Yum, tasty mutations...

MutationTaster - study a chromosomal position

 MTQE documentation
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input seems to be ok - now mapping the variant to the different transcripts...
found 1 transcript(s)...
Querying Taster for transcript #1: ENST00000377833
MT speed 0 s - this script 2.813764 s

Results

genesymbolpredictionprobabilitymodelprediction
problem		splicingClinVaramino acid changesvariant typedbSNP IDprotein lengthfile
CUBNpolymorphism_automatic0.000728918434009018simple_aaeaffectedP1559Ssingle base exchangers1801231show file

Taster files

Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999271081565991 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
  • protein features (might be) affected
  • splice site changes
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr10:17024503G>AN/A show variant in all transcripts   IGV
HGNC symbol CUBN
Ensembl transcript ID ENST00000377833
Genbank transcript ID NM_001081
UniProt peptide O60494
alteration type single base exchange
alteration region CDS
DNA changes c.4675C>T
cDNA.4741C>T
g.147328C>T
AA changes P1559S Score: 74 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 1559
frameshift no
known variant Reference ID: rs1801231
databasehomozygous (A/A)heterozygousallele carriers
1000G10529682020
ExAC---
regulatory features N/A
phyloP / phastCons
PhyloPPhastCons
(flanking)1.10.945
-0.2910.871
(flanking)0.9830.965
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites
effectgDNA positionscorewt detection sequence exon-intron border
Acc increased147333wt: 0.26 / mu: 0.40wt: GACTTTGATCTTGAACCACAAGACTCTTGTATTATGGTAAG
mu: GACTTTGATCTTGAATCACAAGACTCTTGTATTATGGTAAG		 acaa|GACT
Acc increased147326wt: 0.82 / mu: 0.91wt: CTTCACTGACTTTGATCTTGAACCACAAGACTCTTGTATTA
mu: CTTCACTGACTTTGATCTTGAATCACAAGACTCTTGTATTA		 ttga|ACCA
Donor marginally increased147328wt: 0.9716 / mu: 0.9718 (marginal change - not scored)wt: TTGAACCACAAGACT
mu: TTGAATCACAAGACT		 GAAC|caca
Donor marginally increased147333wt: 0.2651 / mu: 0.2825 (marginal change - not scored)wt: CCACAAGACTCTTGT
mu: TCACAAGACTCTTGT		 ACAA|gact
distance from splice site 21
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      1559VLLNFTDFDLEPQDSCIMAYDGLS
mutated  not conserved    1559VLLNFTDFDLESQDSCIMAYDGL
Ptroglodytes  all identical  ENSPTRG00000002326  1559VLLNFTDFDLEPQDSCIMAYDGL
Mmulatta  no homologue    
Fcatus  all identical  ENSFCAG00000013560  1557VLLNFTDFDLEPQDSCIMAYDGV
Mmusculus  not conserved  ENSMUSG00000026726  1559VLLNITDFDLEATDSCLMTYDGS
Ggallus  not conserved  ENSGALG00000008704  1567IEDHRLCNYDNVTVFDGP
Trubripes  no homologue    
Drerio  no homologue    
Dmelanogaster  not conserved  FBgn0004885  1207NEFDVESHQECTYDNVAVYDGE
Celegans  not conserved  F38E9.2  431VAIEFVYFHLEQHKECIYDRLIL
Xtropicalis  not conserved  ENSXETG00000007453  1577VLLTFRDFDIESHSSCSFDSVTVFDGP
protein features
start (aa)end (aa)featuredetails 
