MutationTaster - study a chromosomal position

NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 2 transcript(s)...
Querying Taster for transcript #1: ENST00000297267
Querying Taster for transcript #2: ENST00000340366
MT speed 1.97 s - this script 4.053915 s

Results

genesymbol	prediction	probability	model	prediction problem	splicing	ClinVar	amino acid changes	variant type	dbSNP ID	protein length	file
FNDC1	polymorphism_automatic	4.05949155890539e-05	simple_aae		affected		D1180E	single base exchange	rs420054		show file
FNDC1	polymorphism_automatic	9.24977664169546e-05	simple_aae		affected		D1117E	single base exchange	rs420054		show file

Taster files

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999959405084411 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:159655084C>GN/A show variant in all transcripts IGV

HGNC symbol

FNDC1

Ensembl transcript ID

ENST00000297267

Genbank transcript ID

NM_032532

UniProt peptide

Q4ZHG4

alteration type

single base exchange

alteration region

CDS

DNA changes

c.3540C>G
cDNA.3740C>G
g.64656C>G

AA changes

D1180E Score: 45 explain score(s)

position(s) of altered AA
if AA alteration in CDS

1180

frameshift

known variant

Reference ID: rs420054

database	homozygous (G/G)	heterozygous	allele carriers
1000G	1577	764	2341
ExAC	-	-	-

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
DNase1, Open Chromatin, DNase1 Hypersensitive Site

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	2.877	0.996
	0.17	0.996
(flanking)	1.944	0.982

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Acc increased	64648	wt: 0.21 / mu: 0.25	wt: CCCAGCAGTCGGTCTCAGCCGAGGACGACGAGGAGGAGGAC mu: CCCAGCAGTCGGTCTCAGCCGAGGACGAGGAGGAGGAGGAC	gccg\|AGGA
Donor gained	64650	0.93	mu: GCCGAGGACGAGGAG	CGAG\|gacg

distance from splice site

428

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

1180

mutated

all conserved

1180

Ptroglodytes

all conserved

ENSPTRG00000018754

1180

Mmulatta

all conserved

ENSMMUG00000000500

1127

Fcatus

no homologue

Mmusculus

not conserved

ENSMUSG00000071984

1023

Ggallus

all identical

ENSGALG00000011663

735

SSS

Trubripes

not conserved

ENSTRUG00000004949

881

Drerio

all identical

ENSDARG00000002847

916

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
1295	1295	CONFLICT	M -> K (in Ref. 6; CAE51894).	might get lost (downstream of altered splice site)
1443	1516	COMPBIAS	Thr-rich.	might get lost (downstream of altered splice site)
1487	1487	CONFLICT	P -> S (in Ref. 6; CAE51894).	might get lost (downstream of altered splice site)
1655	1749	DOMAIN	Fibronectin type-III 5.	might get lost (downstream of altered splice site)
1661	1661	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
1685	1685	CONFLICT	D -> N (in Ref. 6; CAE51894).	might get lost (downstream of altered splice site)
1894	1894	CONFLICT	W -> G (in Ref. 6; CAE51894).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

5685 / 5685

position (AA) of stopcodon in wt / mu AA sequence

1895 / 1895

position of stopcodon in wt / mu cDNA

5885 / 5885

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

201 / 201

chromosome

strand

last intron/exon boundary

5770

theoretical NMD boundary in CDS

5519

length of CDS

5685

coding sequence (CDS) position

3540

cDNA position
(for ins/del: last normal base / first normal base)

3740

gDNA position
(for ins/del: last normal base / first normal base)

64656

chromosomal position
(for ins/del: last normal base / first normal base)

