MutationTaster - study a chromosomal position

NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 4 transcript(s)...
Querying Taster for transcript #1: ENST00000296318
Querying Taster for transcript #2: ENST00000320057
Querying Taster for transcript #3: ENST00000463523
Querying Taster for transcript #4: ENST00000427856
MT speed 0 s - this script 4.532562 s

Results

genesymbol	prediction	probability	model	prediction problem	splicing	ClinVar	amino acid changes	variant type	dbSNP ID	protein length	file
IL17RD	polymorphism_automatic	0.853337925188488	simple_aae				V157M	single base exchange	rs17057718		show file
IL17RD	polymorphism_automatic	0.853337925188488	simple_aae				V157M	single base exchange	rs17057718		show file
IL17RD	polymorphism_automatic	0.960095317836457	simple_aae				V277M	single base exchange	rs17057718		show file
IL17RD	polymorphism_automatic	0.969375655195899	simple_aae				V301M	single base exchange	rs17057718		show file

Taster files

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.146662074811512 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:57136585C>TN/A show variant in all transcripts IGV

HGNC symbol

IL17RD

Ensembl transcript ID

ENST00000320057

Genbank transcript ID

N/A

UniProt peptide

Q8NFM7

alteration type

single base exchange

alteration region

CDS

DNA changes

c.469G>A
cDNA.1012G>A
g.67750G>A

AA changes

V157M Score: 21 explain score(s)

position(s) of altered AA
if AA alteration in CDS

157

frameshift

known variant

Reference ID: rs17057718

database	homozygous (T/T)	heterozygous	allele carriers
1000G	155	721	876
ExAC	2824	18074	20898

regulatory features

H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	4.723	0.979
	2.662	0.971
(flanking)	-1.185	0.287

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	67746	wt: 0.9858 / mu: 0.9983 (marginal change - not scored)	wt: ATCAGAGCCGTGGCC mu: ATCAGAGCCATGGCC	CAGA\|gccg

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

157

mutated

all conserved

157

Ptroglodytes

all identical

ENSPTRG00000015043

259

Mmulatta

all identical

ENSMMUG00000016602

301

Fcatus

not conserved

ENSFCAG00000003575

301

Mmusculus

all identical

ENSMUSG00000040717

301

Ggallus

all conserved

ENSGALG00000005499

303

Trubripes

no homologue

Drerio

all conserved

ENSDARG00000038843

300

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

all conserved

ENSXETG00000000904

300

protein features

start (aa)	end (aa)	feature	details
17	299	TOPO_DOM	Extracellular (Potential).	lost

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

1788 / 1788

position (AA) of stopcodon in wt / mu AA sequence

596 / 596

position of stopcodon in wt / mu cDNA

2331 / 2331

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

544 / 544

chromosome

strand

-1

last intron/exon boundary

2219

theoretical NMD boundary in CDS

1625

length of CDS

1788

coding sequence (CDS) position

469

cDNA position
(for ins/del: last normal base / first normal base)

1012

gDNA position
(for ins/del: last normal base / first normal base)

67750

chromosomal position
(for ins/del: last normal base / first normal base)

