mutation t@sting

Prediction

polymorphism

Model: simple_aae, prob: 0.999727159578415 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr8:144996029A>GN/A show variant in all transcripts IGV

HGNC symbol

PLEC

Ensembl transcript ID

ENST00000354958

Genbank transcript ID

NM_201379

UniProt peptide

Q15149

alteration type

single base exchange

alteration region

CDS

DNA changes

c.7894T>C
cDNA.8043T>C
g.54874T>C

AA changes

S2632P Score: 74 explain score(s)

position(s) of altered AA
if AA alteration in CDS

2632

frameshift

known variant

Reference ID: rs7833924

database	homozygous (G/G)	heterozygous	allele carriers
1000G	736	865	1601
ExAC	10289	12189	22478

regulatory features

Promoter Associated, Regulatory Feature, Promoter like regulatory feature
PolII, Polymerase, RNA Polymerase II
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
Gene Associated, Regulatory Feature, Gene associated regulatory feature
H2BK5me1, Histone, Histone 2B Lysine 5 mono-methylation
H4K20me1, Histone, Histone 4 Lysine 20 mono-methylation
DNase1, Open Chromatin, DNase1 Hypersensitive Site

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	5.03	0.983
	0.621	0.98
(flanking)	0.034	0.978

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	54876	wt: 0.7442 / mu: 0.7665 (marginal change - not scored)	wt: GTGTCAGCTCAGAGG mu: GTGCCAGCTCAGAGG	GTCA\|gctc
Donor marginally increased	54865	wt: 0.9267 / mu: 0.9722 (marginal change - not scored)	wt: TGCGGCGGAAGGTGT mu: TGCGGCGGAAGGTGC	CGGC\|ggaa
Donor gained	54878	0.51	mu: GCCAGCTCAGAGGCT	CAGC\|tcag