159655084

original gDNA sequence snippet

TCGGTCTCAGCCGAGGACGACGAGGAGGAGGACGCGGGATT

altered gDNA sequence snippet

TCGGTCTCAGCCGAGGACGAGGAGGAGGAGGACGCGGGATT

original cDNA sequence snippet

TCGGTCTCAGCCGAGGACGACGAGGAGGAGGACGCGGGATT

altered cDNA sequence snippet

TCGGTCTCAGCCGAGGACGAGGAGGAGGAGGACGCGGGATT

wildtype AA sequence

MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD
PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS
RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP
RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR
SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR
YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT
TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKEYILSYA PALKPFGAKS LTYPGDTTSA
LVDGLQPGER YLFKIRATNR RGLGPHSKAF IVAMPTTSKA DVEQNTEDNG KPEKPEPSSP
SPRAPASSQH PSVPASPQGR NAKDLLLDLK NKILANGGAP RKPQLRAKKA EELDLQSTEI
TGEEELGSRE DSPMSPSDTQ DQKRTLRPPS RHGHSVVAPG RTAVRARMPA LPRREGVDKP
GFSLATQPRP GAPPSASASP AHHASTQGTS HRPSLPASLN DNDLVDSDED ERAVGSLHPK
GAFAQPRPAL SPSRQSPSSV LRDRSSVHPG AKPASPARRT PHSGAAEEDS SASAPPSRLS
PPHGGSSRLL PTQPHLSSPL SKGGKDGEDA PATNSNAPSR STMSSSVSSH LSSRTQVSEG
AEASDGESHG DGDREDGGRQ AEATAQTLRA RPASGHFHLL RHKPFAANGR SPSRFSIGRG
PRLQPSSSPQ STVPSRAHPR VPSHSDSHPK LSSGIHGDEE DEKPLPATVV NDHVPSSSRQ
PISRGWEDLR RSPQRGASLH RKEPIPENPK STGADTHPQG KYSSLASKAQ DVQQSTDADT
EGHSPKAQPG STDRHASPAR PPAARSQQHP SVPRRMTPGR APQQQPPPPV ATSQHHPGPQ
SRDAGRSPSQ PRLSLTQAGR PRPTSQGRSH SSSDPYTASS RGMLPTALQN QDEDAQGSYD
DDSTEVEAQD VRAPAHAARA KEAAASLPKH QQVESPTGAG AGGDHRSQRG HAASPARPSR
PGGPQSRARV PSRAAPGKSE PPSKRPLSSK SQQSVSAEDD EEEDAGFFKG GKEDLLSSSV
PKWPSSSTPR GGKDADGSLA KEEREPAIAL APRGGSLAPV KRPLPPPPGS SPRASHVPSR
LPPRSAATVS PVAGTHPWPQ YTTRAPPGHF STTPMLSLRQ RMMHARFRNP LSRQPARPSY
RQGYNGRPNV EGKVLPGSNG KPNGQRIING PQGTKWVVDL DRGLVLNAEG RYLQDSHGNP
LRIKLGGDGR TIVDLEGTPV VSPDGLPLFG QGRHGTPLAN AQDKPILSLG GKPLVGLEVI
KKTTHPPTTT MQPTTTTTPL PTTTTPRPTT ATTRRTTTTR RTTTRRPTTT VRTTTRTTTT
TTPTPTTPIP TCPPGTLERH DDDGNLIMSS NGIPECYAEE DEFSGLETDT AVPTEEAYVI
YDEDYEFETS RPPTTTEPST TATTPRVIPE EGAISSFPEE EFDLAGRKRF VAPYVTYLNK
DPSAPCSLTD ALDHFQVDSL DEIIPNDLKK SDLPPQHAPR NITVVAVEGC HSFVIVDWDK
ATPGDVVTGY LVYSASYEDF IRNKWSTQAS SVTHLPIENL KPNTRYYFKV QAQNPHGYGP
ISPSVSFVTE SDNPLLVVRP PGGEPIWIPF AFKHDPSYTD CHGRQYVKRT WYRKFVGVVL
CNSLRYKIYL SDNLKDTFYS IGDSWGRGED HCQFVDSHLD GRTGPQSYVE ALPTIQGYYR
QYRQEPVRFG NIGFGTPYYY VGWYECGVSI PGKW*