15101619DOMAINCUB 10.lost
15631563DISULFIDBy similarity.might get lost (downstream of altered splice site)
15811581DISULFIDBy similarity.might get lost (downstream of altered splice site)
16201620DISULFIDBy similarity.might get lost (downstream of altered splice site)
16201734DOMAINCUB 11.might get lost (downstream of altered splice site)
16461646CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
16471647DISULFIDBy similarity.might get lost (downstream of altered splice site)
16751675DISULFIDBy similarity.might get lost (downstream of altered splice site)
16971697DISULFIDBy similarity.might get lost (downstream of altered splice site)
17381738DISULFIDBy similarity.might get lost (downstream of altered splice site)
17381850DOMAINCUB 12.might get lost (downstream of altered splice site)
17641764DISULFIDBy similarity.might get lost (downstream of altered splice site)
17911791DISULFIDBy similarity.might get lost (downstream of altered splice site)
18021802CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
18121812DISULFIDBy similarity.might get lost (downstream of altered splice site)
18191819CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
18521963DOMAINCUB 13.might get lost (downstream of altered splice site)
18851885CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
19051905DISULFIDBy similarity.might get lost (downstream of altered splice site)
19271927DISULFIDBy similarity.might get lost (downstream of altered splice site)
19781978DISULFIDBy similarity.might get lost (downstream of altered splice site)
19782091DOMAINCUB 14.might get lost (downstream of altered splice site)
20062006DISULFIDBy similarity.might get lost (downstream of altered splice site)
20322032DISULFIDBy similarity.might get lost (downstream of altered splice site)
20542054DISULFIDBy similarity.might get lost (downstream of altered splice site)
20852085CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
20922092DISULFIDBy similarity.might get lost (downstream of altered splice site)
20922213DOMAINCUB 15.might get lost (downstream of altered splice site)
21172117CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
21182118DISULFIDBy similarity.might get lost (downstream of altered splice site)
22172217DISULFIDBy similarity.might get lost (downstream of altered splice site)
22172334DOMAINCUB 16.might get lost (downstream of altered splice site)
22472247DISULFIDBy similarity.might get lost (downstream of altered splice site)
22742274CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
22752275DISULFIDBy similarity.might get lost (downstream of altered splice site)
22972297DISULFIDBy similarity.might get lost (downstream of altered splice site)
23362336DISULFIDBy similarity.might get lost (downstream of altered splice site)
23362448DOMAINCUB 17.might get lost (downstream of altered splice site)
23632363DISULFIDBy similarity.might get lost (downstream of altered splice site)