distance from splice site

535

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

2632

mutated

not conserved

2632

Ptroglodytes

no homologue

Mmulatta

not conserved

ENSMMUG00000000388

2791

Fcatus

not conserved

ENSFCAG00000001046

3113

Mmusculus

not conserved

ENSMUSG00000022565

2799

Ggallus

no homologue

Trubripes

not conserved

ENSTRUG00000003715

2794

Drerio

not conserved

ENSDARG00000021987

2673

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
1469	2756	COILED	Potential.	lost
1471	2755	REGION	Central fibrous rod domain.	lost
2755	2755	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
2756	4684	REGION	Globular 2.	might get lost (downstream of altered splice site)
2814	2814	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
2826	2863	REPEAT	Plectin 1.	might get lost (downstream of altered splice site)
2841	2841	MOD_RES	N6-acetyllysine.	might get lost (downstream of altered splice site)
2864	2901	REPEAT	Plectin 2.	might get lost (downstream of altered splice site)
2902	2939	REPEAT	Plectin 3.	might get lost (downstream of altered splice site)
2940	2977	REPEAT	Plectin 4.	might get lost (downstream of altered splice site)
2981	3015	REPEAT	Plectin 5.	might get lost (downstream of altered splice site)
3027	3027	CONFLICT	K -> E (in Ref. 2; AAB05427/AAB05428).	might get lost (downstream of altered splice site)
3033	3033	MOD_RES	Phosphotyrosine (By similarity).	might get lost (downstream of altered splice site)
3091	3091	MOD_RES	N6-acetyllysine.	might get lost (downstream of altered splice site)
3116	3153	REPEAT	Plectin 6.	might get lost (downstream of altered splice site)
3154	3191	REPEAT	Plectin 7.	might get lost (downstream of altered splice site)
3192	3229	REPEAT	Plectin 8.	might get lost (downstream of altered splice site)
3230	3267	REPEAT	Plectin 9.	might get lost (downstream of altered splice site)
3268	3305	REPEAT	Plectin 10.	might get lost (downstream of altered splice site)
3306	3343	REPEAT	Plectin 11.	might get lost (downstream of altered splice site)
3310	3310	CONFLICT	A -> E (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3361	3361	CONFLICT	L -> F (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3362	3362	MOD_RES	Phosphotyrosine.	might get lost (downstream of altered splice site)
3408	3408	CONFLICT	L -> F (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3420	3420	MOD_RES	N6-acetyllysine.	might get lost (downstream of altered splice site)
3447	3447	CONFLICT	A -> S (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3485	3522	REPEAT	Plectin 12.	might get lost (downstream of altered splice site)
3523	3560	REPEAT	Plectin 13.	might get lost (downstream of altered splice site)
3531	3531	CONFLICT	A -> G (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3561	3598	REPEAT	Plectin 14.	might get lost (downstream of altered splice site)
3580	3580	CONFLICT	S -> R (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3589	3589	CONFLICT	Q -> K (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3596	3596	CONFLICT	Q -> E (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3599	3636	REPEAT	Plectin 15.	might get lost (downstream of altered splice site)
3616	3616	CONFLICT	H -> N (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3640	3674	REPEAT	Plectin 16.	might get lost (downstream of altered splice site)
3686	3686	CONFLICT	A -> V (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3786	3786	CONFLICT	A -> G (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3808	3808	CONFLICT	R -> K (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3816	3816	CONFLICT	A -> G (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3820	3857	REPEAT	Plectin 17.	might get lost (downstream of altered splice site)
3821	3821	CONFLICT	C -> F (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3858	3895	REPEAT	Plectin 18.	might get lost (downstream of altered splice site)
3896	3933	REPEAT	Plectin 19.	might get lost (downstream of altered splice site)
3915	3915	CONFLICT	Q -> K (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
3934	3971	REPEAT	Plectin 20.	might get lost (downstream of altered splice site)
3975	4008	REPEAT	Plectin 21.	might get lost (downstream of altered splice site)
3999	3999	CONFLICT	R -> K (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
4007	4007	CONFLICT	T -> S (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
4030	4030	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
4063	4100	REPEAT	Plectin 22.	might get lost (downstream of altered splice site)
4101	4138	REPEAT	Plectin 23.	might get lost (downstream of altered splice site)
4139	4176	REPEAT	Plectin 24.	might get lost (downstream of altered splice site)
4155	4155	MOD_RES	Phosphotyrosine.	might get lost (downstream of altered splice site)
4177	4214	REPEAT	Plectin 25.	might get lost (downstream of altered splice site)
4218	4252	REPEAT	Plectin 26.	might get lost (downstream of altered splice site)
4250	4300	REGION	Binding to intermediate filaments (By similarity).	might get lost (downstream of altered splice site)
4265	4305	REPEAT	Plectin 27.	might get lost (downstream of altered splice site)
4319	4356	REPEAT	Plectin 28.	might get lost (downstream of altered splice site)
4382	4382	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4384	4384	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4385	4385	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4386	4386	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4389	4389	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4390	4390	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4391	4391	MOD_RES	Phosphoserine (By similarity).	might get lost (downstream of altered splice site)
4392	4392	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4393	4393	MOD_RES	Phosphotyrosine.	might get lost (downstream of altered splice site)
4396	4396	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4400	4400	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4402	4402	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
4408	4445	REPEAT	Plectin 29.	might get lost (downstream of altered splice site)
4411	4411	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
4446	4483	REPEAT	Plectin 30.	might get lost (downstream of altered splice site)
4467	4467	CONFLICT	F -> L (in Ref. 1; CAA91196).	might get lost (downstream of altered splice site)
4484	4521	REPEAT	Plectin 31.	might get lost (downstream of altered splice site)
4522	4559	REPEAT	Plectin 32.	might get lost (downstream of altered splice site)
4539	4539	MOD_RES	Phosphothreonine; by CDK1 (By similarity).	might get lost (downstream of altered splice site)
4560	4597	REPEAT	Plectin 33.	might get lost (downstream of altered splice site)
4611	4611	MOD_RES	Phosphotyrosine.	might get lost (downstream of altered splice site)
4613	4613	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4615	4615	MOD_RES	Phosphotyrosine.	might get lost (downstream of altered splice site)
4618	4618	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4620	4620	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4622	4622	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4623	4623	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
4625	4640	REGION	4 X 4 AA tandem repeats of G-S-R-X.	might get lost (downstream of altered splice site)
4626	4626	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4628	4628	MOD_RES	Phosphothreonine.	might get lost (downstream of altered splice site)
4642	4642	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4658	4658	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
4675	4675	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

