Yum, tasty mutations...

MutationTaster - study a chromosomal position

 MTQE documentation
NEVER press reload or F5 - unless you want to start from the very beginning.
input seems to be ok - now mapping the variant to the different transcripts...
found 2 transcript(s)...
Querying Taster for transcript #1: ENST00000529681
Querying Taster for transcript #2: ENST00000447027
MT speed 0 s - this script 3.313213 s

Results

genesymbolpredictionprobabilitymodelprediction
problem		splicingClinVaramino acid changesvariant typedbSNP IDprotein lengthfile
MUC5Bpolymorphism_automatic1.29896093881143e-14simple_aaeaffectedS3500Gsingle base exchangers2943527show file
MUC5Bpolymorphism_automatic1.29896093881143e-14simple_aaeaffectedS3503Gsingle base exchangers2943527show file

Taster files

Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999999987 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
  • protein features (might be) affected
  • splice site changes
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr11:1268608A>GN/A show variant in all transcripts   IGV
HGNC symbol MUC5B
Ensembl transcript ID ENST00000529681
Genbank transcript ID NM_002458
UniProt peptide Q9HC84
alteration type single base exchange
alteration region CDS
DNA changes c.10498A>G
cDNA.10556A>G
g.24313A>G
AA changes S3500G Score: 56 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 3500
frameshift no
known variant Reference ID: rs2943527
databasehomozygous (G/G)heterozygousallele carriers
1000G108911032192
ExAC27336-219055431
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
DNase1, Open Chromatin, DNase1 Hypersensitive Site
phyloP / phastCons
PhyloPPhastCons
(flanking)-2.720
-1.7960
(flanking)-1.4720
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites
effectgDNA positionscorewt detection sequence exon-intron border
Donor gained243120.47mu: ACCACCGGTACCACC CACC|ggta
distance from splice site 4366
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      3500TVTSHTPAATTSTTQHSTPALSSP
mutated  not conserved    3500TVTSHTPAATTGTTQHSTPALSS
Ptroglodytes  no homologue    
Mmulatta  no homologue    
Fcatus  no homologue    
Mmusculus  all conserved  ENSMUSG00000066108  3606TSMPMTSTLPVTVTNATTP----
Ggallus  no homologue    
Trubripes  no homologue    
Drerio  all conserved  ENSDARG00000089847  3676TVTK-TTAVPVTTLVSTTVSVES
Dmelanogaster  no alignment  FBgn0029167  n/a
Celegans  no homologue    
Xtropicalis  no homologue    
protein features
start (aa)end (aa)featuredetails 
13334228REGION7 X Cys-rich subdomain repeats.lost
16084932COMPBIASThr-rich.lost
24683695CONFLICTMissing (in Ref. 6; AAB61398).lost
35003500CONFLICTS -> G (in Ref. 4; CAA96577).lost
35043504CONFLICTH -> P (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
35543586REPEATHAT 2.might get lost (downstream of altered splice site)
35713671REPEATCys-rich subdomain 6.might get lost (downstream of altered splice site)
35773577CARBOHYDC-linked (Man) (Probable).might get lost (downstream of altered splice site)
36764013REGION11 X approximate tandem repeats, Ser/Thr- rich.might get lost (downstream of altered splice site)
37163747CONFLICTPGTTWILTEPSTTATVTVPTGSTATASSTQAT -> QGPP (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
38113811CONFLICTQ -> P (in Ref. 6; AAB61398).might get lost (downstream of altered splice site)
38313831CONFLICTA -> V (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
38453845CONFLICTR -> G (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
39093909CONFLICTV -> I (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
39243925CONFLICTTT -> QP (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
39753975CONFLICTV -> E (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
40064006CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
40604061CONFLICTQH -> TT (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
41114143REPEATHAT 3.might get lost (downstream of altered splice site)
41144114CONFLICTS -> Q (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
41284228REPEATCys-rich subdomain 7.might get lost (downstream of altered splice site)
41344134CARBOHYDC-linked (Man) (Probable).might get lost (downstream of altered splice site)
41774177CONFLICTQ -> T (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
42334879REGION23 X approximate tandem repeats, Ser/Thr- rich.might get lost (downstream of altered splice site)
43134313CONFLICTS -> T (in Ref. 4; CAA52910).might get lost (downstream of altered splice site)
43734373CONFLICTMissing (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
44614463CONFLICTVPT -> APP (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
45674567CONFLICTA -> T (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
47804780CONFLICTT -> P (in Ref. 7; AAC51344).might get lost (downstream of altered splice site)
48044804CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
49604960CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
50175017CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
50245024CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
50465046CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
50745305DOMAINVWFD 4.might get lost (downstream of altered splice site)
50965096CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
51115111CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
51345134CONFLICTR -> A (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
51645164CONFLICTQ -> P (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
51875187CONFLICTR -> A (in Ref. 7; AAC51344 and 8; AAB65151).might get lost (downstream of altered splice site)
52155215CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
52895289CONFLICTP -> L (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
53045306CONFLICTNLV -> TLL (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
53335333CONFLICTA -> R (in Ref. 7; AAC51344).might get lost (downstream of altered splice site)
53975397CONFLICTD -> N (in Ref. 7; AAC51343/AAC51344).might get lost (downstream of altered splice site)
54125484DOMAINVWFC 2.might get lost (downstream of altered splice site)
54745474CONFLICTE -> R (in Ref. 9; CAA70926).might get lost (downstream of altered splice site)
54755475CONFLICTN -> T (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
54865486CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
55215587DOMAINVWFC 3.might get lost (downstream of altered splice site)
55265526CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
55655565CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
55665566CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56025602CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56125612CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56205620CONFLICTA -> S (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
56325632CONFLICTA -> D (in Ref. 7; AAC51343).might get lost (downstream of altered splice site)
56535653DISULFIDBy similarity.might get lost (downstream of altered splice site)
56535742DOMAINCTCK.might get lost (downstream of altered splice site)
56605660CONFLICTV -> C (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
56635663CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56725672DISULFIDBy similarity.might get lost (downstream of altered splice site)
56775677CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56815681DISULFIDBy similarity.might get lost (downstream of altered splice site)