23862386CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
23902390DISULFIDBy similarity.might get lost (downstream of altered splice site)
24002400CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
24112411DISULFIDBy similarity.might get lost (downstream of altered splice site)
24522452DISULFIDBy similarity.might get lost (downstream of altered splice site)
24522565DOMAINCUB 18.might get lost (downstream of altered splice site)
24782478DISULFIDBy similarity.might get lost (downstream of altered splice site)
25052505DISULFIDBy similarity.might get lost (downstream of altered splice site)
25272527DISULFIDBy similarity.might get lost (downstream of altered splice site)
25312531CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
25702570DISULFIDBy similarity.might get lost (downstream of altered splice site)
25702687DOMAINCUB 19.might get lost (downstream of altered splice site)
25812581CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
25922592CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
25992599DISULFIDBy similarity.might get lost (downstream of altered splice site)
26102610CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
26282628DISULFIDBy similarity.might get lost (downstream of altered splice site)
26492649DISULFIDBy similarity.might get lost (downstream of altered splice site)
26892689DISULFIDBy similarity.might get lost (downstream of altered splice site)
26892801DOMAINCUB 20.might get lost (downstream of altered splice site)
27152715DISULFIDBy similarity.might get lost (downstream of altered splice site)
27422742DISULFIDBy similarity.might get lost (downstream of altered splice site)
27642764DISULFIDBy similarity.might get lost (downstream of altered splice site)
28052805DISULFIDBy similarity.might get lost (downstream of altered splice site)
28052919DOMAINCUB 21.might get lost (downstream of altered splice site)
28132813CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
28312831DISULFIDBy similarity.might get lost (downstream of altered splice site)
28602860DISULFIDBy similarity.might get lost (downstream of altered splice site)
28832883DISULFIDBy similarity.might get lost (downstream of altered splice site)
29202920DISULFIDBy similarity.might get lost (downstream of altered splice site)
29203035DOMAINCUB 22.might get lost (downstream of altered splice site)
29232923CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
29452945CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
29462946DISULFIDBy similarity.might get lost (downstream of altered splice site)
29772977DISULFIDBy similarity.might get lost (downstream of altered splice site)
29992999DISULFIDBy similarity.might get lost (downstream of altered splice site)
30373037DISULFIDBy similarity.might get lost (downstream of altered splice site)
30373150DOMAINCUB 23.might get lost (downstream of altered splice site)
30423042CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