13578 / 13578

position (AA) of stopcodon in wt / mu AA sequence

4526 / 4526

position of stopcodon in wt / mu cDNA

13727 / 13727

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

150 / 150

chromosome

strand

-1

last intron/exon boundary

7509

theoretical NMD boundary in CDS

7309

length of CDS

13578

coding sequence (CDS) position

7894

cDNA position
(for ins/del: last normal base / first normal base)

8043

gDNA position
(for ins/del: last normal base / first normal base)

54874

chromosomal position
(for ins/del: last normal base / first normal base)

144996029

original gDNA sequence snippet

ATGGCCTGCGGCGGAAGGTGTCAGCTCAGAGGCTGCAGGAG

altered gDNA sequence snippet

ATGGCCTGCGGCGGAAGGTGCCAGCTCAGAGGCTGCAGGAG

original cDNA sequence snippet

ATGGCCTGCGGCGGAAGGTGTCAGCTCAGAGGCTGCAGGAG

altered cDNA sequence snippet

ATGGCCTGCGGCGGAAGGTGCCAGCTCAGAGGCTGCAGGAG

wildtype AA sequence

MDPSRAIQNE ISSLKDERDR VQKKTFTKWV NKHLIKAQRH ISDLYEDLRD GHNLISLLEV
LSGDSLPREK GRMRFHKLQN VQIALDYLRH RQVKLVNIRN DDIADGNPKL TLGLIWTIIL
HFQISDIQVS GQSEDMTAKE KLLLWSQRMV EGYQGLRCDN FTSSWRDGRL FNAIIHRHKP
LLIDMNKVYR QTNLENLDQA FSVAERDLGV TRLLDPEDVD VPQPDEKSII TYVSSLYDAM
PRVPDVQDGV RANELQLRWQ EYRELVLLLL QWMRHHTAAF EERRFPSSFE EIEILWSQFL
KFKEMELPAK EADKNRSKGI YQSLEGAVQA GQLKVPPGYH PLDVEKEWGK LHVAILEREK
QLRSEFERLE CLQRIVTKLQ MEAGLCEEQL NQADALLQSD VRLLAAGKVP QRAGEVERDL
DKADSMIRLL FNDVQTLKDG RHPQGEQMYR RVYRLHERLV AIRTEYNLRL KAGVAAPATQ
VAQVTLQSVQ RRPELEDSTL RYLQDLLAWV EENQHRVDGA EWGVDLPSVE AQLGSHRGLH
QSIEEFRAKI ERARSDEGQL SPATRGAYRD CLGRLDLQYA KLLNSSKARL RSLESLHSFV
AAATKELMWL NEKEEEEVGF DWSDRNTNMT AKKESYSALM RELELKEKKI KELQNAGDRL
LREDHPARPT VESFQAALQT QWSWMLQLCC CIEAHLKENA AYFQFFSDVR EAEGQLQKLQ
EALRRKYSCD RSATVTRLED LLQDAQDEKE QLNEYKGHLS GLAKRAKAVV QLKPRHPAHP
MRGRLPLLAV CDYKQVEVTV HKGDECQLVG PAQPSHWKVL SSSGSEAAVP SVCFLVPPPN
QEAQEAVTRL EAQHQALVTL WHQLHVDMKS LLAWQSLRRD VQLIRSWSLA TFRTLKPEEQ
RQALHSLELH YQAFLRDSQD AGGFGPEDRL MAEREYGSCS HHYQQLLQSL EQGAQEESRC
