MutationTaster - study a chromosomal position

NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 3 transcript(s)...
Querying Taster for transcript #1: ENST00000430046
Querying Taster for transcript #2: ENST00000512348
Querying Taster for transcript #3: ENST00000341845
MT speed 0 s - this script 4.523217 s

Results

genesymbol	prediction	probability	model	prediction problem	splicing	ClinVar	amino acid changes	variant type	dbSNP ID	protein length	file
FCHO2	polymorphism_automatic	0.00551111664165604	simple_aae		affected		M371V	single base exchange	rs185435		show file
FCHO2	polymorphism_automatic	0.00551111664165604	simple_aae		affected		M338V	single base exchange	rs185435		show file
FCHO2	polymorphism_automatic	0.00551111664165604	simple_aae		affected		M371V	single base exchange	rs185435		show file

Taster files

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.994488883358344 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr5:72348272A>GN/A show variant in all transcripts IGV

HGNC symbol

FCHO2

Ensembl transcript ID

ENST00000430046

Genbank transcript ID

NM_138782

UniProt peptide

Q0JRZ9

alteration type

single base exchange

alteration region

CDS

DNA changes

c.1111A>G
cDNA.1227A>G
g.96465A>G

AA changes

M371V Score: 21 explain score(s)

position(s) of altered AA
if AA alteration in CDS

371

frameshift

known variant

Reference ID: rs185435

database	homozygous (G/G)	heterozygous	allele carriers
1000G	238	827	1065
ExAC	1916	13983	15899

regulatory features

H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	0.061	0.992
	0.279	0.993
(flanking)	1.54	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor gained	96459	0.30	mu: CACATCACACAGTGG	CATC\|acac
Donor gained	96464	0.88	mu: CACACAGTGGCTTCT	CACA\|gtgg

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

371

mutated

all conserved

371

Ptroglodytes

all conserved

ENSPTRG00000016973

371

Mmulatta

all identical

ENSMMUG00000015422

374

Fcatus

all identical

ENSFCAG00000002158

304

Mmusculus

all identical

ENSMUSG00000041685

371

Ggallus

all identical

ENSGALG00000015019

372

Trubripes

no homologue

Drerio

not conserved

ENSDARG00000035389

389

Dmelanogaster

not conserved

FBgn0037702

729

Celegans

not conserved

F56D12.6

532

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
387	387	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
394	394	MOD_RES	Phosphoserine (By similarity).	might get lost (downstream of altered splice site)
403	403	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
434	519	COMPBIAS	Ser-rich.	might get lost (downstream of altered splice site)
439	439	CONFLICT	S -> P (in Ref. 1; BAF84471).	might get lost (downstream of altered splice site)
462	462	CONFLICT	P -> Q (in Ref. 2; AL831971).	might get lost (downstream of altered splice site)
488	488	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
509	509	MOD_RES	Phosphoserine (By similarity).	might get lost (downstream of altered splice site)
510	510	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
511	511	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
521	810	REGION	Mediates interaction with DAB2, EPS15, EPS15R and ITSN1.	might get lost (downstream of altered splice site)
542	808	DOMAIN	MUHD.	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

2433 / 2433

position (AA) of stopcodon in wt / mu AA sequence

811 / 811

position of stopcodon in wt / mu cDNA

2549 / 2549

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

117 / 117

chromosome

strand

last intron/exon boundary

2527

theoretical NMD boundary in CDS

2360

length of CDS

2433

coding sequence (CDS) position

1111

cDNA position
(for ins/del: last normal base / first normal base)

1227

gDNA position
(for ins/del: last normal base / first normal base)

96465

chromosomal position
(for ins/del: last normal base / first normal base)