56855685DISULFIDBy similarity.might get lost (downstream of altered splice site)
57055705DISULFIDBy similarity.might get lost (downstream of altered splice site)
57195719DISULFIDBy similarity.might get lost (downstream of altered splice site)
57215721CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
57355735DISULFIDBy similarity.might get lost (downstream of altered splice site)
57375737DISULFIDBy similarity.might get lost (downstream of altered splice site)
57415741DISULFIDBy similarity.might get lost (downstream of altered splice site)
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 17289 / 17289
position (AA) of stopcodon in wt / mu AA sequence 5763 / 5763
position of stopcodon in wt / mu cDNA 17347 / 17347
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 59 / 59
chromosome 11
strand 1
last intron/exon boundary 17128
theoretical NMD boundary in CDS 17019
length of CDS 17289
coding sequence (CDS) position 10498
cDNA position
(for ins/del: last normal base / first normal base)		 10556
gDNA position
(for ins/del: last normal base / first normal base)		 24313
chromosomal position
(for ins/del: last normal base / first normal base)		 1268608
original gDNA sequence snippet ACACCCCAGCAGCAACCACCAGTACCACCCAGCACTCGACT
altered gDNA sequence snippet ACACCCCAGCAGCAACCACCGGTACCACCCAGCACTCGACT
original cDNA sequence snippet ACACCCCAGCAGCAACCACCAGTACCACCCAGCACTCGACT
altered cDNA sequence snippet ACACCCCAGCAGCAACCACCGGTACCACCCAGCACTCGACT
wildtype AA sequence MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT RRVSFVPPVT
VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN YVFSEHCRAA YEDFNVQLRR
GLVGSRPVVT RVVIKAQGLV LEASNGSVLI NGQREELPYS RTGLLVEQSG DYIKVSIRLV
LTFLWNGEDS ALLELDPKYA NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP
TEQCPDPLPL PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ RAQLCEDHCV
DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF NTTCSSCTCS GGLWQCQDLP
CPGTCSVQGG AHISTYDEKL YDLHGDCSYV LSKKCADSSF TVLAELRKCG LTDNENCLKA
VTLSLDGGDT AIRVQADGGV FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL
VPLMQVFVRL DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA
RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF DTCNCERSED
CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR YAYVVDACQP TCRGLSEADV
TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK
LSCLGASLQK STGCAAPMVY LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG
LVSDGSGGCI AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD
GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT CSKAIKLFVE
SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM AVSWDRKTSV FIRLHQDYKG
RVCGLCGNFD DNAINDFATR SRSVVGDALE FGNSWKLSPS CPDALAPKDP CTANPFRKSW
AQKQCSILHG PTFAACRSQV DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG
LCVSWRTPDT CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC
PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI QCAHSLEACT
CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV ACPGTPATTP FTFTTAWVPH
STTSPALPVS TVCVREVCRW SSWYNGHRPE PGLGGGDFET FENLRQRGYQ VCPVLADIEC
RAAQLPDMPL EELGQQVDCD RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT
SPQPSLSAST EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT
TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ AESFPNWTLA
QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD DHCRGRATTP PPTTELETAT
TTTTQALFST PQPTSSPGLT RAPPASTTAV PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS
TEPTVPGVAT STLPTRSALP GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP
LTTSLAPTLT SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT
SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS LETGLTCKNE
DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST PGTTWILTKP TTTATTTAST
GSTATPTSTL RTAPPPKVLT TTATTPTVTS SKATPSSSPG TATALPALRS TATTPTATSV
TPIPSSSLGT TWTRLSQTTT PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS
STPGTAHTTK VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS STPGTTPIPP
VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR SLPPSSPHTV RTAWTSATSG
ILGTTHITEP STVTSHTLAA TTGTTQHSTP ALSSPHPSSR TTESPPSPGT TTPGHTTATS
RTTATATPSK TRTSTLLPSS PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT
YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF
NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG STATPSSTPG
TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA TTPTVTSSKA TPFSSPGTAT
ALPALRSTAT TPTATSFTAI PSSSLGTTWT RLSQTTTPTA TMSTATPSST PETVHTSTVL
TTTATTTGAT GSVATPSSTP GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP
TTRGSTVTPS SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLS
PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG TTQHSTPALS SPHPSSRTTE
SPPSPGTTTP GHTRATSRTT ATATPSKTRT STLLPSSPTS APITTVVTMG CEPQCAWSEW
LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF
GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA
TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT LPVLTSTATK
STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP ETTHTSTVLT TKATTTRATS
SMSTPSSTPG TTWILTELTT AATTTAATGP TATPSSTPGT TWILTEPSTT ATVTVPTGST
ATASSTRATA GTLKVLTSTA TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI
PSSSLGTAWT RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP
GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS SIPGTTHTAT
VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPIPPVLT
TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLP PSSPHTVRTA WTSATSGILG
TTHITEPSTV TSHTPAATTS TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT
ATATPSKTRT STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV GKFKMCFNYE
IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA TTTESTGSTA TPSSTPGTTW
ILTEPSTTAT VTVPTGSTAT ASSTQATAGT PHVSTTATTP TVTSSKATPF SSPGTATALP
ALRSTATTPT ATSFTAIPSS SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT
ATTTRATGSV ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS
GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT ATTITATGST
TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH TPPVPNTTAT THGRSLSPSS
PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH TPAATTGTTQ HSTPALSSPH PSSRTTESPP
SPGTTTPGHT TATSRTTATA TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY
SYPMPGPSGG DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV
CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL TELTTTATTT
ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS SPRTATTLPV LTSTATKSTA
TSVTPIPSST LGTTGTLPEQ TTTPVATMST IHPSSTPETT HTSTVLTTKA TTTRATSSTS
TPSSTPGTTW ILTELTTAAT TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP
SSTPGTTWIL TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS
PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA TPSSTPETVH
TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG FTATPSSSPG TALTPPVWIS
TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR VLTTTTTTVA TGSMATPSSS TQTSGTPPSL
TTTATTITAT GSTTNPSSTP GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS
TATKSTATSF TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT
RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE PSTIATVMVP
TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV GTTRTPAVLP SSLPTFSVST
VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ FFSPGEVIYN KTDRAGCHFY AVCNQHCDID
RFQGACPTSP PPVSSAPLSS PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD
PKPVANVTCV NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV
LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT MVHGKEEGLI
LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN GQVFQARLPY SLFHNNTEGQ
CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP
TPTPCPPQPL CDLMLSQVFA ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA
RGVCSDWRGA TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL
FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP CDAQGQPPPC
NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG QESICTQEEG DCCPTFRCRP
QLCSYNGTFY GVGATFPGAL PCHMCTCLSG DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG
QCCGECVQTA CLTPDGQPVQ LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC
RGSLRKTGCC YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH
QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH TRGFPAQEAT
AV*
mutated AA sequence MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT RRVSFVPPVT
VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN YVFSEHCRAA YEDFNVQLRR
GLVGSRPVVT RVVIKAQGLV LEASNGSVLI NGQREELPYS RTGLLVEQSG DYIKVSIRLV
LTFLWNGEDS ALLELDPKYA NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP
TEQCPDPLPL PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ RAQLCEDHCV
DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF NTTCSSCTCS GGLWQCQDLP
CPGTCSVQGG AHISTYDEKL YDLHGDCSYV LSKKCADSSF TVLAELRKCG LTDNENCLKA
VTLSLDGGDT AIRVQADGGV FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL
VPLMQVFVRL DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA
RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF DTCNCERSED
CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR YAYVVDACQP TCRGLSEADV
TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK
LSCLGASLQK STGCAAPMVY LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG
LVSDGSGGCI AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD
GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT CSKAIKLFVE
SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM AVSWDRKTSV FIRLHQDYKG
RVCGLCGNFD DNAINDFATR SRSVVGDALE FGNSWKLSPS CPDALAPKDP CTANPFRKSW
AQKQCSILHG PTFAACRSQV DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG
LCVSWRTPDT CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC
PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI QCAHSLEACT
CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV ACPGTPATTP FTFTTAWVPH
STTSPALPVS TVCVREVCRW SSWYNGHRPE PGLGGGDFET FENLRQRGYQ VCPVLADIEC
RAAQLPDMPL EELGQQVDCD RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT
SPQPSLSAST EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT
TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ AESFPNWTLA
QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD DHCRGRATTP PPTTELETAT
TTTTQALFST PQPTSSPGLT RAPPASTTAV PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS
TEPTVPGVAT STLPTRSALP GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP
LTTSLAPTLT SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT
SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS LETGLTCKNE
DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST PGTTWILTKP TTTATTTAST
GSTATPTSTL RTAPPPKVLT TTATTPTVTS SKATPSSSPG TATALPALRS TATTPTATSV
TPIPSSSLGT TWTRLSQTTT PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS
STPGTAHTTK VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS STPGTTPIPP
VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR SLPPSSPHTV RTAWTSATSG
ILGTTHITEP STVTSHTLAA TTGTTQHSTP ALSSPHPSSR TTESPPSPGT TTPGHTTATS
RTTATATPSK TRTSTLLPSS PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT
YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF
NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG STATPSSTPG
TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA TTPTVTSSKA TPFSSPGTAT
ALPALRSTAT TPTATSFTAI PSSSLGTTWT RLSQTTTPTA TMSTATPSST PETVHTSTVL
TTTATTTGAT GSVATPSSTP GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP
TTRGSTVTPS SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLS
PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG TTQHSTPALS SPHPSSRTTE
SPPSPGTTTP GHTRATSRTT ATATPSKTRT STLLPSSPTS APITTVVTMG CEPQCAWSEW
LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF
GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA
TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT LPVLTSTATK
STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP ETTHTSTVLT TKATTTRATS
SMSTPSSTPG TTWILTELTT AATTTAATGP TATPSSTPGT TWILTEPSTT ATVTVPTGST
ATASSTRATA GTLKVLTSTA TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI
PSSSLGTAWT RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP
GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS SIPGTTHTAT
VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPIPPVLT
TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLP PSSPHTVRTA WTSATSGILG
TTHITEPSTV TSHTPAATTG TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT
ATATPSKTRT STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV GKFKMCFNYE
IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA TTTESTGSTA TPSSTPGTTW
ILTEPSTTAT VTVPTGSTAT ASSTQATAGT PHVSTTATTP TVTSSKATPF SSPGTATALP
ALRSTATTPT ATSFTAIPSS SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT
ATTTRATGSV ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS
GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT ATTITATGST
TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH TPPVPNTTAT THGRSLSPSS
PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH TPAATTGTTQ HSTPALSSPH PSSRTTESPP
SPGTTTPGHT TATSRTTATA TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY
SYPMPGPSGG DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV
CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL TELTTTATTT
ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS SPRTATTLPV LTSTATKSTA
TSVTPIPSST LGTTGTLPEQ TTTPVATMST IHPSSTPETT HTSTVLTTKA TTTRATSSTS
TPSSTPGTTW ILTELTTAAT TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP
SSTPGTTWIL TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS
PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA TPSSTPETVH
TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG FTATPSSSPG TALTPPVWIS
TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR VLTTTTTTVA TGSMATPSSS TQTSGTPPSL
TTTATTITAT GSTTNPSSTP GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS
TATKSTATSF TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT
RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE PSTIATVMVP
TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV GTTRTPAVLP SSLPTFSVST
VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ FFSPGEVIYN KTDRAGCHFY AVCNQHCDID
RFQGACPTSP PPVSSAPLSS PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD
PKPVANVTCV NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV
LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT MVHGKEEGLI
LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN GQVFQARLPY SLFHNNTEGQ
CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP
TPTPCPPQPL CDLMLSQVFA ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA
RGVCSDWRGA TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL
FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP CDAQGQPPPC
NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG QESICTQEEG DCCPTFRCRP
QLCSYNGTFY GVGATFPGAL PCHMCTCLSG DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG
QCCGECVQTA CLTPDGQPVQ LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC
RGSLRKTGCC YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH
QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH TRGFPAQEAT
AV*
speed 0.64 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table
Yum, tasty mutations...