QRCISELKDI RLQLEACETR TVHRLRLPLD KEPARECAQR IAEQQKAQAE VEGLGKGVAR
LSAEAEKVLA LPEPSPAAPT LRSELELTLG KLEQVRSLSA IYLEKLKTIS LVIRGTQGAE
EVLRAHEEQL KEAQAVPATL PELEATKASL KKLRAQAEAQ QPTFDALRDE LRGAQEVGER
LQQRHGERDV EVERWRERVA QLLERWQAVL AQTDVRQREL EQLGRQLRYY RESADPLGAW
LQDARRRQEQ IQAMPLADSQ AVREQLRQEQ ALLEEIERHG EKVEECQRFA KQYINAIKDY
ELQLVTYKAQ LEPVASPAKK PKVQSGSESV IQEYVDLRTH YSELTTLTSQ YIKFISETLR
RMEEEERLAE QQRAEERERL AEVEAALEKQ RQLAEAHAQA KAQAEREAKE LQQRMQEEVV
RREEAAVDAQ QQKRSIQEEL QQLRQSSEAE IQAKARQAEA AERSRLRIEE EIRVVRLQLE
ATERQRGGAE GELQALRARA EEAEAQKRQA QEEAERLRRQ VQDESQRKRQ AEVELASRVK
AEAEAAREKQ RALQALEELR LQAEEAERRL RQAEVERARQ VQVALETAQR SAEAELQSKR
ASFAEKTAQL ERSLQEEHVA VAQLREEAER RAQQQAEAER AREEAERELE RWQLKANEAL
RLRLQAEEVA QQKSLAQAEA EKQKEEAERE ARRRGKAEEQ AVRQRELAEQ ELEKQRQLAE
GTAQQRLAAE QELIRLRAET EQGEQQRQLL EEELARLQRE AAAATQKRQE LEAELAKVRA
EMEVLLASKA RAEEESRSTS EKSKQRLEAE AGRFRELAEE AARLRALAEE AKRQRQLAEE
DAARQRAEAE RVLAEKLAAI GEATRLKTEA EIALKEKEAE NERLRRLAED EAFQRRRLEE
QAAQHKADIE ERLAQLRKAS DSELERQKGL VEDTLRQRRQ VEEEILALKA SFEKAAAGKA
ELELELGRIR SNAEDTLRSK EQAELEAARQ RQLAAEEERR RREAEERVQK SLAAEEEAAR
QRKAALEEVE RLKAKVEEAR RLRERAEQES ARQLQLAQEA AQKRLQAEEK AHAFAVQQKE
QELQQTLQQE QSVLDQLRGE AEAARRAAEE AEEARVQAER EAAQSRRQVE EAERLKQSAE
EQAQARAQAQ AAAEKLRKEA EQEAARRAQA EQAALRQKQA ADAEMEKHKK FAEQTLRQKA
QVEQELTTLR LQLEETDHQK NLLDEELQRL KAEATEAARQ RSQVEEELFS VRVQMEELSK
LKARIEAENR ALILRDKDNT QRFLQEEAEK MKQVAEEAAR LSVAAQEAAR LRQLAEEDLA
QQRALAEKML KEKMQAVQEA TRLKAEAELL QQQKELAQEQ ARRLQEDKEQ MAQQLAEETQ
GFQRTLEAER QRQLEMSAEA ERLKLRVAEM SRAQARAEED AQRFRKQAEE IGEKLHRTEL
ATQEKVTLVQ TLEIQRQQSD HDAERLREAI AELEREKEKL QQEAKLLQLK SEEMQTVQQE
QLLQETQALQ QSFLSEKDSL LQRERFIEQE KAKLEQLFQD EVAKAQQLRE EQQRQQQQME
QERQRLVASM EEARRRQHEA EEGVRRKQEE LQQLEQQRRQ QEELLAEENQ RLREQLQLLE
EQHRAALAHS EEVTASQVAA TKTLPNGRDA LDGPAAEAEP EHSFDGLRRK VSAQRLQEAG
ILSAEELQRL AQGHTTVDEL ARREDVRHYL QGRSSIAGLL LKATNEKLSV YAALQRQLLS
PGTALILLEA QAASGFLLDP VRNRRLTVNE AVKEGVVGPE LHHKLLSAER AVTGYKDPYT