57136585

original gDNA sequence snippet

GGGCCGGGCCCATCAGAGCCGTGGCCATCACAGTGCCACTG

altered gDNA sequence snippet

GGGCCGGGCCCATCAGAGCCATGGCCATCACAGTGCCACTG

original cDNA sequence snippet

GGGCCGGGCCCATCAGAGCCGTGGCCATCACAGTGCCACTG

altered cDNA sequence snippet

GGGCCGGGCCCATCAGAGCCATGGCCATCACAGTGCCACTG

wildtype AA sequence

MESQPFLNMK FETDYFVKVV PFPSIKNESN YHPFFFRTRA CDLLLQPDNL ACKPFWKPRN
LNISQHGSDM QVSFDHAPHN FGFRFFYLHY KLKHEGPFKR KTCKQEQTTE TTSCLLQNVS
PGDYIIELVD DTNTTRKVMH YALKPVHSPW AGPIRAVAIT VPLVVISAFA TLFTVMCRKK
QQENIYSHLD EESSESSTYT AALPRERLRP RPKVFLCYSS KDGQNHMNVV QCFAYFLQDF
CGCEVALDLW EDFSLCREGQ REWVIQKIHE SQFIIVVCSK GMKYFVDKKN YKHKGGGRGS
GKGELFLVAV SAIAEKLRQA KQSSSAALSK FIAVYFDYSC EGDVPGILDL STKYRLMDNL
PQLCSHLHSR DHGLQEPGQH TRQGSRRNYF RSKSGRSLYV AICNMHQFID EEPDWFEKQF
VPFHPPPLRY REPVLEKFDS GLVLNDVMCK PGPESDFCLK VEAAVLGATG PADSQHESQH
GGLDQDGEAR PALDGSAALQ PLLHTVKAGS PSDMPRDSGI YDSSVPSSEL SLPLMEGLST
DQTETSSLTE SVSSSSGLGE EEPPALPSKL LSSGSCKADL GCRSYTDELH AVAPL*

mutated AA sequence

MESQPFLNMK FETDYFVKVV PFPSIKNESN YHPFFFRTRA CDLLLQPDNL ACKPFWKPRN
LNISQHGSDM QVSFDHAPHN FGFRFFYLHY KLKHEGPFKR KTCKQEQTTE TTSCLLQNVS
PGDYIIELVD DTNTTRKVMH YALKPVHSPW AGPIRAMAIT VPLVVISAFA TLFTVMCRKK
QQENIYSHLD EESSESSTYT AALPRERLRP RPKVFLCYSS KDGQNHMNVV QCFAYFLQDF
CGCEVALDLW EDFSLCREGQ REWVIQKIHE SQFIIVVCSK GMKYFVDKKN YKHKGGGRGS
GKGELFLVAV SAIAEKLRQA KQSSSAALSK FIAVYFDYSC EGDVPGILDL STKYRLMDNL
PQLCSHLHSR DHGLQEPGQH TRQGSRRNYF RSKSGRSLYV AICNMHQFID EEPDWFEKQF
VPFHPPPLRY REPVLEKFDS GLVLNDVMCK PGPESDFCLK VEAAVLGATG PADSQHESQH
GGLDQDGEAR PALDGSAALQ PLLHTVKAGS PSDMPRDSGI YDSSVPSSEL SLPLMEGLST
DQTETSSLTE SVSSSSGLGE EEPPALPSKL LSSGSCKADL GCRSYTDELH AVAPL*

speed

1.09 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.146662074811512 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:57136585C>TN/A show variant in all transcripts IGV

HGNC symbol

IL17RD

Ensembl transcript ID

ENST00000463523

Genbank transcript ID

N/A

UniProt peptide

Q8NFM7

alteration type

single base exchange

alteration region

CDS

DNA changes

c.469G>A
cDNA.814G>A
g.67750G>A

AA changes

V157M Score: 21 explain score(s)

position(s) of altered AA
if AA alteration in CDS

157

frameshift

known variant

Reference ID: rs17057718

database	homozygous (T/T)	heterozygous	allele carriers
1000G	155	721	876
ExAC	2824	18074	20898

regulatory features

H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	4.723	0.979
	2.662	0.971
(flanking)	-1.185	0.287

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	67746	wt: 0.9858 / mu: 0.9983 (marginal change - not scored)	wt: ATCAGAGCCGTGGCC mu: ATCAGAGCCATGGCC	CAGA\|gccg