mutated AA sequence

MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD
PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS
RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP
RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR
SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR
YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT
TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKEYILSYA PALKPFGAKS LTYPGDTTSA
LVDGLQPGER YLFKIRATNR RGLGPHSKAF IVAMPTTSKA DVEQNTEDNG KPEKPEPSSP
SPRAPASSQH PSVPASPQGR NAKDLLLDLK NKILANGGAP RKPQLRAKKA EELDLQSTEI
TGEEELGSRE DSPMSPSDTQ DQKRTLRPPS RHGHSVVAPG RTAVRARMPA LPRREGVDKP
GFSLATQPRP GAPPSASASP AHHASTQGTS HRPSLPASLN DNDLVDSDED ERAVGSLHPK
GAFAQPRPAL SPSRQSPSSV LRDRSSVHPG AKPASPARRT PHSGAAEEDS SASAPPSRLS
PPHGGSSRLL PTQPHLSSPL SKGGKDGEDA PATNSNAPSR STMSSSVSSH LSSRTQVSEG
AEASDGESHG DGDREDGGRQ AEATAQTLRA RPASGHFHLL RHKPFAANGR SPSRFSIGRG
PRLQPSSSPQ STVPSRAHPR VPSHSDSHPK LSSGIHGDEE DEKPLPATVV NDHVPSSSRQ
PISRGWEDLR RSPQRGASLH RKEPIPENPK STGADTHPQG KYSSLASKAQ DVQQSTDADT
EGHSPKAQPG STDRHASPAR PPAARSQQHP SVPRRMTPGR APQQQPPPPV ATSQHHPGPQ
SRDAGRSPSQ PRLSLTQAGR PRPTSQGRSH SSSDPYTASS RGMLPTALQN QDEDAQGSYD
DDSTEVEAQD VRAPAHAARA KEAAASLPKH QQVESPTGAG AGGDHRSQRG HAASPARPSR
PGGPQSRARV PSRAAPGKSE PPSKRPLSSK SQQSVSAEDE EEEDAGFFKG GKEDLLSSSV
PKWPSSSTPR GGKDADGSLA KEEREPAIAL APRGGSLAPV KRPLPPPPGS SPRASHVPSR
LPPRSAATVS PVAGTHPWPQ YTTRAPPGHF STTPMLSLRQ RMMHARFRNP LSRQPARPSY
RQGYNGRPNV EGKVLPGSNG KPNGQRIING PQGTKWVVDL DRGLVLNAEG RYLQDSHGNP
LRIKLGGDGR TIVDLEGTPV VSPDGLPLFG QGRHGTPLAN AQDKPILSLG GKPLVGLEVI
KKTTHPPTTT MQPTTTTTPL PTTTTPRPTT ATTRRTTTTR RTTTRRPTTT VRTTTRTTTT
TTPTPTTPIP TCPPGTLERH DDDGNLIMSS NGIPECYAEE DEFSGLETDT AVPTEEAYVI
YDEDYEFETS RPPTTTEPST TATTPRVIPE EGAISSFPEE EFDLAGRKRF VAPYVTYLNK
DPSAPCSLTD ALDHFQVDSL DEIIPNDLKK SDLPPQHAPR NITVVAVEGC HSFVIVDWDK
ATPGDVVTGY LVYSASYEDF IRNKWSTQAS SVTHLPIENL KPNTRYYFKV QAQNPHGYGP
ISPSVSFVTE SDNPLLVVRP PGGEPIWIPF AFKHDPSYTD CHGRQYVKRT WYRKFVGVVL
CNSLRYKIYL SDNLKDTFYS IGDSWGRGED HCQFVDSHLD GRTGPQSYVE ALPTIQGYYR
QYRQEPVRFG NIGFGTPYYY VGWYECGVSI PGKW*

speed

1.12 s

All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

mutation t@sting

documentation

Prediction

polymorphism

Model: simple_aae, prob: 0.999907502233583 (classification due to TGP/ExAC, real probability is shown anyway) (explain)