GQQISLFQAM QKGLIVREHG IRLLEAQIAT GGVIDPVHSH RVPVDVAYRR GYFDEEMNRV
LADPSDDTKG FFDPNTHENL TYLQLLERCV EDPETGLCLL PLTDKAAKGG ELVYTDSEAR
DVFEKATVSA PFGKFQGKTV TIWEIINSEY FTAEQRRDLL RQFRTGRITV EKIIKIIITV
VEEQEQKGRL CFEGLRSLVP AAELLESRVI DRELYQQLQR GERSVRDVAE VDTVRRALRG
ANVIAGVWLE EAGQKLSIYN ALKKDLLPSD MAVALLEAQA GTGHIIDPAT SARLTVDEAV
RAGLVGPEFH EKLLSAEKAV TGYRDPYTGQ SVSLFQALKK GLIPREQGLR LLDAQLSTGG
IVDPSKSHRV PLDVACARGC LDEETSRALS APRADAKAYS DPSTGEPATY GELQQRCRPD
QLTGLSLLPL SEKAARARQE ELYSELQARE TFEKTPVEVP VGGFKGRTVT VWELISSEYF
TAEQRQELLR QFRTGKVTVE KVIKILITIV EEVETLRQER LSFSGLRAPV PASELLASGV
LSRAQFEQLK DGKTTVKDLS ELGSVRTLLQ GSGCLAGIYL EDTKEKVSIY EAMRRGLLRA
TTAALLLEAQ AATGFLVDPV RNQRLYVHEA VKAGVVGPEL HEQLLSAEKA VTGYRDPYSG
STISLFQAMQ KGLVLRQHGI RLLEAQIATG GIIDPVHSHR VPVDVAYQRG YFSEEMNRVL
ADPSDDTKGF FDPNTHENLT YRQLLERCVE DPETGLRLLP LKGAEKAEVV ETTQVYTEEE
TRRAFEETQI DIPGGGSHGG STMSLWEVMQ SDLIPEEQRA QLMADFQAGR VTKERMIIII
IEIIEKTEII RQQGLASYDY VRRRLTAEDL FEARIISLET YNLLREGTRS LREALEAESA
WCYLYGTGSV AGVYLPGSRQ TLSIYQALKK GLLSAEVARL LLEAQAATGF LLDPVKGERL
TVDEAVRKGL VGPELHDRLL SAERAVTGYR DPYTEQTISL FQAMKKELIP TEEALRLLDA
QLATGGIVDP RLGFHLPLEV AYQRGYLNKD THDQLSEPSE VRSYVDPSTD ERLSYTQLLR
RCRRDDGTGQ LLLPLSDARK LTFRGLRKQI TMEELVRSQV MDEATALQLR EGLTSIEEVT
KNLQKFLEGT SCIAGVFVDA TKERLSVYQA MKKGIIRPGT AFELLEAQAA TGYVIDPIKG
LKLTVEEAVR MGIVGPEFKD KLLSAERAVT GYKDPYSGKL ISLFQAMKKG LILKDHGIRL
LEAQIATGGI IDPEESHRLP VEVAYKRGLF DEEMNEILTD PSDDTKGFFD PNTEENLTYL
QLMERCITDP QTGLCLLPLK EKKRERKTSS KSSVRKRRVV IVDPETGKEM SVYEAYRKGL
IDHQTYLELS EQECEWEEIT ISSSDGVVKS MIIDRRSGRQ YDIDDAIAKN LIDRSALDQY
RAGTLSITEF ADMLSGNAGG FRSRSSSVGS SSSYPISPAV SRTQLASWSD PTEETGPVAG
ILDTETLEKV SITEAMHRNL VDNITGQRLL EAQACTGGII DPSTGERFPV TDAVNKGLVD
KIMVDRINLA QKAFCGFEDP RTKTKMSAAQ ALKKGWLYYE AGQRFLEVQY LTGGLIEPDT
PGRVPLDEAL QRGTVDARTA QKLRDVGAYS KYLTCPKTKL KISYKDALDR SMVEEGTGLR
LLEAAAQSTK GYYSPYSVSG SGSTAGSRTG SRTGSRAGSR RGSFDATGSG FSMTFSSSSY
SSSGYGRRYA SGSSASLGGP ESAVA*