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

157

mutated

all conserved

157

Ptroglodytes

all identical

ENSPTRG00000015043

259

Mmulatta

all identical

ENSMMUG00000016602

301

Fcatus

not conserved

ENSFCAG00000003575

301

Mmusculus

all identical

ENSMUSG00000040717

301

Ggallus

all conserved

ENSGALG00000005499

303

Trubripes

no homologue

Drerio

all conserved

ENSDARG00000038843

300

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

all conserved

ENSXETG00000000904

300

protein features

start (aa)	end (aa)	feature	details
17	299	TOPO_DOM	Extracellular (Potential).	lost

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

1788 / 1788

position (AA) of stopcodon in wt / mu AA sequence

596 / 596

position of stopcodon in wt / mu cDNA

2133 / 2133

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

346 / 346

chromosome

strand

-1

last intron/exon boundary

2021

theoretical NMD boundary in CDS

1625

length of CDS

1788

coding sequence (CDS) position

469

cDNA position
(for ins/del: last normal base / first normal base)

814

gDNA position
(for ins/del: last normal base / first normal base)

67750

chromosomal position
(for ins/del: last normal base / first normal base)

57136585

original gDNA sequence snippet

GGGCCGGGCCCATCAGAGCCGTGGCCATCACAGTGCCACTG

altered gDNA sequence snippet

GGGCCGGGCCCATCAGAGCCATGGCCATCACAGTGCCACTG

original cDNA sequence snippet

GGGCCGGGCCCATCAGAGCCGTGGCCATCACAGTGCCACTG

altered cDNA sequence snippet

GGGCCGGGCCCATCAGAGCCATGGCCATCACAGTGCCACTG

wildtype AA sequence

mutated AA sequence

MESQPFLNMK FETDYFVKVV PFPSIKNESN YHPFFFRTRA CDLLLQPDNL ACKPFWKPRN
LNISQHGSDM QVSFDHAPHN FGFRFFYLHY KLKHEGPFKR KTCKQEQTTE TTSCLLQNVS
PGDYIIELVD DTNTTRKVMH YALKPVHSPW AGPIRAMAIT VPLVVISAFA TLFTVMCRKK
QQENIYSHLD EESSESSTYT AALPRERLRP RPKVFLCYSS KDGQNHMNVV QCFAYFLQDF
CGCEVALDLW EDFSLCREGQ REWVIQKIHE SQFIIVVCSK GMKYFVDKKN YKHKGGGRGS
GKGELFLVAV SAIAEKLRQA KQSSSAALSK FIAVYFDYSC EGDVPGILDL STKYRLMDNL
PQLCSHLHSR DHGLQEPGQH TRQGSRRNYF RSKSGRSLYV AICNMHQFID EEPDWFEKQF
VPFHPPPLRY REPVLEKFDS GLVLNDVMCK PGPESDFCLK VEAAVLGATG PADSQHESQH
GGLDQDGEAR PALDGSAALQ PLLHTVKAGS PSDMPRDSGI YDSSVPSSEL SLPLMEGLST
DQTETSSLTE SVSSSSGLGE EEPPALPSKL LSSGSCKADL GCRSYTDELH AVAPL*

speed

0.72 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.0399046821635429 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:57136585C>TN/A show variant in all transcripts IGV

HGNC symbol

IL17RD

Ensembl transcript ID

ENST00000427856

Genbank transcript ID

N/A

UniProt peptide

Q8NFM7

alteration type

single base exchange

alteration region

CDS

DNA changes

c.829G>A
cDNA.829G>A
g.67750G>A

AA changes

V277M Score: 21 explain score(s)

position(s) of altered AA
if AA alteration in CDS

277

frameshift

known variant

Reference ID: rs17057718

database	homozygous (T/T)	heterozygous	allele carriers
1000G	155	721	876
ExAC	2824	18074	20898

regulatory features

H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	4.723	0.979
	2.662	0.971
(flanking)	-1.185	0.287

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	67746	wt: 0.9858 / mu: 0.9983 (marginal change - not scored)	wt: ATCAGAGCCGTGGCC mu: ATCAGAGCCATGGCC	CAGA\|gccg