Summary

amino acid sequence changed
homozygous in TGP or ExAC
protein features (might be) affected
splice site changes

hyperlink

analysed issue

analysis result

name of alteration

no title

alteration (phys. location)

chr6:159655084C>GN/A show variant in all transcripts IGV

HGNC symbol

FNDC1

Ensembl transcript ID

ENST00000340366

Genbank transcript ID

N/A

UniProt peptide

Q4ZHG4

alteration type

single base exchange

alteration region

CDS

DNA changes

c.3351C>G
cDNA.3551C>G
g.64656C>G

AA changes

D1117E Score: 45 explain score(s)

position(s) of altered AA
if AA alteration in CDS

1117

frameshift

known variant

Reference ID: rs420054

database	homozygous (G/G)	heterozygous	allele carriers
1000G	1577	764	2341
ExAC	-	-	-

regulatory features

H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
H3K36me3, Histone, Histone 3 Lysine 36 Tri-Methylation
DNase1, Open Chromatin, DNase1 Hypersensitive Site

phyloP / phastCons

	PhyloP	PhastCons
(flanking)	2.877	0.996
	0.17	0.996
(flanking)	1.944	0.982

explain score(s) and/or inspect your position(s) in in UCSC Genome Browser

splice sites

effect	gDNA position	score	wt detection sequence	exon-intron border
Acc increased	64648	wt: 0.21 / mu: 0.25	wt: CCCAGCAGTCGGTCTCAGCCGAGGACGACGAGGAGGAGGAC mu: CCCAGCAGTCGGTCTCAGCCGAGGACGAGGAGGAGGAGGAC	gccg\|AGGA
Donor gained	64650	0.93	mu: GCCGAGGACGAGGAG	CGAG\|gacg

distance from splice site

428

Kozak consensus sequence altered?

N/A

conservation
protein level for non-synonymous changes

species

match

gene

alignment

Human

1117

mutated

all conserved

1117

Ptroglodytes

all conserved

ENSPTRG00000018754

1180

Mmulatta

all conserved

ENSMMUG00000000500

1127

Fcatus

no homologue

Mmusculus

all conserved

ENSMUSG00000071984

1023

Ggallus

all identical

ENSGALG00000011663

735

SSS

Trubripes

all conserved

ENSTRUG00000004949

842

STGNAEKTN

Drerio

all identical

ENSDARG00000002847

916

Dmelanogaster

no homologue

Celegans

no homologue

Xtropicalis

no homologue

protein features

start (aa)	end (aa)	feature	details
1295	1295	CONFLICT	M -> K (in Ref. 6; CAE51894).	might get lost (downstream of altered splice site)
1443	1516	COMPBIAS	Thr-rich.	might get lost (downstream of altered splice site)
1487	1487	CONFLICT	P -> S (in Ref. 6; CAE51894).	might get lost (downstream of altered splice site)
1655	1749	DOMAIN	Fibronectin type-III 5.	might get lost (downstream of altered splice site)
1661	1661	CARBOHYD	N-linked (GlcNAc...) (Potential).	might get lost (downstream of altered splice site)
1685	1685	CONFLICT	D -> N (in Ref. 6; CAE51894).	might get lost (downstream of altered splice site)
1894	1894	CONFLICT	W -> G (in Ref. 6; CAE51894).	might get lost (downstream of altered splice site)

length of protein

normal

AA sequence altered

yes

position of stopcodon in wt / mu CDS

5496 / 5496

position (AA) of stopcodon in wt / mu AA sequence

1832 / 1832

position of stopcodon in wt / mu cDNA

5696 / 5696

poly(A) signal

N/A

conservation
nucleotide level for all changes - no scoring up to now

N/A

position of start ATG in wt / mu cDNA

201 / 201

chromosome

strand

last intron/exon boundary

5581

theoretical NMD boundary in CDS

5330

length of CDS

5496

coding sequence (CDS) position

3351

cDNA position
(for ins/del: last normal base / first normal base)

3551

gDNA position
(for ins/del: last normal base / first normal base)

64656

chromosomal position
(for ins/del: last normal base / first normal base)