30643064DISULFIDBy similarity.might get lost (downstream of altered splice site)
30913091DISULFIDBy similarity.might get lost (downstream of altered splice site)
31033103CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
31133113DISULFIDBy similarity.might get lost (downstream of altered splice site)
31253125CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
31573157DISULFIDBy similarity.might get lost (downstream of altered splice site)
31573274DOMAINCUB 24.might get lost (downstream of altered splice site)
31653165CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
31853185DISULFIDBy similarity.might get lost (downstream of altered splice site)
32153215DISULFIDBy similarity.might get lost (downstream of altered splice site)
32373237DISULFIDBy similarity.might get lost (downstream of altered splice site)
32683268CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
32783278DISULFIDBy similarity.might get lost (downstream of altered splice site)
32783393DOMAINCUB 25.might get lost (downstream of altered splice site)
32833283CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
32903290CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
32953295CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
33063306DISULFIDBy similarity.might get lost (downstream of altered splice site)
33323332DISULFIDBy similarity.might get lost (downstream of altered splice site)
33543354DISULFIDBy similarity.might get lost (downstream of altered splice site)
33573357CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
33953395DISULFIDBy similarity.might get lost (downstream of altered splice site)
33953507DOMAINCUB 26.might get lost (downstream of altered splice site)
34213421DISULFIDBy similarity.might get lost (downstream of altered splice site)
34303430CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
34483448DISULFIDBy similarity.might get lost (downstream of altered splice site)
34573457CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
34703470DISULFIDBy similarity.might get lost (downstream of altered splice site)
35113511DISULFIDBy similarity.might get lost (downstream of altered splice site)
35113623DOMAINCUB 27.might get lost (downstream of altered splice site)
35333533CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
35373537DISULFIDBy similarity.might get lost (downstream of altered splice site)
35643564DISULFIDBy similarity.might get lost (downstream of altered splice site)
35763576CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
35863586DISULFIDBy similarity.might get lost (downstream of altered splice site)
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 10872 / 10872
position (AA) of stopcodon in wt / mu AA sequence 3624 / 3624
position of stopcodon in wt / mu cDNA 10938 / 10938
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 67 / 67
chromosome 10
strand -1
last intron/exon boundary 10831