mutation t@sting

 documentation

Prediction

polymorphism

 Model: simple_aae, prob: 0.999999999999987 (classification due to TGP/ExAC, real probability is shown anyway)      (explain)
Summary
  • amino acid sequence changed
  • homozygous in TGP or ExAC
  • protein features (might be) affected
  • splice site changes
 hyperlink
analysed issue analysis result
name of alteration no title
alteration (phys. location) chr11:1268608A>GN/A show variant in all transcripts   IGV
HGNC symbol MUC5B
Ensembl transcript ID ENST00000447027
Genbank transcript ID N/A
UniProt peptide Q9HC84
alteration type single base exchange
alteration region CDS
DNA changes c.10507A>G
cDNA.10565A>G
g.24313A>G
AA changes S3503G Score: 56 explain score(s)
position(s) of altered AA
if AA alteration in CDS		 3503
frameshift no
known variant Reference ID: rs2943527
databasehomozygous (G/G)heterozygousallele carriers
1000G108911032192
ExAC27336-219055431
regulatory features H3K27me3, Histone, Histone 3 Lysine 27 Tri-Methylation
DNase1, Open Chromatin, DNase1 Hypersensitive Site
phyloP / phastCons
PhyloPPhastCons
(flanking)-2.720
-1.7960
(flanking)-1.4720
explain score(s) and/or inspect your position(s) in in UCSC Genome Browser
splice sites
effectgDNA positionscorewt detection sequence exon-intron border
Donor gained243120.47mu: ACCACCGGTACCACC CACC|ggta
distance from splice site 4366
Kozak consensus sequence altered? N/A
conservation
protein level for non-synonymous changes
speciesmatchgeneaaalignment
Human      3503TVTSHTPAATTSTTQHSTPALSSP
mutated  not conserved    3503TVTSHTPAATTGTTQHSTPALSS
Ptroglodytes  no homologue    
Mmulatta  no homologue    
Fcatus  no homologue    
Mmusculus  all conserved  ENSMUSG00000066108  3606TSMPMTSTLPVTVTNATTP----
Ggallus  no homologue    
Trubripes  no homologue    
Drerio  all conserved  ENSDARG00000089847  3676TVTK-TTAVPVTTLVSTTVSVES
Dmelanogaster  no alignment  FBgn0029167  n/a
Celegans  no homologue    
Xtropicalis  no homologue    
protein features
start (aa)end (aa)featuredetails 
13334228REGION7 X Cys-rich subdomain repeats.lost
16084932COMPBIASThr-rich.lost
24683695CONFLICTMissing (in Ref. 6; AAB61398).lost
35043504CONFLICTH -> P (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
35543586REPEATHAT 2.might get lost (downstream of altered splice site)
35713671REPEATCys-rich subdomain 6.might get lost (downstream of altered splice site)
35773577CARBOHYDC-linked (Man) (Probable).might get lost (downstream of altered splice site)
36764013REGION11 X approximate tandem repeats, Ser/Thr- rich.might get lost (downstream of altered splice site)
37163747CONFLICTPGTTWILTEPSTTATVTVPTGSTATASSTQAT -> QGPP (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
38113811CONFLICTQ -> P (in Ref. 6; AAB61398).might get lost (downstream of altered splice site)
38313831CONFLICTA -> V (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
38453845CONFLICTR -> G (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
39093909CONFLICTV -> I (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
39243925CONFLICTTT -> QP (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
39753975CONFLICTV -> E (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
40064006CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
40604061CONFLICTQH -> TT (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
41114143REPEATHAT 3.might get lost (downstream of altered splice site)
41144114CONFLICTS -> Q (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
41284228REPEATCys-rich subdomain 7.might get lost (downstream of altered splice site)
41344134CARBOHYDC-linked (Man) (Probable).might get lost (downstream of altered splice site)
41774177CONFLICTQ -> T (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
42334879REGION23 X approximate tandem repeats, Ser/Thr- rich.might get lost (downstream of altered splice site)
43134313CONFLICTS -> T (in Ref. 4; CAA52910).might get lost (downstream of altered splice site)
43734373CONFLICTMissing (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
44614463CONFLICTVPT -> APP (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
45674567CONFLICTA -> T (in Ref. 4; CAA96577).might get lost (downstream of altered splice site)
47804780CONFLICTT -> P (in Ref. 7; AAC51344).might get lost (downstream of altered splice site)