159655084

original gDNA sequence snippet

TCGGTCTCAGCCGAGGACGACGAGGAGGAGGACGCGGGATT

altered gDNA sequence snippet

TCGGTCTCAGCCGAGGACGAGGAGGAGGAGGACGCGGGATT

original cDNA sequence snippet

TCGGTCTCAGCCGAGGACGACGAGGAGGAGGACGCGGGATT

altered cDNA sequence snippet

TCGGTCTCAGCCGAGGACGAGGAGGAGGAGGACGCGGGATT

wildtype AA sequence

MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD
PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS
RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP
RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR
SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR
YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT
TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKASKADVE QNTEDNGKPE KPEPSSPSPR
APASSQHPSV PASPQGRNAK DLLLDLKNKI LANGGAPRKP QLRAKKAEEL DLQSTEITGE
EELGSREDSP MSPSDTQDQK RTLRPPSRHG HSVVAPGRTA VRARMPALPR REGVDKPGFS
LATQPRPGAP PSASASPAHH ASTQGTSHRP SLPASLNDND LVDSDEDERA VGSLHPKGAF
AQPRPALSPS RQSPSSVLRD RSSVHPGAKP ASPARRTPHS GAAEEDSSAS APPSRLSPPH
GGSSRLLPTQ PHLSSPLSKG GKDGEDAPAT NSNAPSRSTM SSSVSSHLSS RTQVSEGAEA
SDGESHGDGD REDGGRQAEA TAQTLRARPA SGHFHLLRHK PFAANGRSPS RFSIGRGPRL
QPSSSPQSTV PSRAHPRVPS HSDSHPKLSS GIHGDEEDEK PLPATVVNDH VPSSSRQPIS
RGWEDLRRSP QRGASLHRKE PIPENPKSTG ADTHPQGKYS SLASKAQDVQ QSTDADTEGH
SPKAQPGSTD RHASPARPPA ARSQQHPSVP RRMTPGRAPQ QQPPPPVATS QHHPGPQSRD
AGRSPSQPRL SLTQAGRPRP TSQGRSHSSS DPYTASSRGM LPTALQNQDE DAQGSYDDDS
TEVEAQDVRA PAHAARAKEA AASLPKHQQV ESPTGAGAGG DHRSQRGHAA SPARPSRPGG
PQSRARVPSR AAPGKSEPPS KRPLSSKSQQ SVSAEDDEEE DAGFFKGGKE DLLSSSVPKW
PSSSTPRGGK DADGSLAKEE REPAIALAPR GGSLAPVKRP LPPPPGSSPR ASHVPSRLPP
RSAATVSPVA GTHPWPQYTT RAPPGHFSTT PMLSLRQRMM HARFRNPLSR QPARPSYRQG
YNGRPNVEGK VLPGSNGKPN GQRIINGPQG TKWVVDLDRG LVLNAEGRYL QDSHGNPLRI
KLGGDGRTIV DLEGTPVVSP DGLPLFGQGR HGTPLANAQD KPILSLGGKP LVGLEVIKKT
THPPTTTMQP TTTTTPLPTT TTPRPTTATT RRTTTTRRTT TRRPTTTVRT TTRTTTTTTP
TPTTPIPTCP PGTLERHDDD GNLIMSSNGI PECYAEEDEF SGLETDTAVP TEEAYVIYDE
DYEFETSRPP TTTEPSTTAT TPRVIPEEGA ISSFPEEEFD LAGRKRFVAP YVTYLNKDPS
APCSLTDALD HFQVDSLDEI IPNDLKKSDL PPQHAPRNIT VVAVEGCHSF VIVDWDKATP
GDVVTGYLVY SASYEDFIRN KWSTQASSVT HLPIENLKPN TRYYFKVQAQ NPHGYGPISP
SVSFVTESDN PLLVVRPPGG EPIWIPFAFK HDPSYTDCHG RQYVKRTWYR KFVGVVLCNS
LRYKIYLSDN LKDTFYSIGD SWGRGEDHCQ FVDSHLDGRT GPQSYVEALP TIQGYYRQYR
QEPVRFGNIG FGTPYYYVGW YECGVSIPGK W*

