REERPNYRLE
CLQWLKSQPR WPSWGWNQVS CPCSWQQGRR DLRFQPVSIG RWGLGSRQLC SFTSWRGGVC
CSYGPWGEFR EGWHVQRPWQ LAQELEPQSW CCRWNDKPYL CALYQQRRPH VGCATYRPPQ
PAWMFGDPHI TTLDGVSYTF NGLGDFLLVG AQDGNSSFLL QGRTAQTGSA QATNFIAFAA
QYRSSSLGPV TVQWLLEPHD AIRVLLDNQT VTFQPDHEDG GGQETFNATG VLLSRNGSEV
SASFDGWATV SVIALSNILH ASASLPPEYQ NRTEGLLGVW NNNPEDDFRM PNGSTIPPGS
PEEMLFHFGM TWQINGTGLL GKRNDQLPSN FTPVFYSQLQ KNSSWAEHLI SNCDGDSSCI
YDTLALRNAS IGLHTREVSK NYEQANATLN QYPPSINGGR VIEAYKGQTT LIQYTSNAED
ANFTLRDSCT DLELFENGTL LWTPKSLEPF TLEILARSAK IGLASALQPR TVVCHCNAES
QCLYNQTSRV GNSSLEVAGC KCDGGTFGRY CEGSEDACEE PCFPSVHCVP GKGCEACPPN
LTGDGRHCAA LGSSFLCQNQ SCPVNYCYNQ GHCYISQTLG CQPMCTCPPA FTDSRCFLAG
NNFSPTVNLE LPLRVIQLLL SEEENASMAE VNASVAYRLG TLDMRAFLRN SQVERIDSAA
PASGSPIQHW MVISEFQYRP RGPVIDFLNN QLLAAVVEAF LYHVPRRSEE PRNDVVFQPI
SGEDVRDVTA LNVSTLKAYF RCDGYKGYDL VYSPQSGFTC VSPCSRGYCD HGGQCQHLPS
GPRCSCVSFS IYTAWGEHCE HLSMKLDAFF GIFFGALGGL LLLGVGTFVV LRFWGCSGAR
FSYFLNSAEA LP*
speed 0.60 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project