72348272

original gDNA sequence snippet

CAAATAACTCACATCACACAATGGCTTCTTTGGATGAATTA

altered gDNA sequence snippet

CAAATAACTCACATCACACAGTGGCTTCTTTGGATGAATTA

original cDNA sequence snippet

CAAATAACTCACATCACACAATGGCTTCTTTGGATGAATTA

altered cDNA sequence snippet

CAAATAACTCACATCACACAGTGGCTTCTTTGGATGAATTA

wildtype AA sequence

MVMAYFVENF WGEKNSGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA
SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA
GTLEAVQTIQ SITQALQKSK ENYNAKCVEQ ERLKKEGATQ REIEKAAVKS KKATDTYKLY
VEKYALAKAD FEQKMTETAQ KFQDIEETHL IHIKEIIGSL SNAIKEIHLQ IGQVHEEFIN
NMANTTVESL IQKFAESKGT GKERPGLIEF EECDTASAVE GIKPRKRKTF ALPGIIKKEK
DAESVECPDA DSLNIPDVDE EGYSIKPETN QNDTKENHFY SSSDSDSEDE EPKKYRIEIK
PMHPNNSHHT MASLDELKVS IGNITLSPAI SRHSPVQMNR NLSNEELTKS KPSAPPNEKG
TSDLLAWDPL FGPSLDSSSS SSLTSSSSAR PTTPLSVGTI VPPPRPASRP KLTSGKLSGI
NEIPRPFSPP VTSNTSPPPA APLARAESSS SISSSASLSA ANTPTVGVSR GPSPVSLGNQ
DTLPVAVALT ESVNAYFKGA DPTKCIVKIT GDMTMSFPSG IIKVFTSNPT PAVLCFRVKN
ISRLEQILPN AQLVFSDPSQ CDSNTKDFWM NMQAVTVYLK KLSEQNPAAS YYNVDVLKYQ
VSSNGIQSTP LNLATYWKCS ASTTDLRVDY KYNPEAMVAP SVLSNIQVVV PVDGGVTNMQ
SLPPAIWNAE QMKAFWKLSS ISEKSENGGS GSLRAKFDLS EGPSKPTTLA VQFLSEGSTL
SGVDFELVGT GYRLSLIKKR FATGRYLADC *

mutated AA sequence

MVMAYFVENF WGEKNSGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA
SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA
GTLEAVQTIQ SITQALQKSK ENYNAKCVEQ ERLKKEGATQ REIEKAAVKS KKATDTYKLY
VEKYALAKAD FEQKMTETAQ KFQDIEETHL IHIKEIIGSL SNAIKEIHLQ IGQVHEEFIN
NMANTTVESL IQKFAESKGT GKERPGLIEF EECDTASAVE GIKPRKRKTF ALPGIIKKEK
DAESVECPDA DSLNIPDVDE EGYSIKPETN QNDTKENHFY SSSDSDSEDE EPKKYRIEIK
PMHPNNSHHT VASLDELKVS IGNITLSPAI SRHSPVQMNR NLSNEELTKS KPSAPPNEKG
TSDLLAWDPL FGPSLDSSSS SSLTSSSSAR PTTPLSVGTI VPPPRPASRP KLTSGKLSGI
NEIPRPFSPP VTSNTSPPPA APLARAESSS SISSSASLSA ANTPTVGVSR GPSPVSLGNQ
DTLPVAVALT ESVNAYFKGA DPTKCIVKIT GDMTMSFPSG IIKVFTSNPT PAVLCFRVKN
ISRLEQILPN AQLVFSDPSQ CDSNTKDFWM NMQAVTVYLK KLSEQNPAAS YYNVDVLKYQ
VSSNGIQSTP LNLATYWKCS ASTTDLRVDY KYNPEAMVAP SVLSNIQVVV PVDGGVTNMQ
SLPPAIWNAE QMKAFWKLSS ISEKSENGGS GSLRAKFDLS EGPSKPTTLA VQFLSEGSTL
SGVDFELVGT GYRLSLIKKR FATGRYLADC *

speed

1.22 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.994488883358344 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr5:72348272A>GN/A show variant in all transcripts IGV

HGNC symbol

FCHO2

Ensembl transcript ID

ENST00000512348

Genbank transcript ID

NM_001146032

UniProt peptide

Q0JRZ9

alteration type

single base exchange

alteration region

CDS

DNA changes

c.1012A>G
cDNA.1040A>G
g.96465A>G

AA changes

M338V Score: 21 explain score(s)

position(s) of altered AA
if AA alteration in CDS

338

frameshift

known variant

Reference ID: rs185435

database	homozygous (G/G)	heterozygous	allele carriers
1000G	238	827	1065
ExAC	1916	13983	15899

regulatory features

H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	0.061	0.992
	0.279	0.993
(flanking)	1.54	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor gained	96459	0.30	mu: CACATCACACAGTGG	CATC\|acac
Donor gained	96464	0.88	mu: CACACAGTGGCTTCT	CACA\|gtgg