mutated AA sequence

MDPSRAIQNE ISSLKDERDR VQKKTFTKWV NKHLIKAQRH ISDLYEDLRD GHNLISLLEV
LSGDSLPREK GRMRFHKLQN VQIALDYLRH RQVKLVNIRN DDIADGNPKL TLGLIWTIIL
HFQISDIQVS GQSEDMTAKE KLLLWSQRMV EGYQGLRCDN FTSSWRDGRL FNAIIHRHKP
LLIDMNKVYR QTNLENLDQA FSVAERDLGV TRLLDPEDVD VPQPDEKSII TYVSSLYDAM
PRVPDVQDGV RANELQLRWQ EYRELVLLLL QWMRHHTAAF EERRFPSSFE EIEILWSQFL
KFKEMELPAK EADKNRSKGI YQSLEGAVQA GQLKVPPGYH PLDVEKEWGK LHVAILEREK
QLRSEFERLE CLQRIVTKLQ MEAGLCEEQL NQADALLQSD VRLLAAGKVP QRAGEVERDL
DKADSMIRLL FNDVQTLKDG RHPQGEQMYR RVYRLHERLV AIRTEYNLRL KAGVAAPATQ
VAQVTLQSVQ RRPELEDSTL RYLQDLLAWV EENQHRVDGA EWGVDLPSVE AQLGSHRGLH
QSIEEFRAKI ERARSDEGQL SPATRGAYRD CLGRLDLQYA KLLNSSKARL RSLESLHSFV
AAATKELMWL NEKEEEEVGF DWSDRNTNMT AKKESYSALM RELELKEKKI KELQNAGDRL
LREDHPARPT VESFQAALQT QWSWMLQLCC CIEAHLKENA AYFQFFSDVR EAEGQLQKLQ
EALRRKYSCD RSATVTRLED LLQDAQDEKE QLNEYKGHLS GLAKRAKAVV QLKPRHPAHP
MRGRLPLLAV CDYKQVEVTV HKGDECQLVG PAQPSHWKVL SSSGSEAAVP SVCFLVPPPN
QEAQEAVTRL EAQHQALVTL WHQLHVDMKS LLAWQSLRRD VQLIRSWSLA TFRTLKPEEQ
RQALHSLELH YQAFLRDSQD AGGFGPEDRL MAEREYGSCS HHYQQLLQSL EQGAQEESRC
QRCISELKDI RLQLEACETR TVHRLRLPLD KEPARECAQR IAEQQKAQAE VEGLGKGVAR
LSAEAEKVLA LPEPSPAAPT LRSELELTLG KLEQVRSLSA IYLEKLKTIS LVIRGTQGAE
EVLRAHEEQL KEAQAVPATL PELEATKASL KKLRAQAEAQ QPTFDALRDE LRGAQEVGER
LQQRHGERDV EVERWRERVA QLLERWQAVL AQTDVRQREL EQLGRQLRYY RESADPLGAW
LQDARRRQEQ IQAMPLADSQ AVREQLRQEQ ALLEEIERHG EKVEECQRFA KQYINAIKDY
ELQLVTYKAQ LEPVASPAKK PKVQSGSESV IQEYVDLRTH YSELTTLTSQ YIKFISETLR
RMEEEERLAE QQRAEERERL AEVEAALEKQ RQLAEAHAQA KAQAEREAKE LQQRMQEEVV
RREEAAVDAQ QQKRSIQEEL QQLRQSSEAE IQAKARQAEA AERSRLRIEE EIRVVRLQLE
ATERQRGGAE GELQALRARA EEAEAQKRQA QEEAERLRRQ VQDESQRKRQ AEVELASRVK