48044804CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
49604960CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
50175017CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
50245024CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
50465046CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
50745305DOMAINVWFD 4.might get lost (downstream of altered splice site)
50965096CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
51115111CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
51345134CONFLICTR -> A (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
51645164CONFLICTQ -> P (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
51875187CONFLICTR -> A (in Ref. 7; AAC51344 and 8; AAB65151).might get lost (downstream of altered splice site)
52155215CARBOHYDN-linked (GlcNAc...).might get lost (downstream of altered splice site)
52895289CONFLICTP -> L (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
53045306CONFLICTNLV -> TLL (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
53335333CONFLICTA -> R (in Ref. 7; AAC51344).might get lost (downstream of altered splice site)
53975397CONFLICTD -> N (in Ref. 7; AAC51343/AAC51344).might get lost (downstream of altered splice site)
54125484DOMAINVWFC 2.might get lost (downstream of altered splice site)
54745474CONFLICTE -> R (in Ref. 9; CAA70926).might get lost (downstream of altered splice site)
54755475CONFLICTN -> T (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
54865486CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
55215587DOMAINVWFC 3.might get lost (downstream of altered splice site)
55265526CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
55655565CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
55665566CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56025602CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56125612CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56205620CONFLICTA -> S (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
56325632CONFLICTA -> D (in Ref. 7; AAC51343).might get lost (downstream of altered splice site)
56535653DISULFIDBy similarity.might get lost (downstream of altered splice site)
56535742DOMAINCTCK.might get lost (downstream of altered splice site)
56605660CONFLICTV -> C (in Ref. 8; AAB65151).might get lost (downstream of altered splice site)
56635663CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56725672DISULFIDBy similarity.might get lost (downstream of altered splice site)
56775677CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
56815681DISULFIDBy similarity.might get lost (downstream of altered splice site)
56855685DISULFIDBy similarity.might get lost (downstream of altered splice site)
57055705DISULFIDBy similarity.might get lost (downstream of altered splice site)
57195719DISULFIDBy similarity.might get lost (downstream of altered splice site)
57215721CARBOHYDN-linked (GlcNAc...) (Potential).might get lost (downstream of altered splice site)
57355735DISULFIDBy similarity.might get lost (downstream of altered splice site)
57375737DISULFIDBy similarity.might get lost (downstream of altered splice site)
57415741DISULFIDBy similarity.might get lost (downstream of altered splice site)
length of protein normal
AA sequence altered yes
position of stopcodon in wt / mu CDS 17298 / 17298
position (AA) of stopcodon in wt / mu AA sequence 5766 / 5766
position of stopcodon in wt / mu cDNA 17356 / 17356
poly(A) signal N/A
conservation
nucleotide level for all changes - no scoring up to now		 N/A
position of start ATG in wt / mu cDNA 59 / 59
chromosome 11
strand 1
last intron/exon boundary 17137
theoretical NMD boundary in CDS 17028
length of CDS 17298
coding sequence (CDS) position 10507
cDNA position
(for ins/del: last normal base / first normal base)		 10565
gDNA position
(for ins/del: last normal base / first normal base)		 24313
chromosomal position
(for ins/del: last normal base / first normal base)		 1268608
original gDNA sequence snippet ACACCCCAGCAGCAACCACCAGTACCACCCAGCACTCGACT
altered gDNA sequence snippet ACACCCCAGCAGCAACCACCGGTACCACCCAGCACTCGACT
original cDNA sequence snippet ACACCCCAGCAGCAACCACCAGTACCACCCAGCACTCGACT
altered cDNA sequence snippet ACACCCCAGCAGCAACCACCGGTACCACCCAGCACTCGACT