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

338

mutated

all conserved

338

Ptroglodytes

all conserved

ENSPTRG00000016973

371

Mmulatta

all identical

ENSMMUG00000015422

374

Fcatus

all identical

ENSFCAG00000002158

304

Mmusculus

all identical

ENSMUSG00000041685

371

Ggallus

all identical

ENSGALG00000015019

372

Trubripes

no homologue

Drerio

not conserved

ENSDARG00000035389

389

Dmelanogaster

not conserved

FBgn0037702

729

Celegans

not conserved

F56D12.6

532

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
387	387	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
394	394	MOD_RES	Phosphoserine (By similarity).	might get lost (downstream of altered splice site)
403	403	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
434	519	COMPBIAS	Ser-rich.	might get lost (downstream of altered splice site)
439	439	CONFLICT	S -> P (in Ref. 1; BAF84471).	might get lost (downstream of altered splice site)
462	462	CONFLICT	P -> Q (in Ref. 2; AL831971).	might get lost (downstream of altered splice site)
488	488	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
509	509	MOD_RES	Phosphoserine (By similarity).	might get lost (downstream of altered splice site)
510	510	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
511	511	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
521	810	REGION	Mediates interaction with DAB2, EPS15, EPS15R and ITSN1.	might get lost (downstream of altered splice site)
542	808	DOMAIN	MUHD.	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

2334 / 2334

position (AA) of stopcodon in wt / mu AA sequence

778 / 778

position of stopcodon in wt / mu cDNA

2362 / 2362

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

29 / 29

chromosome

strand

last intron/exon boundary

2340

theoretical NMD boundary in CDS

2261

length of CDS

2334

coding sequence (CDS) position

1012

cDNA position
(for ins/del: last normal base / first normal base)

1040

gDNA position
(for ins/del: last normal base / first normal base)

96465

chromosomal position
(for ins/del: last normal base / first normal base)

72348272

original gDNA sequence snippet

CAAATAACTCACATCACACAATGGCTTCTTTGGATGAATTA

altered gDNA sequence snippet

CAAATAACTCACATCACACAGTGGCTTCTTTGGATGAATTA

original cDNA sequence snippet

CAAATAACTCACATCACACAATGGCTTCTTTGGATGAATTA

altered cDNA sequence snippet

CAAATAACTCACATCACACAGTGGCTTCTTTGGATGAATTA

wildtype AA sequence

MVMAYFVENF WGEKNSGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA
SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA
GTLEAVQTIQ SITQALQKSK ENYNAKCVEQ ERLKKEGATQ REIEKAAVKS KKATDTYKLY
VEKYALAKAD FEQKMTETAQ VHEEFINNMA NTTVESLIQK FAESKGTGKE RPGLIEFEEC
DTASAVEGIK PRKRKTFALP GIIKKEKDAE SVECPDADSL NIPDVDEEGY SIKPETNQND
TKENHFYSSS DSDSEDEEPK KYRIEIKPMH PNNSHHTMAS LDELKVSIGN ITLSPAISRH
SPVQMNRNLS NEELTKSKPS APPNEKGTSD LLAWDPLFGP SLDSSSSSSL TSSSSARPTT
PLSVGTIVPP PRPASRPKLT SGKLSGINEI PRPFSPPVTS NTSPPPAAPL ARAESSSSIS
SSASLSAANT PTVGVSRGPS PVSLGNQDTL PVAVALTESV NAYFKGADPT KCIVKITGDM
TMSFPSGIIK VFTSNPTPAV LCFRVKNISR LEQILPNAQL VFSDPSQCDS NTKDFWMNMQ
AVTVYLKKLS EQNPAASYYN VDVLKYQVSS NGIQSTPLNL ATYWKCSAST TDLRVDYKYN
PEAMVAPSVL SNIQVVVPVD GGVTNMQSLP PAIWNAEQMK AFWKLSSISE KSENGGSGSL
RAKFDLSEGP SKPTTLAVQF LSEGSTLSGV DFELVGTGYR LSLIKKRFAT GRYLADC*