AEAEAAREKQ RALQALEELR LQAEEAERRL RQAEVERARQ VQVALETAQR SAEAELQSKR
ASFAEKTAQL ERSLQEEHVA VAQLREEAER RAQQQAEAER AREEAERELE RWQLKANEAL
RLRLQAEEVA QQKSLAQAEA EKQKEEAERE ARRRGKAEEQ AVRQRELAEQ ELEKQRQLAE
GTAQQRLAAE QELIRLRAET EQGEQQRQLL EEELARLQRE AAAATQKRQE LEAELAKVRA
EMEVLLASKA RAEEESRSTS EKSKQRLEAE AGRFRELAEE AARLRALAEE AKRQRQLAEE
DAARQRAEAE RVLAEKLAAI GEATRLKTEA EIALKEKEAE NERLRRLAED EAFQRRRLEE
QAAQHKADIE ERLAQLRKAS DSELERQKGL VEDTLRQRRQ VEEEILALKA SFEKAAAGKA
ELELELGRIR SNAEDTLRSK EQAELEAARQ RQLAAEEERR RREAEERVQK SLAAEEEAAR
QRKAALEEVE RLKAKVEEAR RLRERAEQES ARQLQLAQEA AQKRLQAEEK AHAFAVQQKE
QELQQTLQQE QSVLDQLRGE AEAARRAAEE AEEARVQAER EAAQSRRQVE EAERLKQSAE
EQAQARAQAQ AAAEKLRKEA EQEAARRAQA EQAALRQKQA ADAEMEKHKK FAEQTLRQKA
QVEQELTTLR LQLEETDHQK NLLDEELQRL KAEATEAARQ RSQVEEELFS VRVQMEELSK
LKARIEAENR ALILRDKDNT QRFLQEEAEK MKQVAEEAAR LSVAAQEAAR LRQLAEEDLA
QQRALAEKML KEKMQAVQEA TRLKAEAELL QQQKELAQEQ ARRLQEDKEQ MAQQLAEETQ
GFQRTLEAER QRQLEMSAEA ERLKLRVAEM SRAQARAEED AQRFRKQAEE IGEKLHRTEL
ATQEKVTLVQ TLEIQRQQSD HDAERLREAI AELEREKEKL QQEAKLLQLK SEEMQTVQQE
QLLQETQALQ QSFLSEKDSL LQRERFIEQE KAKLEQLFQD EVAKAQQLRE EQQRQQQQME
QERQRLVASM EEARRRQHEA EEGVRRKQEE LQQLEQQRRQ QEELLAEENQ RLREQLQLLE
EQHRAALAHS EEVTASQVAA TKTLPNGRDA LDGPAAEAEP EHSFDGLRRK VPAQRLQEAG
ILSAEELQRL AQGHTTVDEL ARREDVRHYL QGRSSIAGLL LKATNEKLSV YAALQRQLLS
PGTALILLEA QAASGFLLDP VRNRRLTVNE AVKEGVVGPE LHHKLLSAER AVTGYKDPYT
GQQISLFQAM QKGLIVREHG IRLLEAQIAT GGVIDPVHSH RVPVDVAYRR GYFDEEMNRV
LADPSDDTKG FFDPNTHENL TYLQLLERCV EDPETGLCLL PLTDKAAKGG ELVYTDSEAR
DVFEKATVSA PFGKFQGKTV TIWEIINSEY FTAEQRRDLL RQFRTGRITV EKIIKIIITV
VEEQEQKGRL CFEGLRSLVP AAELLESRVI DRELYQQLQR GERSVRDVAE VDTVRRALRG
ANVIAGVWLE EAGQKLSIYN ALKKDLLPSD MAVALLEAQA GTGHIIDPAT SARLTVDEAV