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

277

mutated

all conserved

277

Ptroglodytes

all identical

ENSPTRG00000015043

259

Mmulatta

all identical

ENSMMUG00000016602

301

Fcatus

no alignment

ENSFCAG00000003575

n/a

Mmusculus

all identical

ENSMUSG00000040717

301

Ggallus

all conserved

ENSGALG00000005499

303

Trubripes

no homologue

Drerio

all conserved

ENSDARG00000038843

300

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

all conserved

ENSXETG00000000904

300

protein features

start (aa)	end (aa)	feature	details
17	299	TOPO_DOM	Extracellular (Potential).	lost
277	277	CARBOHYD	N-linked (GlcNAc...) (Potential).	lost

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

2148 / 2148

position (AA) of stopcodon in wt / mu AA sequence

716 / 716

position of stopcodon in wt / mu cDNA

2148 / 2148

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

1 / 1

chromosome

strand

-1

last intron/exon boundary

2036

theoretical NMD boundary in CDS

1985

length of CDS

2148

coding sequence (CDS) position

829

cDNA position
(for ins/del: last normal base / first normal base)

829

gDNA position
(for ins/del: last normal base / first normal base)

67750

chromosomal position
(for ins/del: last normal base / first normal base)

57136585

original gDNA sequence snippet

GGGCCGGGCCCATCAGAGCCGTGGCCATCACAGTGCCACTG

altered gDNA sequence snippet

GGGCCGGGCCCATCAGAGCCATGGCCATCACAGTGCCACTG

original cDNA sequence snippet

GGGCCGGGCCCATCAGAGCCGTGGCCATCACAGTGCCACTG

altered cDNA sequence snippet

GGGCCGGGCCCATCAGAGCCATGGCCATCACAGTGCCACTG

wildtype AA sequence

MPRASASGVP ALFVSGEQGV GPASRNSGLY NITFKYDNCT TYLNPVGKHV IADAQNITIS
QYACHDQVAV TILWSPGALG IEFLKGFRVI LEELKSEGRQ CQQLILKDPK QLNSSFKRTG
MESQPFLNMK FETDYFVKVV PFPSIKNESN YHPFFFRTRA CDLLLQPDNL ACKPFWKPRN
LNISQHGSDM QVSFDHAPHN FGFRFFYLHY KLKHEGPFKR KTCKQEQTTE TTSCLLQNVS
PGDYIIELVD DTNTTRKVMH YALKPVHSPW AGPIRAVAIT VPLVVISAFA TLFTVMCRKK
QQENIYSHLD EESSESSTYT AALPRERLRP RPKVFLCYSS KDGQNHMNVV QCFAYFLQDF
CGCEVALDLW EDFSLCREGQ REWVIQKIHE SQFIIVVCSK GMKYFVDKKN YKHKGGGRGS
GKGELFLVAV SAIAEKLRQA KQSSSAALSK FIAVYFDYSC EGDVPGILDL STKYRLMDNL
PQLCSHLHSR DHGLQEPGQH TRQGSRRNYF RSKSGRSLYV AICNMHQFID EEPDWFEKQF
VPFHPPPLRY REPVLEKFDS GLVLNDVMCK PGPESDFCLK VEAAVLGATG PADSQHESQH
GGLDQDGEAR PALDGSAALQ PLLHTVKAGS PSDMPRDSGI YDSSVPSSEL SLPLMEGLST
DQTETSSLTE SVSSSSGLGE EEPPALPSKL LSSGSCKADL GCRSYTDELH AVAPL*