mutated AA sequence

MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD
PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS
RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP
RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR
SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR
YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT
TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKASKADVE QNTEDNGKPE KPEPSSPSPR
APASSQHPSV PASPQGRNAK DLLLDLKNKI LANGGAPRKP QLRAKKAEEL DLQSTEITGE
EELGSREDSP MSPSDTQDQK RTLRPPSRHG HSVVAPGRTA VRARMPALPR REGVDKPGFS
LATQPRPGAP PSASASPAHH ASTQGTSHRP SLPASLNDND LVDSDEDERA VGSLHPKGAF
AQPRPALSPS RQSPSSVLRD RSSVHPGAKP ASPARRTPHS GAAEEDSSAS APPSRLSPPH
GGSSRLLPTQ PHLSSPLSKG GKDGEDAPAT NSNAPSRSTM SSSVSSHLSS RTQVSEGAEA
SDGESHGDGD REDGGRQAEA TAQTLRARPA SGHFHLLRHK PFAANGRSPS RFSIGRGPRL
QPSSSPQSTV PSRAHPRVPS HSDSHPKLSS GIHGDEEDEK PLPATVVNDH VPSSSRQPIS
RGWEDLRRSP QRGASLHRKE PIPENPKSTG ADTHPQGKYS SLASKAQDVQ QSTDADTEGH
SPKAQPGSTD RHASPARPPA ARSQQHPSVP RRMTPGRAPQ QQPPPPVATS QHHPGPQSRD
AGRSPSQPRL SLTQAGRPRP TSQGRSHSSS DPYTASSRGM LPTALQNQDE DAQGSYDDDS
TEVEAQDVRA PAHAARAKEA AASLPKHQQV ESPTGAGAGG DHRSQRGHAA SPARPSRPGG
PQSRARVPSR AAPGKSEPPS KRPLSSKSQQ SVSAEDEEEE DAGFFKGGKE DLLSSSVPKW
PSSSTPRGGK DADGSLAKEE REPAIALAPR GGSLAPVKRP LPPPPGSSPR ASHVPSRLPP
RSAATVSPVA GTHPWPQYTT RAPPGHFSTT PMLSLRQRMM HARFRNPLSR QPARPSYRQG
YNGRPNVEGK VLPGSNGKPN GQRIINGPQG TKWVVDLDRG LVLNAEGRYL QDSHGNPLRI
KLGGDGRTIV DLEGTPVVSP DGLPLFGQGR HGTPLANAQD KPILSLGGKP LVGLEVIKKT
THPPTTTMQP TTTTTPLPTT TTPRPTTATT RRTTTTRRTT TRRPTTTVRT TTRTTTTTTP
TPTTPIPTCP PGTLERHDDD GNLIMSSNGI PECYAEEDEF SGLETDTAVP TEEAYVIYDE
DYEFETSRPP TTTEPSTTAT TPRVIPEEGA ISSFPEEEFD LAGRKRFVAP YVTYLNKDPS
APCSLTDALD HFQVDSLDEI IPNDLKKSDL PPQHAPRNIT VVAVEGCHSF VIVDWDKATP
GDVVTGYLVY SASYEDFIRN KWSTQASSVT HLPIENLKPN TRYYFKVQAQ NPHGYGPISP
SVSFVTESDN PLLVVRPPGG EPIWIPFAFK HDPSYTDCHG RQYVKRTWYR KFVGVVLCNS
LRYKIYLSDN LKDTFYSIGD SWGRGEDHCQ FVDSHLDGRT GPQSYVEALP TIQGYYRQYR
QEPVRFGNIG FGTPYYYVGW YECGVSIPGK W*

speed

0.85 s

MutationTaster - study a chromosomal position

Results

Taster files

mutation t@sting

Prediction

polymorphism

mutation t@sting

Prediction

polymorphism

Problems