mutated AA sequence

MVMAYFVENF WGEKNSGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA
SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA
GTLEAVQTIQ SITQALQKSK ENYNAKCVEQ ERLKKEGATQ REIEKAAVKS KKATDTYKLY
VEKYALAKAD FEQKMTETAQ VHEEFINNMA NTTVESLIQK FAESKGTGKE RPGLIEFEEC
DTASAVEGIK PRKRKTFALP GIIKKEKDAE SVECPDADSL NIPDVDEEGY SIKPETNQND
TKENHFYSSS DSDSEDEEPK KYRIEIKPMH PNNSHHTVAS LDELKVSIGN ITLSPAISRH
SPVQMNRNLS NEELTKSKPS APPNEKGTSD LLAWDPLFGP SLDSSSSSSL TSSSSARPTT
PLSVGTIVPP PRPASRPKLT SGKLSGINEI PRPFSPPVTS NTSPPPAAPL ARAESSSSIS
SSASLSAANT PTVGVSRGPS PVSLGNQDTL PVAVALTESV NAYFKGADPT KCIVKITGDM
TMSFPSGIIK VFTSNPTPAV LCFRVKNISR LEQILPNAQL VFSDPSQCDS NTKDFWMNMQ
AVTVYLKKLS EQNPAASYYN VDVLKYQVSS NGIQSTPLNL ATYWKCSAST TDLRVDYKYN
PEAMVAPSVL SNIQVVVPVD GGVTNMQSLP PAIWNAEQMK AFWKLSSISE KSENGGSGSL
RAKFDLSEGP SKPTTLAVQF LSEGSTLSGV DFELVGTGYR LSLIKKRFAT GRYLADC*

speed

1.19 s

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.994488883358344 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr5:72348272A>GN/A show variant in all transcripts IGV

HGNC symbol

FCHO2

Ensembl transcript ID

ENST00000341845

Genbank transcript ID

N/A

UniProt peptide

Q0JRZ9

alteration type

single base exchange

alteration region

CDS

DNA changes

c.1111A>G
cDNA.1227A>G
g.96465A>G

AA changes

M371V Score: 21 explain score(s)

position(s) of altered AA
if AA alteration in CDS

371

frameshift

known variant

Reference ID: rs185435

database	homozygous (G/G)	heterozygous	allele carriers
1000G	238	827	1065
ExAC	1916	13983	15899

regulatory features

H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	0.061	0.992
	0.279	0.993
(flanking)	1.54	1

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Donor gained	96459	0.30	mu: CACATCACACAGTGG	CATC\|acac
Donor gained	96464	0.88	mu: CACACAGTGGCTTCT	CACA\|gtgg

distance from splice site

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

371

mutated

all conserved

371

Ptroglodytes

all conserved

ENSPTRG00000016973

371

Mmulatta

all identical

ENSMMUG00000015422

374

Fcatus

all identical

ENSFCAG00000002158

304

Mmusculus

all identical

ENSMUSG00000041685

371

Ggallus

all identical

ENSGALG00000015019

372

Trubripes

no homologue

Drerio

not conserved

ENSDARG00000035389

389

Dmelanogaster

not conserved

FBgn0037702

729

Celegans

not conserved

F56D12.6

532

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
387	387	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
394	394	MOD_RES	Phosphoserine (By similarity).	might get lost (downstream of altered splice site)
403	403	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
434	519	COMPBIAS	Ser-rich.	might get lost (downstream of altered splice site)
439	439	CONFLICT	S -> P (in Ref. 1; BAF84471).	might get lost (downstream of altered splice site)
462	462	CONFLICT	P -> Q (in Ref. 2; AL831971).	might get lost (downstream of altered splice site)
488	488	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
509	509	MOD_RES	Phosphoserine (By similarity).	might get lost (downstream of altered splice site)
510	510	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
511	511	MOD_RES	Phosphoserine.	might get lost (downstream of altered splice site)
521	810	REGION	Mediates interaction with DAB2, EPS15, EPS15R and ITSN1.	might get lost (downstream of altered splice site)
542	808	DOMAIN	MUHD.	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

2433 / 2433

position (AA) of stopcodon in wt / mu AA sequence

811 / 811

position of stopcodon in wt / mu cDNA

2549 / 2549

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

117 / 117

chromosome

strand

last intron/exon boundary

2527

theoretical NMD boundary in CDS

2360

length of CDS

2433

coding sequence (CDS) position

1111

cDNA position
(for ins/del: last normal base / first normal base)