wildtype AA sequence MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT RRVSFVPPVT
VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN YVFSEHCRAA YEDFNVQLRR
GLVGSRPVVT RVVIKAQGLV LEASNGSVLI NGQREELPYS RTGLLVEQSG DYIKVSIRLV
LTFLWNGEDS ALLELDPKYA NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP
TEQCPDPLPL PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ RAQLCEDHCV
DGCFCPPGRS CTVLDDITHS GCLPLGQCPC THGGRTYSPG TSFNTTCSSC TCSGGLWQCQ
DLPCPGTCSV QGGAHISTYD EKLYDLHGDC SYVLSKKCAD SSFTVLAELR KCGLTDNENC
LKAVTLSLDG GDTAIRVQAD GGVFLNSIYT QLPLSAANIT LFTPSSFFIV VQTGLGLQLL
VQLVPLMQVF VRLDPAHQGQ MCGLCGNFNQ NQADDFTALS GVVEATGAAF ANTWKAQAAC
ANARNSFEDP CSLSVENENY ARHWCSRLTD PNSAFSRCHS IINPKPFHSN CMFDTCNCER
SEDCLCAALS SYVHACAAKG VQLSDWRDGV CTKYMQNCPK SQRYAYVVDA CQPTCRGLSE
ADVTCSVSFV PVDGCTCPAG TFLNDAGACV PAQECPCYAH GTVLAPGEVV HDEGAVCSCT
GGKLSCLGAS LQKSTGCAAP MVYLDCSNSS AGTPGAECLR SCHTLDVGCF STHCVSGCVC
PPGLVSDGSG GCIAEEDCPC VHNEATYKPG ETIRVDCNTC TCRNRRWECS HRLCLGTCVA
YGDGHFITFD GDRYSFEGSC EYILAQDYCG DNTTHGTFRI VTENIPCGTT GTTCSKAIKL
FVESYELILQ EGTFKAVARG PGGDPPYKIR YMGIFLVIET HGMAVSWDRK TSVFIRLHQD
YKGRVCGLCG NFDDNAINDF ATRSRSVVGD ALEFGNSWKL SPSCPDALAP KDPCTANPFR
KSWAQKQCSI LHGPTFAACR SQVDSTKYYE ACVNDACACD SGGDCECFCT AVAAYAQACH
DAGLCVSWRT PDTCPLFCDF YNPHGGCEWH YQPCGAPCLK TCRNPSGHCL VDLPGLEGCY
PKCPPSQPFF NEDQMKCVAQ CGCYDKDGNY YDVGARVPTA ENCQSCNCTP SGIQCAHSLE
ACTCTYEDRT YSYQDVIYNT TDGLGACLIA ICGSNGTIIR KAVACPGTPA TTPFTFTTAW
VPHSTTSPAL PVSTVCVREV CRWSSWYNGH RPEPGLGGGD FETFENLRQR GYQVCPVLAD
IECRAAQLPD MPLEELGQQV DCDRMRGLMC ANSQQSPPLC HDYELRVLCC EYVPCGPSPA
PGTSPQPSLS ASTEPAVPTP TQTTATEKTT LWVTPSIRST AALTSQTGSS SGPVTVTPSA
PGTTTCQPRC QWTEWFDEDY PKSEQLGGDV ESYDKIRAAG GHLCQQPKDI ECQAESFPNW
TLAQVGQKVH CDVHFGLVCR NWEQEGVFKM CYNYRIRVLC CSDDHCRGRA TTPPPTTELE
TATTTTTQAL FSTPQPTSSP GLTRAPPAST TAVPTLSEGL TSPRYTSTLG TATTGGPTTP
AGSTEPTVPG VATSTLPTRS ALPGTTGSLG TWRPSQPPTL APTTMATSRA RPTGTASTAS
KEPLTTSLAP TLTSELSTSQ AETSTPRTET TMSPLTNTTT SQGTTRCQPK CEWTEWFDVD
FPTSGVAGGD METFENIRAA GGKMCWAPKS IECRAENYPE VSIDQVGQVL TCSLETGLTC
KNEDQTGRFN MCFNYNVRVL CCDDYSHCPS TPATSSTATP SSTPGTTWIL TKPTTTATTT
ASTGSTATPT STLRTAPPPK VLTTTATTPT VTSSKATPSS SPGTATALPA LRSTATTPTA
TSVTPIPSSS LGTTWTRLSQ TTTPTATMST ATPSSTPETA HTSTVLTATA TTTGATGSVA
TPSSTPGTAH TTKVPTTTTT GFTATPSSSP GTALTPPVWI STTTTPTTRG STVTPSSIPG
TTHTATVLTT TTTTVATGSM ATPSSSTQTS GTPPSLTTTA TTITATGSTT NPSSTPGTTP
IPPVLTTTAT TPAATSNTVT PSSALGTTHT PPVPNTMATT HGRSLPPSSP HTVRTAWTSA
TSGILGTTHI TEPSTVTSHT LAATTGTTQH STPALSSPHP SSRTTESPPS PGTTTPGHTT
ATSRTTATAT PSKTRTSTLL PSSPTSAPIT TVVTMGCEPQ CAWSEWLDYS YPMPGPSGGD
FDTYSNIRAA GGAVCEQPLG LECRAQAQPG VPLRELGQVV ECSLDFGLVC RNREQVGKFK
MCFNYEIRVF CCNYGHCPST PATSSTAMPS STPGTTWILT ELTTTATTTE STGSTATPSS
TPGTTWILTE PSTTATVTVP TGSTATASST QATAGTPHVS TTATTPTVTS SKATPFSSPG
TATALPALRS TATTPTATSF TAIPSSSLGT TWTRLSQTTT PTATMSTATP SSTPETVHTS
TVLTTTATTT GATGSVATPS STPGTAHTTK VLTTTTTGFT ATPSSSPGTA RTLPVWISTT
TTPTTRGSTV TPSSIPGTTH TPTVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI
TATGSTTNPS STPGTTPIPP VLTTTATTPA ATSSTVTPSS ALGTTHTPPV PNTTATTHGR
SLSPSSPHTV RTAWTSATSG TLGTTHITEP STGTSHTPAA TTGTTQHSTP ALSSPHPSSR
TTESPPSPGT TTPGHTRATS RTTATATPSK TRTSTLLPSS PTSAPITTVV TMGCEPQCAW
SEWLDYSYPM PGPSGGDFDT YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS
LDFGLVCRNR EQVGKFKMCF NYEIRVFCCN YGHCPSTPAT SSTATPSSTP GTTWILTEQT
TAATTTATTG STAIPSSTPG TAPPPKVLTS TATTPTATSS KATSSSSPRT ATTLPVLTST
ATKSTATSFT PIPSFTLGTT GTLPEQTTTP MATMSTIHPS STPETTHTST VLTTKATTTR
ATSSMSTPSS TPGTTWILTE LTTAATTTAA TGPTATPSST PGTTWILTEP STTATVTVPT
GSTATASSTR ATAGTLKVLT STATTPTVIS SRATPSSSPG TATALPALRS TATTPTATSV
TAIPSSSLGT AWTRLSQTTT PTATMSTATP SSTPETVHTS TVLTTTTTTT RATGSVATPS
STPGTAHTTK VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS STPGTTPIPP
VLTTTATTPA ATSSTVTPSS ALGTTHTPPV PNTTATTHGR SLPPSSPHTV RTAWTSATSG
ILGTTHITEP STVTSHTPAA TTSTTQHSTP ALSSPHPSSR TTESPPSPGT TTPGHTRGTS
RTTATATPSK TRTSTLLPSS PTSAPITTVV TTGCEPQCAW SEWLDYSYPM PGPSGGDFDT
YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF
NYEIRVFCCN YGHCPSTPAT SSTATPSSTP GTTWILTKLT TTATTTESTG STATPSSTPG
TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA TTPTVTSSKA TPFSSPGTAT
ALPALRSTAT TPTATSFTAI PSSSLGTTWT RLSQTTTPTA TMSTATPSST PETAHTSTVL
TTTATTTRAT GSVATPSSTP GTAHTTKVPT TTTTGFTVTP SSSPGTARTP PVWISTTTTP