theoretical NMD boundary in CDS 10714
length of CDS 10872
coding sequence (CDS) position 4675
cDNA position
(for ins/del: last normal base / first normal base)		 4741
gDNA position
(for ins/del: last normal base / first normal base)		 147328
chromosomal position
(for ins/del: last normal base / first normal base)		 17024503
original gDNA sequence snippet TCACTGACTTTGATCTTGAACCACAAGACTCTTGTATTATG
altered gDNA sequence snippet TCACTGACTTTGATCTTGAATCACAAGACTCTTGTATTATG
original cDNA sequence snippet TCACTGACTTTGATCTTGAACCACAAGACTCTTGTATTATG
altered cDNA sequence snippet TCACTGACTTTGATCTTGAATCACAAGACTCTTGTATTATG
wildtype AA sequence MMNMSLPFLW SLLTLLIFAE VNGEAGELEL QRQKRSINLQ QPRMATERGN LVFLTGSAQN
IEFRTGSLGK IKLNDEDLSE CLHQIQKNKE DIIELKGSAI GLPQNISSQI YQLNSKLVDL
ERKFQGLQQT VDKKVCSSNP CQNGGTCLNL HDSFFCICPP QWKGPLCSAD VNECEIYSGT
PLSCQNGGTC VNTMGSYSCH CPPETYGPQC ASKYDDCEGG SVARCVHGIC EDLMREQAGE
PKYSCVCDAG WMFSPNSPAC TLDRDECSFQ PGPCSTLVQC FNTQGSFYCG ACPTGWQGNG
YICEDINECE INNGGCSVAP PVECVNTPGS SHCQACPPGY QGDGRVCTLT DICSVSNGGC
HPDASCSSTL GSLPLCTCLP GYTGNGYGPN GCVQLSNICL SHPCLNGQCI DTVSGYFCKC
DSGWTGVNCT ENINECLSNP CLNGGTCVDG VDSFSCECTR LWTGALCQVP QQVCGESLSG
INGSFSYRSP DVGYVHDVNC FWVIKTEMGK VLRITFTFFR LESMDNCPHE FLQVYDGDSS
SAFQLGRFCG SSLPHELLSS DNALYFHLYS EHLRNGRGFT VRWETQQPEC GGILTGPYGS
IKSPGYPGNY PPGRDCVWIV VTSPDLLVTF TFGTLSLEHH DDCNKDYLEI RDGPLYQDPL
LGKFCTTFSV PPLQTTGPFA RIHFHSDSQI SDQGFHITYL TSPSDLRCGG NYTDPEGELF
LPELSGPFTH TRQCVYMMKQ PQGEQIQINF THVELQCQSD SSQNYIEVRD GETLLGKVCG
NGTISHIKSI TNSVWIRFKI DASVEKASFR AVYQVACGDE LTGEGVIRSP FFPNVYPGER
TCRWTIHQPQ SQVILLNFTV FEIGSSAHCE TDYVEIGSSS ILGSPENKKY CGTDIPSFIT
SVYNFLYVTF VKSSSTENHG FMAKFSAEDL ACGEILTEST GTIQSPGHPN VYPHGINCTW
HILVQPNHLI HLMFETFHLE FHYNCTNDYL EVYDTDSETS LGRYCGKSIP PSLTSSGNSL
MLVFVTDSDL AYEGFLINYE AISAATACLQ DYTDDLGTFT SPNFPNNYPN NWECIYRITV
RTGQLIAVHF TNFSLEEAIG NYYTDFLEIR DGGYEKSPLL GIFYGSNLPP TIISHSNKLW
LKFKSDQIDT RSGFSAYWDG SSTGCGGNLT TSSGTFISPN YPMPYYHSSE CYWWLKSSHG
SAFELEFKDF HLEHHPNCTL DYLAVYDGPS SNSHLLTQLC GDEKPPLIRS SGDSMFIKLR
TDEGQQGRGF KAEYRQTCEN VVIVNQTYGI LESIGYPNPY SENQHCNWTI RATTGNTVNY
TFLAFDLEHH INCSTDYLEL YDGPRQMGRY CGVDLPPPGS TTSSKLQVLL LTDGVGRREK
GFQMQWFVYG CGGELSGATG SFSSPGFPNR YPPNKECIWY IRTDPGSSIQ LTIHDFDVEY
HSRCNFDVLE IYGGPDFHSP RIAQLCTQRS PENPMQVSST GNELAIRFKT DLSINGRGFN
ASWQAVTGGC GGIFQAPSGE IHSPNYPSPY RSNTDCSWVI RVDRNHRVLL NFTDFDLEPQ
DSCIMAYDGL SSTMSRLART CGREQLANPI VSSGNSLFLR FQSGPSRQNR GFRAQFRQAC
GGHILTSSFD TVSSPRFPAN YPNNQNCSWI IQAQPPLNHI TLSFTHFELE RSTTCARDFV
EILDGGHEDA PLRGRYCGTD MPHPITSFSS ALTLRFVSDS SISAGGFHTT VTASVSACGG
TFYMAEGIFN SPGYPDIYPP NVECVWNIVS SPGNRLQLSF ISFQLEDSQD CSRDFVEIRE
GNATGHLVGR YCGNSFPLNY SSIVGHTLWV RFISDGSGSG TGFQATFMKI FGNDNIVGTH
GKVASPFWPE NYPHNSNYQW TVNVNASHVV HGRILEMDIE EIQNCYYDKL RIYDGPSIHA
RLIGAYCGTQ TESFSSTGNS LTFHFYSDSS ISGKGFLLEW FAVDAPDGVL PTIAPGACGG
FLRTGDAPVF LFSPGWPDSY SNRVDCTWLI QAPDSTVELN ILSLDIESHR TCAYDSLVIR
DGDNNLAQQL AVLCGREIPG PIRSTGEYMF IRFTSDSSVT RAGFNASFHK SCGGYLHADR