1227

gDNA position
(for ins/del: last normal base / first normal base)

96465

chromosomal position
(for ins/del: last normal base / first normal base)

72348272

original gDNA sequence snippet

CAAATAACTCACATCACACAATGGCTTCTTTGGATGAATTA

altered gDNA sequence snippet

CAAATAACTCACATCACACAGTGGCTTCTTTGGATGAATTA

original cDNA sequence snippet

CAAATAACTCACATCACACAATGGCTTCTTTGGATGAATTA

altered cDNA sequence snippet

CAAATAACTCACATCACACAGTGGCTTCTTTGGATGAATTA

wildtype AA sequence

MVMAYFVENF WGEKNSGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA
SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA
GTLEAVQTIQ SITQALQKSK ENYNAKCVEQ ERLKKEGATQ REIEKAAVKS KKATDTYKLY
VEKYALAKAD FEQKMTETAQ KFQDIEETHL IHIKEIIGSL SNAIKEIHLQ IGQVHEEFIN
NMANTTVESL IQKFAESKGT GKERPGLIEF EECDTASAVE GIKPRKRKTF ALPGIIKKEK
DAESVECPDA DSLNIPDVDE EGYSIKPETN QNDTKENHFY SSSDSDSEDE EPKKYRIEIK
PMHPNNSHHT MASLDELKVS IGNITLSPAI SVSTNTRLNR NFNDEELTKS KPSAPPNEKG
TSDLLAWDPL FGPSLDSSSS SSLTSSSSAR PTTPLSVGTI VPPPRPASRP KLTSGKLSGI
NEIPRPFSPP VTSNTSPPPA APLARAESSS SISSSASLSA ANTPTVGVSR GPSPVSLGNQ
DTLPVAVALT ESVNAYFKGA DPTKCIVKIT GDMTMSFPSG IIKVFTSNPT PAVLCFRVKN
ISRLEQILPN AQLVFSDPSQ CDSNTKDFWM NMQAVTVYLK KLSEQNPAAS YYNVDVLKYQ
VSSNGIQSTP LNLATYWKCS ASTTDLRVDY KYNPEAMVAP SVLSNIQVVV PVDGGVTNMQ
SLPPAIWNAE QMKAFWKLSS ISEKSENGGS GSLRAKFDLS EGPSKPTTLA VQFLSEGSTL
SGVDFELVGT GYRLSLIKKR FATGRYLADC *

mutated AA sequence

MVMAYFVENF WGEKNSGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA
SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA
GTLEAVQTIQ SITQALQKSK ENYNAKCVEQ ERLKKEGATQ REIEKAAVKS KKATDTYKLY
VEKYALAKAD FEQKMTETAQ KFQDIEETHL IHIKEIIGSL SNAIKEIHLQ IGQVHEEFIN
NMANTTVESL IQKFAESKGT GKERPGLIEF EECDTASAVE GIKPRKRKTF ALPGIIKKEK
DAESVECPDA DSLNIPDVDE EGYSIKPETN QNDTKENHFY SSSDSDSEDE EPKKYRIEIK
PMHPNNSHHT VASLDELKVS IGNITLSPAI SVSTNTRLNR NFNDEELTKS KPSAPPNEKG
TSDLLAWDPL FGPSLDSSSS SSLTSSSSAR PTTPLSVGTI VPPPRPASRP KLTSGKLSGI
NEIPRPFSPP VTSNTSPPPA APLARAESSS SISSSASLSA ANTPTVGVSR GPSPVSLGNQ
DTLPVAVALT ESVNAYFKGA DPTKCIVKIT GDMTMSFPSG IIKVFTSNPT PAVLCFRVKN
ISRLEQILPN AQLVFSDPSQ CDSNTKDFWM NMQAVTVYLK KLSEQNPAAS YYNVDVLKYQ
VSSNGIQSTP LNLATYWKCS ASTTDLRVDY KYNPEAMVAP SVLSNIQVVV PVDGGVTNMQ
SLPPAIWNAE QMKAFWKLSS ISEKSENGGS GSLRAKFDLS EGPSKPTTLA VQFLSEGSTL
SGVDFELVGT GYRLSLIKKR FATGRYLADC *

speed

1.22 s

MutationTaster - study a chromosomal position

Results

Taster files

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

Problems