TTSGSTVTPS SVPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL ITTATTITAT
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLS
PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG TTQHSTPALS SPHPSSRTTE
SPPSPGTTTP GHTTATSRTT ATATPSKTRT STLLPSSPTS APITTVVTTG CEPQCAWSEW
LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLGEL GQVVECSLDF
GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST AMPSSTPGTT WILTELTTTA
TTTASTGSTA TPSSTPGTAP PPKVLTSPAT TPTATSSKAT SSSSPRTATT LPVLTSTATK
STATSVTPIP SSTLGTTGTL PEQTTTPVAT MSTIHPSSTP ETTHTSTVLT TKATTTRATS
STSTPSSTPG TTWILTELTT AATTTAATGP TATPSSTPGT TWILTELTTT ATTTASTGST
ATPSSTPGTT WILTEPSTTA TVTVPTGSTA TASSTQATAG TPHVSTTATT PTVTSSKATP
SSSPGTATAL PALRSTATTP TATSFTAIPS SSLGTTWTRL SQTTTPTATM STATPSSTPE
TVHTSTVLTA TATTTGATGS VATPSSTPGT AHTTKVPTTT TTGFTATPSS SPGTALTPPV
WISTTTTPTT TTPTTSGSTV TPSSIPGTTH TARVLTTTTT TVATGSMATP SSSTQTSGTP
PSLTTTATTI TATGSTTNPS STPGTTPITP VLTSTATTPA ATSSKATSSS SPRTATTLPV
LTSTATKSTA TSFTPIPSST LWTTWTVPAQ TTTPMSTMST IHTSSTPETT HTSTVLTTTA
TMTRATNSTA TPSSTLGTTR ILTELTTTAT TTAATGSTAT LSSTPGTTWI LTEPSTIATV
MVPTGSTATA SSTLGTAHTP KVVTTMATMP TATASTVPSS STVGTTRTPA VLPSSLPTFS
VSTVSSSVLT TLRPTGFPSS HFSTPCFCRA FGQFFSPGEV IYNKTDRAGC HFYAVCNQHC
DIDRFQGACP TSPPPVSSAP LSSPSPAPGC DNAIPLRQVN ETWTLENCTV ARCVGDNRVV
LLDPKPVANV TCVNKHLPIK VSDPSQPCDF HYECECICSM WGGSHYSTFD GTSYTFRGNC
TYVLMREIHA RFGNLSLYLD NHYCTASATA AAARCPRALS IHYKSMDIVL TVTMVHGKEE
GLILFDQIPV SSGFSKNGVL VSVLGTTTMR VDIPALGVSV TFNGQVFQAR LPYSLFHNNT
EGQCGTCTNN QRDDCLQRDG TTAASCKDMA KTWLVPDSRK DGCWAPTGTP PTASPAAPVS
STPTPTPCPP QPLCDLMLSQ VFAECHNLVP PGPFFNACIS DHCRGRLEVP CQSLEAYAEL
CRARGVCSDW RGATGGLCDL TCPPTKVYKP CGPIQPATCN SRNQSPQLEG MAEGCFCPED
QILFNAHMGI CVQACPCVGP DGFPKFPGER WVSNCQSCVC DEGSVSVQCK PLPCDAQGQP
PPCNRPGFVT VTRPRAENPC CPETVCVCNT TTCPQSLPVC PPGQESICTQ EEGDCCPTFR
CRPQLCSYNG TFYGVGATFP GALPCHMCTC LSGDTQDPTV QCQEDACNNT TCPQGFEYKR
VAGQCCGECV QTACLTPDGQ PVQLNETWVN SHVDNCTVYL CEAEGGVHLL TPQPASCPDV
SSCRGSLRKT GCCYSCEEDS CQVRINTTIL WHQGCETEVN ITFCEGSCPG ASKYSAEAQA
MQHQCTCCQE RRVHEETVPL HCPNGSAILH TYTHVDECGC TPFCVPAPMA PPHTRGFPAQ
EATAV*
mutated AA sequence MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT RRVSFVPPVT
VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN YVFSEHCRAA YEDFNVQLRR
GLVGSRPVVT RVVIKAQGLV LEASNGSVLI NGQREELPYS RTGLLVEQSG DYIKVSIRLV
LTFLWNGEDS ALLELDPKYA NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP
TEQCPDPLPL PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ RAQLCEDHCV
DGCFCPPGRS CTVLDDITHS GCLPLGQCPC THGGRTYSPG TSFNTTCSSC TCSGGLWQCQ
DLPCPGTCSV QGGAHISTYD EKLYDLHGDC SYVLSKKCAD SSFTVLAELR KCGLTDNENC
LKAVTLSLDG GDTAIRVQAD GGVFLNSIYT QLPLSAANIT LFTPSSFFIV VQTGLGLQLL
VQLVPLMQVF VRLDPAHQGQ MCGLCGNFNQ NQADDFTALS GVVEATGAAF ANTWKAQAAC
ANARNSFEDP CSLSVENENY ARHWCSRLTD PNSAFSRCHS IINPKPFHSN CMFDTCNCER
SEDCLCAALS SYVHACAAKG VQLSDWRDGV CTKYMQNCPK SQRYAYVVDA CQPTCRGLSE
ADVTCSVSFV PVDGCTCPAG TFLNDAGACV PAQECPCYAH GTVLAPGEVV HDEGAVCSCT
GGKLSCLGAS LQKSTGCAAP MVYLDCSNSS AGTPGAECLR SCHTLDVGCF STHCVSGCVC
PPGLVSDGSG GCIAEEDCPC VHNEATYKPG ETIRVDCNTC TCRNRRWECS HRLCLGTCVA
YGDGHFITFD GDRYSFEGSC EYILAQDYCG DNTTHGTFRI VTENIPCGTT GTTCSKAIKL
FVESYELILQ EGTFKAVARG PGGDPPYKIR YMGIFLVIET HGMAVSWDRK TSVFIRLHQD
YKGRVCGLCG NFDDNAINDF ATRSRSVVGD ALEFGNSWKL SPSCPDALAP KDPCTANPFR
KSWAQKQCSI LHGPTFAACR SQVDSTKYYE ACVNDACACD SGGDCECFCT AVAAYAQACH
DAGLCVSWRT PDTCPLFCDF YNPHGGCEWH YQPCGAPCLK TCRNPSGHCL VDLPGLEGCY
PKCPPSQPFF NEDQMKCVAQ CGCYDKDGNY YDVGARVPTA ENCQSCNCTP SGIQCAHSLE
ACTCTYEDRT YSYQDVIYNT TDGLGACLIA ICGSNGTIIR KAVACPGTPA TTPFTFTTAW
VPHSTTSPAL PVSTVCVREV CRWSSWYNGH RPEPGLGGGD FETFENLRQR GYQVCPVLAD
IECRAAQLPD MPLEELGQQV DCDRMRGLMC ANSQQSPPLC HDYELRVLCC EYVPCGPSPA
PGTSPQPSLS ASTEPAVPTP TQTTATEKTT LWVTPSIRST AALTSQTGSS SGPVTVTPSA
PGTTTCQPRC QWTEWFDEDY PKSEQLGGDV ESYDKIRAAG GHLCQQPKDI ECQAESFPNW
TLAQVGQKVH CDVHFGLVCR NWEQEGVFKM CYNYRIRVLC CSDDHCRGRA TTPPPTTELE
TATTTTTQAL FSTPQPTSSP GLTRAPPAST TAVPTLSEGL TSPRYTSTLG TATTGGPTTP
AGSTEPTVPG VATSTLPTRS ALPGTTGSLG TWRPSQPPTL APTTMATSRA RPTGTASTAS
KEPLTTSLAP TLTSELSTSQ AETSTPRTET TMSPLTNTTT SQGTTRCQPK CEWTEWFDVD
FPTSGVAGGD METFENIRAA GGKMCWAPKS IECRAENYPE VSIDQVGQVL TCSLETGLTC
KNEDQTGRFN MCFNYNVRVL CCDDYSHCPS TPATSSTATP SSTPGTTWIL TKPTTTATTT
ASTGSTATPT STLRTAPPPK VLTTTATTPT VTSSKATPSS SPGTATALPA LRSTATTPTA
TSVTPIPSSS LGTTWTRLSQ TTTPTATMST ATPSSTPETA HTSTVLTATA TTTGATGSVA