mutated AA sequence

MPRASASGVP ALFVSGEQGV GPASRNSGLY NITFKYDNCT TYLNPVGKHV IADAQNITIS
QYACHDQVAV TILWSPGALG IEFLKGFRVI LEELKSEGRQ CQQLILKDPK QLNSSFKRTG
MESQPFLNMK FETDYFVKVV PFPSIKNESN YHPFFFRTRA CDLLLQPDNL ACKPFWKPRN
LNISQHGSDM QVSFDHAPHN FGFRFFYLHY KLKHEGPFKR KTCKQEQTTE TTSCLLQNVS
PGDYIIELVD DTNTTRKVMH YALKPVHSPW AGPIRAMAIT VPLVVISAFA TLFTVMCRKK
QQENIYSHLD EESSESSTYT AALPRERLRP RPKVFLCYSS KDGQNHMNVV QCFAYFLQDF
CGCEVALDLW EDFSLCREGQ REWVIQKIHE SQFIIVVCSK GMKYFVDKKN YKHKGGGRGS
GKGELFLVAV SAIAEKLRQA KQSSSAALSK FIAVYFDYSC EGDVPGILDL STKYRLMDNL
PQLCSHLHSR DHGLQEPGQH TRQGSRRNYF RSKSGRSLYV AICNMHQFID EEPDWFEKQF
VPFHPPPLRY REPVLEKFDS GLVLNDVMCK PGPESDFCLK VEAAVLGATG PADSQHESQH
GGLDQDGEAR PALDGSAALQ PLLHTVKAGS PSDMPRDSGI YDSSVPSSEL SLPLMEGLST
DQTETSSLTE SVSSSSGLGE EEPPALPSKL LSSGSCKADL GCRSYTDELH AVAPL*

speed

0.71 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.0306243448041009 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr3:57136585C>TN/A show variant in all transcripts IGV

HGNC symbol

IL17RD

Ensembl transcript ID

ENST00000296318

Genbank transcript ID

NM_017563

UniProt peptide

Q8NFM7

alteration type

single base exchange

alteration region

CDS

DNA changes

c.901G>A
cDNA.990G>A
g.67750G>A

AA changes

V301M Score: 21 explain score(s)

position(s) of altered AA
if AA alteration in CDS

301

frameshift

known variant

Reference ID: rs17057718

database	homozygous (T/T)	heterozygous	allele carriers
1000G	155	721	876
ExAC	2824	18074	20898

regulatory features

H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	4.723	0.979
	2.662	0.971
(flanking)	-1.185	0.287

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor marginally increased	67746	wt: 0.9858 / mu: 0.9983 (marginal change - not scored)	wt: ATCAGAGCCGTGGCC mu: ATCAGAGCCATGGCC	CAGA\|gccg

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

301

mutated

all conserved

301

Ptroglodytes

all identical

ENSPTRG00000015043

259

Mmulatta

all identical

ENSMMUG00000016602

301

Fcatus

no alignment

ENSFCAG00000003575

n/a

Mmusculus

all identical

ENSMUSG00000040717

301

Ggallus

all conserved

ENSGALG00000005499

303

Trubripes

no homologue

Drerio

all conserved

ENSDARG00000038843

300

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

all conserved

ENSXETG00000000904

300

protein features

start (aa)	end (aa)	feature	details
300	320	TRANSMEM	Helical; (Potential).	lost

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

2220 / 2220

position (AA) of stopcodon in wt / mu AA sequence

740 / 740

position of stopcodon in wt / mu cDNA

2309 / 2309

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

90 / 90

chromosome

strand

-1

last intron/exon boundary

2197

theoretical NMD boundary in CDS

2057

length of CDS

2220

coding sequence (CDS) position

901

cDNA position
(for ins/del: last normal base / first normal base)

990

gDNA position
(for ins/del: last normal base / first normal base)

67750

chromosomal position
(for ins/del: last normal base / first normal base)