GIITSPKYPE TYPSNLNCSW HVLVQSGLTI AVHFEQPFQI PNGDSSCNQG DYLVLRNGPD
ICSPPLGPPG GNGHFCGSHA SSTLFTSDNQ MFVQFISDHS NEGQGFKIKY EAKSLACGGN
VYIHDADSAG YVTSPNHPHN YPPHADCIWI LAAPPETRIQ LQFEDRFDIE VTPNCTSNYL
ELRDGVDSDA PILSKFCGTS LPSSQWSSGE VMYLRFRSDN SPTHVGFKAK YSIAQCGGRV
PGQSGVVESI GHPTLPYRDN LFCEWHLQGL SGHYLTISFE DFNLQNSSGC EKDFVEIWDN
HTSGNILGRY CGNTIPDSID TSSNTAVVRF VTDGSVTASG FRLRFESSME ECGGDLQGSI
GTFTSPNYPN PNPHGRICEW RITAPEGRRI TLMFNNLRLA THPSCNNEHV IVFNGIRSNS
PQLEKLCSSV NVSNEIKSSG NTMKVIFFTD GSRPYGGFTA SYTSSEDAVC GGSLPNTPEG
NFTSPGYDGV RNYSRNLNCE WTLSNPNQGN SSISIHFEDF YLESHQDCQF DVLEFRVGDA
DGPLMWRLCG PSKPTLPLVI PYSQVWIHFV TNERVEHIGF HAKYSFTDCG GIQIGDSGVI
TSPNYPNAYD SLTHCSSLLE APQGHTITLT FSDFDIEPHT TCAWDSVTVR NGGSPESPII
GQYCGNSNPR TIQSGSNQLV VTFNSDHSLQ GGGFYATWNT QTLGCGGIFH SDNGTIRSPH
WPQNFPENSR CSWTAITHKS KHLEISFDNN FLIPSGDGQC QNSFVKVWAG TEEVDKALLA
TGCGNVAPGP VITPSNTFTA VFQSQEAPAQ GFSASFVSRC GSNFTGPSGY IISPNYPKQY
DNNMNCTYVI EANPLSVVLL TFVSFHLEAR SAVTGSCVND GVHIIRGYSV MSTPFATVCG
DEMPAPLTIA GPVLLNFYSN EQITDFGFKF SYRIISCGGV FNFSSGIITS PAYSYADYPN
DMHCLYTITV SDDKVIELKF SDFDVVPSTS CSHDYLAIYD GANTSDPLLG KFCGSKRPPN
VKSSNNSMLL VFKTDSFQTA KGWKMSFRQT LGPQQGCGGY LTGSNNTFAS PDSDSNGMYD
KNLNCVWIII APVNKVIHLT FNTFALEAAS TRQRCLYDYV KLYDGDSENA NLAGTFCGST
VPAPFISSGN FLTVQFISDL TLEREGFNAT YTIMDMPCGG TYNATWTPQN ISSPNSSDPD
VPFSICTWVI DSPPHQQVKI TVWALQLTSQ DCTQNYLQLQ DSPQGHGNSR FQFCGRNASA
VPVFYSSMST AMVIFKSGVV NRNSRMSFTY QIADCNRDYH KAFGNLRSPG WPDNYDNDKD
CTVTLTAPQN HTISLFFHSL GIENSVECRN DFLEVRNGSN SNSPLLGKYC GTLLPNPVFS
QNNELYLRFK SDSVTSDRGY EIIWTSSPSG CGGTLYGDRG SFTSPGYPGT YPNNTYCEWV
LVAPAGRLVT INFYFISIDD PGDCVQNYLT LYDGPNASSP SSGPYCGGDT SIAPFVASSN
QVFIKFHADY ARRPSAFRLT WDS*
mutated AA sequence MMNMSLPFLW SLLTLLIFAE VNGEAGELEL QRQKRSINLQ QPRMATERGN LVFLTGSAQN
IEFRTGSLGK IKLNDEDLSE CLHQIQKNKE DIIELKGSAI GLPQNISSQI YQLNSKLVDL
ERKFQGLQQT VDKKVCSSNP CQNGGTCLNL HDSFFCICPP QWKGPLCSAD VNECEIYSGT
PLSCQNGGTC VNTMGSYSCH CPPETYGPQC ASKYDDCEGG SVARCVHGIC EDLMREQAGE
PKYSCVCDAG WMFSPNSPAC TLDRDECSFQ PGPCSTLVQC FNTQGSFYCG ACPTGWQGNG
YICEDINECE INNGGCSVAP PVECVNTPGS SHCQACPPGY QGDGRVCTLT DICSVSNGGC
HPDASCSSTL GSLPLCTCLP GYTGNGYGPN GCVQLSNICL SHPCLNGQCI DTVSGYFCKC
DSGWTGVNCT ENINECLSNP CLNGGTCVDG VDSFSCECTR LWTGALCQVP QQVCGESLSG
INGSFSYRSP DVGYVHDVNC FWVIKTEMGK VLRITFTFFR LESMDNCPHE FLQVYDGDSS
SAFQLGRFCG SSLPHELLSS DNALYFHLYS EHLRNGRGFT VRWETQQPEC GGILTGPYGS
IKSPGYPGNY PPGRDCVWIV VTSPDLLVTF TFGTLSLEHH DDCNKDYLEI RDGPLYQDPL
LGKFCTTFSV PPLQTTGPFA RIHFHSDSQI SDQGFHITYL TSPSDLRCGG NYTDPEGELF
LPELSGPFTH TRQCVYMMKQ PQGEQIQINF THVELQCQSD SSQNYIEVRD GETLLGKVCG
NGTISHIKSI TNSVWIRFKI DASVEKASFR AVYQVACGDE LTGEGVIRSP FFPNVYPGER
TCRWTIHQPQ SQVILLNFTV FEIGSSAHCE TDYVEIGSSS ILGSPENKKY CGTDIPSFIT
SVYNFLYVTF VKSSSTENHG FMAKFSAEDL ACGEILTEST GTIQSPGHPN VYPHGINCTW
HILVQPNHLI HLMFETFHLE FHYNCTNDYL EVYDTDSETS LGRYCGKSIP PSLTSSGNSL
MLVFVTDSDL AYEGFLINYE AISAATACLQ DYTDDLGTFT SPNFPNNYPN NWECIYRITV