TPSSTPGTAH TTKVPTTTTT GFTATPSSSP GTALTPPVWI STTTTPTTRG STVTPSSIPG
TTHTATVLTT TTTTVATGSM ATPSSSTQTS GTPPSLTTTA TTITATGSTT NPSSTPGTTP
IPPVLTTTAT TPAATSNTVT PSSALGTTHT PPVPNTMATT HGRSLPPSSP HTVRTAWTSA
TSGILGTTHI TEPSTVTSHT LAATTGTTQH STPALSSPHP SSRTTESPPS PGTTTPGHTT
ATSRTTATAT PSKTRTSTLL PSSPTSAPIT TVVTMGCEPQ CAWSEWLDYS YPMPGPSGGD
FDTYSNIRAA GGAVCEQPLG LECRAQAQPG VPLRELGQVV ECSLDFGLVC RNREQVGKFK
MCFNYEIRVF CCNYGHCPST PATSSTAMPS STPGTTWILT ELTTTATTTE STGSTATPSS
TPGTTWILTE PSTTATVTVP TGSTATASST QATAGTPHVS TTATTPTVTS SKATPFSSPG
TATALPALRS TATTPTATSF TAIPSSSLGT TWTRLSQTTT PTATMSTATP SSTPETVHTS
TVLTTTATTT GATGSVATPS STPGTAHTTK VLTTTTTGFT ATPSSSPGTA RTLPVWISTT
TTPTTRGSTV TPSSIPGTTH TPTVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI
TATGSTTNPS STPGTTPIPP VLTTTATTPA ATSSTVTPSS ALGTTHTPPV PNTTATTHGR
SLSPSSPHTV RTAWTSATSG TLGTTHITEP STGTSHTPAA TTGTTQHSTP ALSSPHPSSR
TTESPPSPGT TTPGHTRATS RTTATATPSK TRTSTLLPSS PTSAPITTVV TMGCEPQCAW
SEWLDYSYPM PGPSGGDFDT YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS
LDFGLVCRNR EQVGKFKMCF NYEIRVFCCN YGHCPSTPAT SSTATPSSTP GTTWILTEQT
TAATTTATTG STAIPSSTPG TAPPPKVLTS TATTPTATSS KATSSSSPRT ATTLPVLTST
ATKSTATSFT PIPSFTLGTT GTLPEQTTTP MATMSTIHPS STPETTHTST VLTTKATTTR
ATSSMSTPSS TPGTTWILTE LTTAATTTAA TGPTATPSST PGTTWILTEP STTATVTVPT
GSTATASSTR ATAGTLKVLT STATTPTVIS SRATPSSSPG TATALPALRS TATTPTATSV
TAIPSSSLGT AWTRLSQTTT PTATMSTATP SSTPETVHTS TVLTTTTTTT RATGSVATPS
STPGTAHTTK VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS STPGTTPIPP
VLTTTATTPA ATSSTVTPSS ALGTTHTPPV PNTTATTHGR SLPPSSPHTV RTAWTSATSG
ILGTTHITEP STVTSHTPAA TTGTTQHSTP ALSSPHPSSR TTESPPSPGT TTPGHTRGTS
RTTATATPSK TRTSTLLPSS PTSAPITTVV TTGCEPQCAW SEWLDYSYPM PGPSGGDFDT
YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF
NYEIRVFCCN YGHCPSTPAT SSTATPSSTP GTTWILTKLT TTATTTESTG STATPSSTPG
TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA TTPTVTSSKA TPFSSPGTAT
ALPALRSTAT TPTATSFTAI PSSSLGTTWT RLSQTTTPTA TMSTATPSST PETAHTSTVL
TTTATTTRAT GSVATPSSTP GTAHTTKVPT TTTTGFTVTP SSSPGTARTP PVWISTTTTP
TTSGSTVTPS SVPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL ITTATTITAT
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLS
PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG TTQHSTPALS SPHPSSRTTE
SPPSPGTTTP GHTTATSRTT ATATPSKTRT STLLPSSPTS APITTVVTTG CEPQCAWSEW
LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLGEL GQVVECSLDF
GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST AMPSSTPGTT WILTELTTTA
TTTASTGSTA TPSSTPGTAP PPKVLTSPAT TPTATSSKAT SSSSPRTATT LPVLTSTATK
STATSVTPIP SSTLGTTGTL PEQTTTPVAT MSTIHPSSTP ETTHTSTVLT TKATTTRATS
STSTPSSTPG TTWILTELTT AATTTAATGP TATPSSTPGT TWILTELTTT ATTTASTGST
ATPSSTPGTT WILTEPSTTA TVTVPTGSTA TASSTQATAG TPHVSTTATT PTVTSSKATP
SSSPGTATAL PALRSTATTP TATSFTAIPS SSLGTTWTRL SQTTTPTATM STATPSSTPE
TVHTSTVLTA TATTTGATGS VATPSSTPGT AHTTKVPTTT TTGFTATPSS SPGTALTPPV
WISTTTTPTT TTPTTSGSTV TPSSIPGTTH TARVLTTTTT TVATGSMATP SSSTQTSGTP
PSLTTTATTI TATGSTTNPS STPGTTPITP VLTSTATTPA ATSSKATSSS SPRTATTLPV
LTSTATKSTA TSFTPIPSST LWTTWTVPAQ TTTPMSTMST IHTSSTPETT HTSTVLTTTA
TMTRATNSTA TPSSTLGTTR ILTELTTTAT TTAATGSTAT LSSTPGTTWI LTEPSTIATV
MVPTGSTATA SSTLGTAHTP KVVTTMATMP TATASTVPSS STVGTTRTPA VLPSSLPTFS
VSTVSSSVLT TLRPTGFPSS HFSTPCFCRA FGQFFSPGEV IYNKTDRAGC HFYAVCNQHC
DIDRFQGACP TSPPPVSSAP LSSPSPAPGC DNAIPLRQVN ETWTLENCTV ARCVGDNRVV
LLDPKPVANV TCVNKHLPIK VSDPSQPCDF HYECECICSM WGGSHYSTFD GTSYTFRGNC
TYVLMREIHA RFGNLSLYLD NHYCTASATA AAARCPRALS IHYKSMDIVL TVTMVHGKEE
GLILFDQIPV SSGFSKNGVL VSVLGTTTMR VDIPALGVSV TFNGQVFQAR LPYSLFHNNT
EGQCGTCTNN QRDDCLQRDG TTAASCKDMA KTWLVPDSRK DGCWAPTGTP PTASPAAPVS
STPTPTPCPP QPLCDLMLSQ VFAECHNLVP PGPFFNACIS DHCRGRLEVP CQSLEAYAEL
CRARGVCSDW RGATGGLCDL TCPPTKVYKP CGPIQPATCN SRNQSPQLEG MAEGCFCPED
QILFNAHMGI CVQACPCVGP DGFPKFPGER WVSNCQSCVC DEGSVSVQCK PLPCDAQGQP
PPCNRPGFVT VTRPRAENPC CPETVCVCNT TTCPQSLPVC PPGQESICTQ EEGDCCPTFR
CRPQLCSYNG TFYGVGATFP GALPCHMCTC LSGDTQDPTV QCQEDACNNT TCPQGFEYKR
VAGQCCGECV QTACLTPDGQ PVQLNETWVN SHVDNCTVYL CEAEGGVHLL TPQPASCPDV
SSCRGSLRKT GCCYSCEEDS CQVRINTTIL WHQGCETEVN ITFCEGSCPG ASKYSAEAQA
MQHQCTCCQE RRVHEETVPL HCPNGSAILH TYTHVDECGC TPFCVPAPMA PPHTRGFPAQ
EATAV*
speed 0.64 s
All positions are in basepairs (bp) if not explicitly stated differently.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
back to results table

Problems