57136585

original gDNA sequence snippet

GGGCCGGGCCCATCAGAGCCGTGGCCATCACAGTGCCACTG

altered gDNA sequence snippet

GGGCCGGGCCCATCAGAGCCATGGCCATCACAGTGCCACTG

original cDNA sequence snippet

GGGCCGGGCCCATCAGAGCCGTGGCCATCACAGTGCCACTG

altered cDNA sequence snippet

GGGCCGGGCCCATCAGAGCCATGGCCATCACAGTGCCACTG

wildtype AA sequence

MAPWLQLCSV FFTVNACLNG SQLAVAAGGS GRARGADTCG WRGVGPASRN SGLYNITFKY
DNCTTYLNPV GKHVIADAQN ITISQYACHD QVAVTILWSP GALGIEFLKG FRVILEELKS
EGRQCQQLIL KDPKQLNSSF KRTGMESQPF LNMKFETDYF VKVVPFPSIK NESNYHPFFF
RTRACDLLLQ PDNLACKPFW KPRNLNISQH GSDMQVSFDH APHNFGFRFF YLHYKLKHEG
PFKRKTCKQE QTTETTSCLL QNVSPGDYII ELVDDTNTTR KVMHYALKPV HSPWAGPIRA
VAITVPLVVI SAFATLFTVM CRKKQQENIY SHLDEESSES STYTAALPRE RLRPRPKVFL
CYSSKDGQNH MNVVQCFAYF LQDFCGCEVA LDLWEDFSLC REGQREWVIQ KIHESQFIIV
VCSKGMKYFV DKKNYKHKGG GRGSGKGELF LVAVSAIAEK LRQAKQSSSA ALSKFIAVYF
DYSCEGDVPG ILDLSTKYRL MDNLPQLCSH LHSRDHGLQE PGQHTRQGSR RNYFRSKSGR
SLYVAICNMH QFIDEEPDWF EKQFVPFHPP PLRYREPVLE KFDSGLVLND VMCKPGPESD
FCLKVEAAVL GATGPADSQH ESQHGGLDQD GEARPALDGS AALQPLLHTV KAGSPSDMPR
DSGIYDSSVP SSELSLPLME GLSTDQTETS SLTESVSSSS GLGEEEPPAL PSKLLSSGSC
KADLGCRSYT DELHAVAPL*

mutated AA sequence

MAPWLQLCSV FFTVNACLNG SQLAVAAGGS GRARGADTCG WRGVGPASRN SGLYNITFKY
DNCTTYLNPV GKHVIADAQN ITISQYACHD QVAVTILWSP GALGIEFLKG FRVILEELKS
EGRQCQQLIL KDPKQLNSSF KRTGMESQPF LNMKFETDYF VKVVPFPSIK NESNYHPFFF
RTRACDLLLQ PDNLACKPFW KPRNLNISQH GSDMQVSFDH APHNFGFRFF YLHYKLKHEG
PFKRKTCKQE QTTETTSCLL QNVSPGDYII ELVDDTNTTR KVMHYALKPV HSPWAGPIRA
MAITVPLVVI SAFATLFTVM CRKKQQENIY SHLDEESSES STYTAALPRE RLRPRPKVFL
CYSSKDGQNH MNVVQCFAYF LQDFCGCEVA LDLWEDFSLC REGQREWVIQ KIHESQFIIV
VCSKGMKYFV DKKNYKHKGG GRGSGKGELF LVAVSAIAEK LRQAKQSSSA ALSKFIAVYF
DYSCEGDVPG ILDLSTKYRL MDNLPQLCSH LHSRDHGLQE PGQHTRQGSR RNYFRSKSGR
SLYVAICNMH QFIDEEPDWF EKQFVPFHPP PLRYREPVLE KFDSGLVLND VMCKPGPESD
FCLKVEAAVL GATGPADSQH ESQHGGLDQD GEARPALDGS AALQPLLHTV KAGSPSDMPR
DSGIYDSSVP SSELSLPLME GLSTDQTETS SLTESVSSSS GLGEEEPPAL PSKLLSSGSC
KADLGCRSYT DELHAVAPL*

speed

0.74 s

MutationTaster - study a chromosomal position

Results

Taster files

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

Problems