RTGQLIAVHF TNFSLEEAIG NYYTDFLEIR DGGYEKSPLL GIFYGSNLPP TIISHSNKLW
LKFKSDQIDT RSGFSAYWDG SSTGCGGNLT TSSGTFISPN YPMPYYHSSE CYWWLKSSHG
SAFELEFKDF HLEHHPNCTL DYLAVYDGPS SNSHLLTQLC GDEKPPLIRS SGDSMFIKLR
TDEGQQGRGF KAEYRQTCEN VVIVNQTYGI LESIGYPNPY SENQHCNWTI RATTGNTVNY
TFLAFDLEHH INCSTDYLEL YDGPRQMGRY CGVDLPPPGS TTSSKLQVLL LTDGVGRREK
GFQMQWFVYG CGGELSGATG SFSSPGFPNR YPPNKECIWY IRTDPGSSIQ LTIHDFDVEY
HSRCNFDVLE IYGGPDFHSP RIAQLCTQRS PENPMQVSST GNELAIRFKT DLSINGRGFN
ASWQAVTGGC GGIFQAPSGE IHSPNYPSPY RSNTDCSWVI RVDRNHRVLL NFTDFDLESQ
DSCIMAYDGL SSTMSRLART CGREQLANPI VSSGNSLFLR FQSGPSRQNR GFRAQFRQAC
GGHILTSSFD TVSSPRFPAN YPNNQNCSWI IQAQPPLNHI TLSFTHFELE RSTTCARDFV
EILDGGHEDA PLRGRYCGTD MPHPITSFSS ALTLRFVSDS SISAGGFHTT VTASVSACGG
TFYMAEGIFN SPGYPDIYPP NVECVWNIVS SPGNRLQLSF ISFQLEDSQD CSRDFVEIRE
GNATGHLVGR YCGNSFPLNY SSIVGHTLWV RFISDGSGSG TGFQATFMKI FGNDNIVGTH
GKVASPFWPE NYPHNSNYQW TVNVNASHVV HGRILEMDIE EIQNCYYDKL RIYDGPSIHA
RLIGAYCGTQ TESFSSTGNS LTFHFYSDSS ISGKGFLLEW FAVDAPDGVL PTIAPGACGG
FLRTGDAPVF LFSPGWPDSY SNRVDCTWLI QAPDSTVELN ILSLDIESHR TCAYDSLVIR
DGDNNLAQQL AVLCGREIPG PIRSTGEYMF IRFTSDSSVT RAGFNASFHK SCGGYLHADR
GIITSPKYPE TYPSNLNCSW HVLVQSGLTI AVHFEQPFQI PNGDSSCNQG DYLVLRNGPD
ICSPPLGPPG GNGHFCGSHA SSTLFTSDNQ MFVQFISDHS NEGQGFKIKY EAKSLACGGN
VYIHDADSAG YVTSPNHPHN YPPHADCIWI LAAPPETRIQ LQFEDRFDIE VTPNCTSNYL
ELRDGVDSDA PILSKFCGTS LPSSQWSSGE VMYLRFRSDN SPTHVGFKAK YSIAQCGGRV
PGQSGVVESI GHPTLPYRDN LFCEWHLQGL SGHYLTISFE DFNLQNSSGC EKDFVEIWDN
HTSGNILGRY CGNTIPDSID TSSNTAVVRF VTDGSVTASG FRLRFESSME ECGGDLQGSI
GTFTSPNYPN PNPHGRICEW RITAPEGRRI TLMFNNLRLA THPSCNNEHV IVFNGIRSNS
PQLEKLCSSV NVSNEIKSSG NTMKVIFFTD GSRPYGGFTA SYTSSEDAVC GGSLPNTPEG
NFTSPGYDGV RNYSRNLNCE WTLSNPNQGN SSISIHFEDF YLESHQDCQF DVLEFRVGDA
DGPLMWRLCG PSKPTLPLVI PYSQVWIHFV TNERVEHIGF HAKYSFTDCG GIQIGDSGVI
TSPNYPNAYD SLTHCSSLLE APQGHTITLT FSDFDIEPHT TCAWDSVTVR NGGSPESPII
GQYCGNSNPR TIQSGSNQLV VTFNSDHSLQ GGGFYATWNT QTLGCGGIFH SDNGTIRSPH
WPQNFPENSR CSWTAITHKS KHLEISFDNN FLIPSGDGQC QNSFVKVWAG TEEVDKALLA
TGCGNVAPGP VITPSNTFTA VFQSQEAPAQ GFSASFVSRC GSNFTGPSGY IISPNYPKQY
DNNMNCTYVI EANPLSVVLL TFVSFHLEAR SAVTGSCVND GVHIIRGYSV MSTPFATVCG
DEMPAPLTIA GPVLLNFYSN EQITDFGFKF SYRIISCGGV FNFSSGIITS PAYSYADYPN
DMHCLYTITV SDDKVIELKF SDFDVVPSTS CSHDYLAIYD GANTSDPLLG KFCGSKRPPN
VKSSNNSMLL VFKTDSFQTA KGWKMSFRQT LGPQQGCGGY LTGSNNTFAS PDSDSNGMYD
KNLNCVWIII APVNKVIHLT FNTFALEAAS TRQRCLYDYV KLYDGDSENA NLAGTFCGST
VPAPFISSGN FLTVQFISDL TLEREGFNAT YTIMDMPCGG TYNATWTPQN ISSPNSSDPD
VPFSICTWVI DSPPHQQVKI TVWALQLTSQ DCTQNYLQLQ DSPQGHGNSR FQFCGRNASA
VPVFYSSMST AMVIFKSGVV NRNSRMSFTY QIADCNRDYH KAFGNLRSPG WPDNYDNDKD
CTVTLTAPQN HTISLFFHSL GIENSVECRN DFLEVRNGSN SNSPLLGKYC GTLLPNPVFS
QNNELYLRFK SDSVTSDRGY EIIWTSSPSG CGGTLYGDRG SFTSPGYPGT YPNNTYCEWV
LVAPAGRLVT INFYFISIDD PGDCVQNYLT LYDGPNASSP SSGPYCGGDT SIAPFVASSN
QVFIKFHADY ARRPSAFRLT WDS*
speed 0.76 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
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