RAGLVGPEFH EKLLSAEKAV TGYRDPYTGQ SVSLFQALKK GLIPREQGLR LLDAQLSTGG
IVDPSKSHRV PLDVACARGC LDEETSRALS APRADAKAYS DPSTGEPATY GELQQRCRPD
QLTGLSLLPL SEKAARARQE ELYSELQARE TFEKTPVEVP VGGFKGRTVT VWELISSEYF
TAEQRQELLR QFRTGKVTVE KVIKILITIV EEVETLRQER LSFSGLRAPV PASELLASGV
LSRAQFEQLK DGKTTVKDLS ELGSVRTLLQ GSGCLAGIYL EDTKEKVSIY EAMRRGLLRA
TTAALLLEAQ AATGFLVDPV RNQRLYVHEA VKAGVVGPEL HEQLLSAEKA VTGYRDPYSG
STISLFQAMQ KGLVLRQHGI RLLEAQIATG GIIDPVHSHR VPVDVAYQRG YFSEEMNRVL
ADPSDDTKGF FDPNTHENLT YRQLLERCVE DPETGLRLLP LKGAEKAEVV ETTQVYTEEE
TRRAFEETQI DIPGGGSHGG STMSLWEVMQ SDLIPEEQRA QLMADFQAGR VTKERMIIII
IEIIEKTEII RQQGLASYDY VRRRLTAEDL FEARIISLET YNLLREGTRS LREALEAESA
WCYLYGTGSV AGVYLPGSRQ TLSIYQALKK GLLSAEVARL LLEAQAATGF LLDPVKGERL
TVDEAVRKGL VGPELHDRLL SAERAVTGYR DPYTEQTISL FQAMKKELIP TEEALRLLDA
QLATGGIVDP RLGFHLPLEV AYQRGYLNKD THDQLSEPSE VRSYVDPSTD ERLSYTQLLR
RCRRDDGTGQ LLLPLSDARK LTFRGLRKQI TMEELVRSQV MDEATALQLR EGLTSIEEVT
KNLQKFLEGT SCIAGVFVDA TKERLSVYQA MKKGIIRPGT AFELLEAQAA TGYVIDPIKG
LKLTVEEAVR MGIVGPEFKD KLLSAERAVT GYKDPYSGKL ISLFQAMKKG LILKDHGIRL
LEAQIATGGI IDPEESHRLP VEVAYKRGLF DEEMNEILTD PSDDTKGFFD PNTEENLTYL
QLMERCITDP QTGLCLLPLK EKKRERKTSS KSSVRKRRVV IVDPETGKEM SVYEAYRKGL
IDHQTYLELS EQECEWEEIT ISSSDGVVKS MIIDRRSGRQ YDIDDAIAKN LIDRSALDQY
RAGTLSITEF ADMLSGNAGG FRSRSSSVGS SSSYPISPAV SRTQLASWSD PTEETGPVAG
ILDTETLEKV SITEAMHRNL VDNITGQRLL EAQACTGGII DPSTGERFPV TDAVNKGLVD
KIMVDRINLA QKAFCGFEDP RTKTKMSAAQ ALKKGWLYYE AGQRFLEVQY LTGGLIEPDT
PGRVPLDEAL QRGTVDARTA QKLRDVGAYS KYLTCPKTKL KISYKDALDR SMVEEGTGLR
LLEAAAQSTK GYYSPYSVSG SGSTAGSRTG SRTGSRAGSR RGSFDATGSG FSMTFSSSSY
SSSGYGRRYA SGSSASLGGP ESAVA*

speed

0.91 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project